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1	Medical : basic science, clinical, translational research, medical education, and miscellaneous	ABS-2
ASSOCIATED RISK FACTORS OF RAISED D-DIMER IN COVID-19 PATIENTS WITH DIABETES MELLITUS Myrtha R (1), Lukas GA (2*), Ayusari AA (3), and Wijayanto MA (2) 1Department of Cardiovascular, Faculty of Medicine, Sebelas Maret University, Indonesia 2Clinical Clerkship, Faculty of Medicine, Sebelas Maret University, Indonesia 3Department of Nutrition, Faculty of Medicine, Sebelas Maret University, Indonesia *USER-4 Abstract Abnormal coagulation function has been linked to the advancement of COVID-19 and diabetes mellitus (DM). However, the association of elevated D-dimer in COVID-19 patients with DM is unclear. This study aims to determine risk factors of raised D-dimer in COVID-19 patients with DM at Sebelas Maret University Hospital. This retrospective study statistically analysed the risk factors of 87 COVID-19 patients with DM who were admitted to Sebelas Maret University Hospital from March 2020 to January 2021. Data were collected from patients^ medical records. Binary logistic regression was applied to determine the association between potential variables on D-dimer. Among 87 patients, 70 had elevated D-dimer, while 17 had normal D-dimer. Age, admission oxygen saturation, patient outcome, newly diagnosed diabetic patients, admission plasma glucose levels and C-reactive protein (CRP) were significantly associated with D-dimer (p = 0.017, 0.026, 0.001, 0.011, 0.036 and 0.009, respectively). However, increasing age (odds ratio [OR] 1.098 and 95% confidence interval [CI] 1.009 to 1.195- p = 0.030) was associated with an increased likelihood of D-dimer elevation, while newly diagnosed diabetic patients (OR 0.205, CI 0.052 to 0.806- p = 0.023) were associated with a reduced likelihood of D-dimer elevation in COVID-19 patients with DM. Older COVID-19 diabetic patients are prone to have higher levels of D-dimer. Therefore, they can be in a hypercoagulable state with a worse prognosis. Keywords: COVID-19, diabetes mellitus, D-dimer Share Link | Plain Format | Corresponding Author (Graciella Angelica Lukas)

2	Medical : basic science, clinical, translational research, medical education, and miscellaneous	ABS-5
Study Epidemioloy TB MDR and Complication in Brain and Spine Lina Handayani Rachmi Fauziah Rahayu University Sebelas Maret Surakarta, Indonesia Abstract The World Health Organization (WHO) estimates that each year there are 9 million new TB cases. Annually, TB kills approximately 1.8 million people, making it second only to HIV/AIDS as the leading cause of death from infectious diseases. Among those infected with M. tuberculosis, approximately 50 million are infected with drug-resistant strains. Worldwide, an estimated 5,000,000 cases of MDR-TB emerge each year (5.3% of all new and previously treated TB cases), resulting in 110,000 deaths. MDR-TB is tuberculosis due to organisms that show high-level resistance to both isoniazid and rifampicin, with or without resistance to other anti-TB drugs. The problem of multidrug-resistant tuberculosis has also been identified in patients with tuberculous in the central nervous system (CNS) including the brain and spine tuberculous. Multidrug-resistant CNS tuberculous is often associated with a poor prognosis. CNS tuberculosis is a devastating disease of the central nervous system. It primarily affects the meninges of the brain and spinal cord along with adjacent brain parenchyma. The thoracic spine is involved in 50% of spinal tuberculosis. Whereas the lumbar and cervical spine are each involved in 25% of cases. CNS tuberculosis can manifest in a variety of forms, including tuberculous meningitis, tuberculomas, tuberculous abscesses, and miliary tuberculosis. A meticulous cytologic analysis of cerebrospinal fluid, neuroimaging of the brain and spine, and an appropriate clinical setting are the key factors that help the diagnosis. Keywords: Keywords: CNS Tuberculosis, multidrug-resistant tuberculosis, brain and spine Share Link | Plain Format | Corresponding Author (Lina Handayani)

3	Medical : basic science, clinical, translational research, medical education, and miscellaneous	ABS-6
RELATIONSHIP OF PREGNANT MOTHERS BEHAVIOR WITH STUNTING EVENTS IN TODDLERS DURING THE COVID-19 PANDEMIC IN INDONESIA Naya Ernawati, Fitriana Kurniasari Solikhah, Erlina Suci Astuti Politeknik Kesehatan Kemenkes Malang Abstract RELATIONSHIP OF PREGNANT MOTHERS BEHAVIOR WITH STUNTING EVENTS IN TODDLERS DURING THE COVID-19 PANDEMIC IN INDONESIA Naya Ernawati, Fitriana Kurniasari Solikhah, Erlina Suci Astuti Nursing Department, Poltekkes Kemenkes Malang, Malang email: naia.erna@gmail.com Abstract: The Covid-19 pandemic causes the economic condition of the community to decline and causes an increase in poverty. One of the consequences of poverty is the increase in the incidence of stunting. Analyzing the behavior of pregnant mothers will be effective for the government, health workers, and the community to reduce stunting rates. This study aims to determine the relationship between pregnant mothers behavior and the incidence of stunting in toddlers. This study used a mixed methods research with a retrospective cohort approach. Qualitative data using FGDs were analyzed using Nvivo 12 with questionnaires and anthropometric measurements. The sampling method is purposive sampling with 77 respondents analysis used Spearman rank test. The results showed that the pregnant mothers behavior was significantly related to the incidence of stunting in toddlers. The FGDs informed about pregnant mothers behavior such as maternal visits for antenatal care (ANC), fulfillment of nutritional needs, and iron consumption as significant contributors to the incidence of stunting. Conclusion: Pregnant mothers behavior is very necessary for the prevention of stunting in children. Future research is expected to strengthen health behavior for pregnant women given by health workers as an effort to prevent stunting in toddlers. Keywords: Keywords: Covid-19, Pregnant mothers behavior, Stunting, Toddlers aged 12-59 months Share Link | Plain Format | Corresponding Author (Naya Ernawati Ernawati)

4	Medical : basic science, clinical, translational research, medical education, and miscellaneous	ABS-9
The Correlation between Neutrophil-to-Lymphocyte Ratio and Length of Stay in Pregnant Women with COVID-19 Ariva Syivaa (a*), Hafi Nurinasari (b), Nurhasan Agung Prabowo (b), Asih Anggraeni (b) a) Faculty of Medicine, Universitas Sebelas Maret Jalan Ir. Sutami 36, Kentingan, Jebres, Surakarta *arivasyivaa9[at]student.uns.ac.id b) Universitas Sebelas Maret Hospital, Ahmad Yani 200, Makamhaji, Kartasura, Sukoharjo, Central Java Abstract Introduction: Evidence suggests that pregnant women have a higher hospitalisation rate when infected with COVID19. It is necessary to identify the possible length of stay for COVID19 patients, which can predict when the hospital will reach capacity and prepare the required staff or equipment: the Neutrophil to Lymphocyte Ratio (NLR). This study aimed to determine the relationship between Neutrophil-to-Lymphocyte Ratio and length of hospital stay (LoS) in pregnant women with COVID19. Methods: This study is an analytic observational study with a cross-sectional design. Statistical test with unpaired T-test with p<0.05. Thirty-four subjects were obtained, with 16 research subjects in K1 (LoS < 7 day) and 18 in K2 (LoS >= 7 day). Results: The mean age of the subjects was 31.59 years, mostly in the 3rd trimester of pregnancy. The Unpaired T-test results showed no significant relationship between NLR values and LoS (p = 0.749) in patients with COVID19 pregnant women. Conclusion: There is no relationship between NLR and LoS in pregnant women with COVID-19. Keywords: COVID-19, SARS-CoV-2, Neutrophil Lymphocyte Ratio, Length of Hospital Stay Share Link | Plain Format | Corresponding Author (Ariva Syivaa)

5	Medical : basic science, clinical, translational research, medical education, and miscellaneous	ABS-10
Creatinine and Blood Urea Nitrogen levels in relation to Mortality rate of COVID-19 patients Gibraltar Kasyiful Haqi1,a, Berty Denny Hermawati2, Sigit Setyawan1 1) Faculty of Medicine, Universitas Sebelas Maret, Surakarta, Indonesia 2) Department of Internal Medicine, UNS Teaching Hospital, Faculty of Medicine, Universitas Sebelas Maret, Surakarta, Indonesia a) corresponding author: gibraltarkh[at]student.uns.ac.id Abstract Coronavirus disease 2019 (COVID-19) is a contagious, life-threatening infection caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The SARS-CoV-2 virus enters the human body by binding to the ACE2 (Angiotensin-Converting Enzyme 2) receptor. ACE2 is expressed in various human organs such as the heart, kidney, brain, and lungs. This is thought to be the cause of organ failure in many cases of COVID-19, especially in the kidney. The most frequent examination of kidney function is the examination of creatinine levels and blood urea nitrogen (BUN). Recent research suggests that creatinine and blood urea nitrogen (BUN) levels are more likely to rise during COVID-19 infection. Only a few studies, in several countries, have shown that there is a relationship between creatinine and BUN levels with an increased mortality rate in patients with COVID-19. Due to the lack of the research, this study aims to find out if there is a significant correlation between creatinine and BUN levels with the COVID-19 mortality rate. This study was done using an analytic observational method through a cross-sectional approach to 116 confirmed COVID-19 patients in Sebelas Maret University Hospital, Surakarta, Indonesia, as samples. From our analysis using the chi-square test, we have obtained a creatinine-mortality rate result of 0.020 < 0.050, (p-value = 7.844 > 5.991, contingency coefficient C = 0.252, Odds Ratio (OR) = 0.532), and a BUN-mortality rate result of 0.000 < 0.050, (p-value = 7.844 > 5.991, contingency coefficient C = 0.381, Odds Ratio (OR) = 0.183). Finally, it can be concluded that there is a significant relationship between creatinine and blood urea nitrogen (BUN) levels with the mortality rates of COVID-19 patients at Sebelas Maret University Hospital. Keywords: COVID-19, BUN, Creatinine, Kidney Share Link | Plain Format | Corresponding Author (Gibraltar Kasyiful Haqi)

6	Medical : basic science, clinical, translational research, medical education, and miscellaneous	ABS-11
Dementia Prevalence and Distribution in Central Java (Neuroscience) Dito Fadilla1 Rachmi Fauziah Rahayu2 1Radiology Resident, Sebelas Maret University Surakarta, Indonesia 2Staff of Radiology Sebelas Maret University Surakarta, Indonesia Abstract Impaired cognitive function is a global public health problem that occurs around the world associated with old age. It is characterized by various degenerative diseases such as Dementia and Alzheimer^s whose numbers are increasing every year. Dementia is not a specific disease but is rather a general term for the impaired ability to remember, think, or make decisions that interferes with doing everyday activities. Alzheimer^s disease is the most common type of dementia. Though dementia mostly affects older adults, it is not a part of normal aging. People with dementia have symptoms of cognitive decline that interfere with daily life-including disruptions in language, memory, attention, recognition, problem solving, and decision-making. The global burden of dementia has been estimated that 35,6 million people are living with dementia worldwide and projected to increase to 65,7 million by 2030 and 115.4 million by 2050. In Indonesia, the dementia prevalence increased twice every 5 years after passes 60 years old and reached to the sixth place of nine countries in Asia. Dementia study based on SurveyMETER that held on December 2015, the dementia prevalence in DIY and Central Java was 20.1%, which is more higher than global condition that under 10%. Keywords: Dementia, Alzheimer^s Disease, Prevalence Share Link | Plain Format | Corresponding Author (DITO FADILLA)

7	Medical : basic science, clinical, translational research, medical education, and miscellaneous	ABS-13
Effect of Chitosan Nanoparticles from Red Snapper Scales (Lutjanus Sp) on Pulp Repair (In Vivo Study)mit This Sample Abstract Noor Hafida Widyastuti1, Adi Prayitno2, Risya Cilmiaty3, and Brian Wasita4 Doctoral Program of Medical Science, Program of MedicalScience, Faculty of Medicine, Universitas Sebelas Maret Abstract Exposed pulp due to iatrogenic action can cause pulp inflammation. Reversible pulpitis is a mild to moderate inflammatory condition that can be treated with pulp capping treatment. Pulp capping treatment can support pulp repair by forming reparative dentin. The pulp caping material determines the success of the treatment. Calcium hydroxide (Ca(OH)2) is the gold standard material for the treatment but has many drawbacks. Chitosan has antibacterial and anti-inflammatory activity. Red snapper scales contain chitin which can be processed into chitosan nanoparticles. This study aims to determine the effect of chitosan nanoparticles (CN) from Red Snapper Scales (Lutjanus Sp) on pulp repair (identify from the expression of TGF-&#946-, the number of odontoblast like-cells, the formation of reparative dentin). This research laboratory is done in vivo using 24 samples of Sprague Dawley rats. The study uses four groups there are healthy rat groups, reversible pulpitis, reversible pulpitis applied the Ca(OH)2 and reversible pulpitis group applied CN. Observations of expression of TGF-&#946- using ELISA, odontoblast-like cells and dentine reparative formation using the histopathological examination. The results showed that one-way Anova Test for TGF-&#946- expression obtained p=0,049 (p<0.05). Kruskal Wallis test for odontoblast like-cell obtained p=0,006 (p<0,05) and for dentin reparative formation p=0,009 (p<0,05). This means that there is a significant difference between groups. Based on the results of the study, it can be concluded that red snapper scales chitosan nanoparticles enhance TGF-&#946- expression on of odontoblast-like cells and dentine reparative formation in the pulp repair process Keywords: chitosan nanoparticle, TGF-&#946-, Pulp repair, Dentin reparative Share Link | Plain Format | Corresponding Author (Noor Hafida Widyastuti)

8	Medical : basic science, clinical, translational research, medical education, and miscellaneous	ABS-14
Prospects of Melatonin as Adjuvant Therapy in Schizophrenic Patients: A Bibliometric Analysis Wahyuni1*, Satiawardana2, Herdaetha3, Kusuma 4 and Pramono5 1 Department of Psychiatry, Faculty of Medicine, Universitas Sebelas Maret, Indonesia 2Library, Universitas Sebelas Maret, Indonesia 3Department of Psychiatry, dr. Arif Zainudin Mental Hospital, Indonesia 4Department of Psychiatry, Faculty of Medicine, Universitas Sebelas Maret, Indonesia 5Department of Electrical Engineering, Faculty of Engineering, Universitas Sebelas Maret, Indonesia Abstract Schizophrenia is a severe mental disorder with a high recurrence rate. Schizophrenia sufferers experience persistent symptoms, interfering with their daily functions, which lead to decreased productivity. Various attempts have been made to improve clinical symptoms, one of them being providing additional therapies such as antioxidants, anti-inflammatory, and psychotherapy. As an adjuvant therapy, melatonin can play a role in attenuating pro-inflammatory cytokines and other inflammatory mediators and act as a free radical scavenger that protects from oxidative damage. This study was conducted to obtain an overview of the development of additional therapy research in schizophrenia patients and to see the prospects of melatonin being studied as an adjunct therapy. The data were taken from Scopus-indexed articles between 2003 and 2022. We analyzed these data bibliometrically using Vosviewer. We obtained 521 Scopus-indexed articles, in which VOSviewer visualization clustered them into 11 clusters relating to additional therapy for schizophrenia. Visualization results also revealed that studies on melatonin as adjuvant therapy for schizophrenia were still limited. In conclusion, the use of melatonin as adjuvant therapy for schizophrenic patients is prospective to be developed Keywords: schizophrenia, adjuvant therapy, melatonin, bibliometric analysis, VOSviewer, co-occurrence analysis Share Link | Plain Format | Corresponding Author (Siti Wahyuni)

9	Medical : basic science, clinical, translational research, medical education, and miscellaneous	ABS-15
ASSOCIATION OF LIPID PROFILES AND COGNITIVE FUNCTION DETERIORATION IN ISCHEMIC STROKE PATIENTS Diah Kurnia Mirawati, Budianto P, Prabaningtyas HRP, Subandi S, Danuaji R, Ristinawati I, Tedjo AA, Syah FK, Zakiah IZ, Putra SE, Hafizhan M Neurology Department, Faculty of Medicine, Universitas Sebelas Maret Abstract Vascular dementia, often caused by stroke, is the second most common type of dementia. Declining cognitive function after ischemic stroke could appear with varying degrees of severity and onset. Overlapping neurodegenerative and vascular damage are suspected to be a contributing factor to this variability. In this cross sectional study, we investigate correlation between lipid profile, a biomarker of vascular dysfunction, and cognitive function in ischemic stroke patients. There were 52 respondents (mean age 64.21), and Spearman correlation test found moderate positive correlation (r=0.658, p=0.04) between lipid profile and cognitive function deterioration. Ordinal regression analysis used to calculate odds ratios (OR) of cognitive function deterioration associated with lipid profile. The OR of cognitive function deterioration with the profile HDL, LDL, triglycerides, and total cholesterol were -1.54 (95% CI -0.98 - -3.46, p=0.002)- 1.78 (95% CI 1.27-2.46, p=0.000)- 2.48 (95% CI 1.39-4.92, p=0.04)- and 1.54 (95% CI 1.04-2.48, p=0.003) respectively. Keywords: ischemic stroke, cognitive function deterioration, lipid profile Share Link | Plain Format | Corresponding Author (Diah Kurnia Mirawati)

10	Medical : basic science, clinical, translational research, medical education, and miscellaneous	ABS-16
A Cost-effectiveness Analysis of Ferric Carboxymaltose in Patients with Heart Failure and Iron Deficiency: A Systematic Review Ratih Puspita Febrinasari (1), Qonita Fatikhia Syafira (2), Namira Putri Imani (2), Mega Astriningrum (2), Yusuf Ari Mashuri (2*) 1. Department of Pharmacology, Faculty of Medicine, Universitas Sebelas Maret, Indonesia 2. Faculty of Medicine, Universitas Sebelas Maret, Indonesia * yusufmashuri[at]staff.uns.ac.id Abstract Introduction: Iron deficiency is one of the heart failure comorbidities. As therapy of choice, ferric carboxymaltose can improve clinical symptoms and increase the quality of life in heart failure patients with iron deficiency. This study aims to evaluate and conclude the cost-effectiveness of ferric carboxymaltose in heart failure patients with iron deficiency. Methods: This was a systematic review of all articles collected from databases such as Pubmed, Scopus, Web of Science, EBSCO, ProQuest, Science Direct, and Global Health Databases which were published from 2012 to 2022. The population in this study were HFrEF patients with iron deficiency older than 18 years old who were treated with ferric carboxymaltose. A descriptive narrative approach using the CHEERS checklist was used to analyze the data. Results: Seven studies from 679 articles were included in the analysis. One article used the Markov model study design, five articles with model-based study, and one article used a cost-utility approach. Two articles used the payer^s perspective, an article about the healthcare provider^s perspective, and four articles used the healthcare national system^s perspective. Five articles have very good quality (70-85%), and two articles have high quality (>85%). From ten countries (Spain, UK, Sweden, Denmark, Finland, Norway, South Korea, Italy, USA, and Switzerland), South Korea has the highest ICERs at -18.254/QALY, with an incremental cost of -466, and the outcomes 0.021 QALY. Conclusions: Ferric carbooxymaltose is cost-effective for heart failure with iron deficiency treatment, which has an average ICER value of -7,814/QALY and a middle value of -6,678/QALY. Keywords: cost-effectiveness, ferric carboxymaltose, heart failure, iron deficiency, pharmacoeconomic Share Link | Plain Format | Corresponding Author (Ratih Puspita Febrinasari)

11	Medical : basic science, clinical, translational research, medical education, and miscellaneous	ABS-17
MEDICAL NUTRITIONAL THERAPY IN INGUINAL SQUAMOUS CELL CARCINOMA AND CARDIORENAL SYNDROME UNDERGOING HEMODIALYSIS : A CASE REPORT Kurnia Agustina Sitompul 1*, Diyah Eka Andayani 2 1 Klinik Panacea, Balikpapan 2 Departemen Ilmu Gizi, Fakultas Kedokteran Universitas Indonesia, Rumah Sakit Umum Pusat Nasional Dr. Cipto Mangunkusumo, Jakarta Abstract Malignancy can lead to kidney and heart disorder through number of mechanisms. Severe disturbance of renal function requires kidney replacement therapy such as hemodialysis. All this process induce protein energy wasting condition that reduce quality of life. A 51-year old male patient, diagnosed acute on chronic kidney disease on hemodialysis, obstructive nephropathy, inguinal squamous cell carcinoma, deep vein thrombosis, history of congestive heart failure fc III. Patient underwent nutritional therapy by giving energy and protein starting from 20 kcal/kgBW/day and 0.9 g/kgBW. The administration of protein is adjusted on dialysis status and urea level. Protein intake > 1 g/kgBW result in increasing the urea level of patient. Nutritional therapy is needed to support the quality of life improvement, reduce length of stay and prevent further malnutrition. Keywords: Carcinoma, Chronic Kidney Disease, Haemodialysis, Protein, Urea Share Link | Plain Format | Corresponding Author (Kurnia Agustina Sitompul)

12	Medical : basic science, clinical, translational research, medical education, and miscellaneous	ABS-18
Moringa Leaves (Moringa oleifera, Lam.) as a Potential Prophylaxis and Therapy of Steatosis and Liver Inflammation Winastari Yarhanim Triniputri, S.Ked- dr. Novan Adi Setyawan, Sp.PA- dr. Riza Novierta Pesik, M.Kes- Dra. Dyah Ratna Budiani, M.Si- Muhana Fawwazy Ilyas, S.Ked- Dr. Revi Gama Hatta Novika, SST., M.Kes Medical Doctor Profession Education, Sebelas Maret University Abstract Metabolic syndrome can manifest on hepatic steatosis and inflammation characterized by increased expression of TNF-&#945-. Moringa is reported to be one of those therapeutic agents for metabolic syndrome. This study aims to determine the effect of ethanolic extract of Moringa leaves on hepatic steatosis and TNF-&#945- expression in metabolic syndrome rats. This laboratory experimental research used 30 Rattus norvegicus as research subjects, divided into 5 groups: NC as the normal control group- MS as the metabolic syndrome group receiving a high-fat diet and STZ-NA injection- I1, I2, and I3 as the metabolic syndrome group receiving Moringa leaf extract at a dose of 150 mgKgBW-1, 250 mgKgBW-1, and 350 mgKgBW-1, respectively. The percentage of steatosis was calculated, analyzed with OneWay ANOVA test, followed by Tukey HSD post-hoc test. TNF-&#945- expression was calculated using the IDS score, analyzed with Kruskal Wallis test, followed by Mann-Whitney post hoc test. Steatosis and TNF-&#945- expression were also tested for correlation using Spearman^s test. This study showed a significant differences in hepatic steatosis between all groups except for NC and I3, as well as I2 and I3. There were also significant differences in hepatic TNF- &#945- expression between all groups except for NC and I3, MS and I1, as well as I1 and I2. The correlation coefficient of Moringa leaf extract to steatosis is -0.930, and to TNF-&#945- expression is -0.864. Inconclusion, ethanolic extract of Moringa leaves (Moringa oleifera, Lam.) very strongly reduces steatosis and TNF-&#945- expression in the liver of metabolic syndrome rats. Keywords: Moringa oleifera Leaf, Steatosis, Liver TNF-&#945- Share Link | Plain Format | Corresponding Author (Winastari Yarhanim Triniputri)

13	Medical : basic science, clinical, translational research, medical education, and miscellaneous	ABS-19
EFFECT OF N-ACETYL CYSTEIN ON SUPEROXIDE DISMUTASE LEVEL AND MUCOCILIAR TRANSPORT IN CHRONIC SUPPURATIVE OTITIS MEDIA Pratiwi DEWI1*, Nabila1, Primadewi NOVI1, Sudrajad HADI1 Department of Otorhinolaryngology Head and Neck Syrgery, Medical Faculty of Sebelas Maret University / Dr. Moewardi General Hospital, Surakarta, Indonesia Abstract Background: Chronic suppurative otitis media (CSOM) is inflammation of the middle ear characterized by perforation of the tympanic membrane and persistent discharge from the ear. Oxidative stress estimated play an important role in pathogenesis of CSOM. The primary enzyme in the defensive system against oxidative stress which known as Superoxide dismutase (SOD) is elicited to reduce the effect of superoxide radicals. Mucociliary transport of the eustachian tube is crucial for reducing middle ear inflammation, which can interfere with the mucosa^s healing process. N-Acetylsistein (NAC) is known as an antioxidant that is broadly effective despite its limited reactive oxygen species (ROS) activity. Additionally, it can reduce mucosal secretion in order to enhance mucociliary transport and prevent the development of biofilms. Objectives: To analyze the effect of NAC on SOD and mucociliary transport in CSOM patient. Methods: This research was conducted at the ENT Clinic Dr. Moewardi Hospital Surakarta, Indonesia from June - Augustus 2022 with the pretest-posttest control group design. Results: The mean level of SOD was increase significantly (24.37+-28.64 to 175.37+-114.60) (p=0.001) after intervention with NAC in the study group, compared to the control group (25.84+-33.45 to 24.62+-32.87) (p=0.327). There was also significant difference in mucociliary transport time in the study group compares to the control group (16.42+-7.02 vs 0.55+-0.84)(p=0.01) Conclusion: N-acetylcysteine exerts antioxidative effects via raising SOD levels and lowering mucociliary transit time in CSOM, which are associated with shorter healing times for the middle ear mucosa. Therefore the administration of NAC in patients with CSOM is highly recommended. Keywords: Chronic suppurative otitis media, superoxide dismutase, n-acetylsistein, mucociliary transport Share Link | Plain Format | Corresponding Author (Dewi Pratiwi)

14	Medical : basic science, clinical, translational research, medical education, and miscellaneous	ABS-20
THE RELATIONSHIP BETWEEN MIDDLE EAR IMPAIRMENT AND LANGUAGE DEVELOPMENT IN CHILDREN WITH DOWN SYNDROME Sudrajad HADI1*, Setiamika MADE1, Hendradewi SARWASTUTI1, Primadewi NOVI1, Wijaya Kandhi PUTU1, Pratiwi DEWI1, Permatasari DEFITARIA1, Giri Moelyo ANNANG2 Otorhinolaryngology Department, Sebelas Maret University Surakarta, Indonesia Pediatric Department, Sebelas Maret University Surakarta, Indonesia Abstract Background: Down syndrome (DS) is a trisomy disorder of chromosome 21. Hearing impairment in DS are related to anatomical alterations and general cognitive delays. Otitis media with effusion is one of the most common ear problems in DS. Anatomical abnormalities and incidence of otitis media may also influence the development of their leanguage. People with DS who have intellectual disabilities remain vulnerable to these complications and are at risk for language learning deficits. Objectives: To analyze the relationship between middle ear function and its problem with language development in children with DS. Methods: We measured the develpoment screening, tympanometric and otoaccoustic emissions (OAE) in 17 children with DS. The study was conducted between March-July 2022 at Pediatric and ENT clinic, Dr. Moewardi General Hospital Surakarta, Indonesia. Results: The mean age of subjects was 35.41 +- 18.78 months ranging from 12-73 months and ratio male and female 8 : 9. Development delay were found in all subjects based on Denver II, 6 (35.3%) were late and 11 (65.7) were very late . Mostly subjects had type B for tympanometric in both ears (41.17%) with otoaccoustic emissions result were dominated with refer result in both ears(58.3%). Chi Square Test between Tympanometry and Languange Development was found significant (p = 0.011). Conclusion: There is relationship between middle ear impairment and language development in children with down syndrome Keywords: Down syndrome, otitis media with effusion, language development, middle ear Share Link | Plain Format | Corresponding Author (Hadi Sudrajad)

15	Medical : basic science, clinical, translational research, medical education, and miscellaneous	ABS-24
The Immunomodulator Effective Dose of Nanosilver Biosynthetic based on Immunoglobulin G Level of Mice that Induced by Vaccine Compared with Herbal Immunostimulant Dian Eka Ermawati,Putri Indah Nuraini,Niki Putri Anjani,Adi Yugatama Universitas Sebelas Maret, Surakarta,Indonesia Abstract Immunization is an effort to increase a person^s immunity against a disease actively. The process of the formation of antibodies by the body after immunization requires complementary treatment for immunostimulators. Silver in the medical field developed as a therapeutic agent. When in the form of nanoparticles, it can reduce toxicity and act as an immune catalyst. Inulin acts as a bioreductant to synthesize silver because it is more environmentally friendly than physical and chemical methods. Nanosilver biosynthetic (AgNPs) from inulin must be verified as an immunomodulatory agent. This study aims to determine the effective dose of nanosilver based on Immunoglobulin G of Balb/c mice induced by the measles vaccine compared to herbal immunostimulants and their stability in 21 days. The research method was experimental in the laboratory. AgNPs biosynthesis process using inulin gembili as a bioreductant, then characterize using spectrophotometer UV-VIS and PSA, animal conditioning, treatment of an animal, ELISA test, and stability test of nanosilver. The data were processed using SPSS 21 and analyzed statistically using One Way ANOVA and Wilcoxon test. The results of the ELISA readings showed an increase in the Optical Density value of the nanosilver sample at a dose of 4 mg/kg.BW was higher than the other treatments but not significantly different from the herbal stimulant control. There is an effect of storage time on the stability of nanosilver during a storage period of 21 days at a temperature of 4 degree celcius on the maximum lambda shift. However, it is still in the nanoparticle size range. In addition, there is a change in the color of the solution from light brown to dark brown, which indicates that a nanosilver formation process has continued. Keywords: Immunomodulator, Inulin Gembili, Nanosilver, ELISA, Biosynthesis Share Link | Plain Format | Corresponding Author (Dian Eka Ermawati)

16	Medical : basic science, clinical, translational research, medical education, and miscellaneous	ABS-25
PROPOLIC EFFECT OF MOUNT LAWU ON EXPRESSION VASCULAR ENDOTHELIAL GROWTH FACTOR IN ACUTE RINOSINUSITIS MODEL MOUSE INDUCED BY ESCHERICHIA COLI Viquisa Berliana Putri AZIZA1*, Sabdo Nugroho WINULANG1, Hendradewi SARWASTUTI1, Sudrajad HADI1 1 Department of Otorhinolaryngology Head and Neck Surgery, Dr.Moewardi General Hospital Surakarta, Indonesia Abstract Background: Rhinosinusitis is an inflammatory disease of the nasal mucosa and paranasal sinuses. Bacterial rhinosinusitis caused by E.coli can increase the Vascular Endothelial Growth Factor (VEGF). Propolis can be considered an alternative therapy for rhinosinusitis. Objective: To determine the propolis effect on the expression of VEGF in acute rhinosinusitis model mouse induced by Escherichia coli. Methods: An Experimental study with post-test only control group design. The sample was 40 male white mouse SDF Sprague-Dawley which were divided into five groups, P1 group (control), P2 group (acute rhinosinusitis mouse model), P3 group (acute rhinosinusitis mouse model + amoxicillin 200 mg/kgBW), group P4 (mouse model acute rhinosinusitis + propolis 100 mg/kgBW) and group P5 (mouse model acute rhinosinusitis + propolis 200 mg BW). They were induced with right and left intranasal E. coli and 0.1 ml intraperitoneal each with a concentration of 3x109 colony forming units (CFU) ml for 28 days. On days 29 to 42, groups P3, P4, and P5 were treated with amoxicillin and propolis. On day 43 the subjects were turned off, followed by VEGF expression measurement. Result: Data analysis using Kruskal-Wallis test showed insignificant results (p=0,248). The VEGF expression at the beginning was high in P1, but in P2, P3 and P4 didn^t decrease VEGF expression, while P5 reduced VEGF expression but it was not significant. Conclusion: There was no effect of Mount Lawu propolis extract on VEGF expression in acute rhinosinusitis model mouse induced by Escherichia coli. Keywords: Propolic of mount lawu, echerichia coli, VEGF, acute rhinosinusitis Share Link | Plain Format | Corresponding Author (Aziza Viquisa Berliana Putri)

17	Medical : basic science, clinical, translational research, medical education, and miscellaneous	ABS-26
LUTEINIZING AND FOLLICLE STIMULATING HORMONE LEVEL IN FEMALE RATS POLYCYSTIC OVARIUM SYNDROME MODEL DUE TO KEBAR GRASS EXTRACT (Biophytum petersianum Klotszch) Putri N.R. 1 *, Hidayat S.T. 2 , Widyawati M.N. 3 , Suwondo A.4 , Sudirman 5 , Ramadhian A.A.N. 3 1 Midwifery Program, Faculty of Medical, Sebelas Maret University, Indonesia novirahardjo[at]staff.uns.ac.id 2 Medical Staff Group of Obstetric Gynecology Department, Dr. Kariadi Hospital, Semarang, Indonesia 3 Postgraduate Program, Poltekkes Kemenkes Semarang, Indonesia 4 Health and Work Safety Department, Faculty of Public Health, Diponegoro University, Semarang, Indonesia 5 Nursing Department, Poltekkes Ministry of Health Semarang - Indonesia Abstract ABSTRACT Polycystic Ovary Syndrome (PCOS) has become a global problem in infertility. Manifestations of PCOS are disorders of the folliculogenesis process due to an imbalance in the hypothalamic, pituitary and ovarian cycles which is the increase of LH:FSH levels that reach 3:1 at the beginning of the fertilization period. Medical therapy for infertility is ovulation induction, but there is a side effect that is ovarian hyperstimulation syndrome. Kebar grass (Biophytum petersianum Klotzsch) is an empirical herb used as fertilizer in Indonesia. The aim of the study was to determine the effect of Kebar grass extract on LH and FSH levels in PCOS model test animals. The research method is a true experiment with a post test only design with a control group design. The research sample consisted of 5 groups, namely KN, KP (PCOS), D1, D2, and D3 (dose of 31.5- 63 and 94.5 mg/kgbw). The result of the study was tested with a non-parametric test of Kruskall Wallis because the research data unnormally distributed. Kebar grass extract can reduce the decrease in LH levels and help increase the body^s FSH with values of 0.007 and 0.013 . The glycoprotein content in kebar grass which has the same atomic weight as PMSG is thought to be one of the main factors. PMSG is a complex glycoprotein that has a high function of FSH and low LH activity, so that the serum hormone can be used to increase ovulation by stimulating the growth of follicles in the ovaries. Keywords: Keywords: polycystic ovary syndrome, Luteinizing Hormone, Follicle Stimulating Hormone (FSH), Kebar Grass Share Link | Plain Format | Corresponding Author (Noviyati Rahardjo Putri)

18	Medical : basic science, clinical, translational research, medical education, and miscellaneous	ABS-27
Medical Nutritional Therapy In Malnourish Chronic Kidney Disease Patients Who Undergo Hemodialysis (Approaching To Mid Upper Arm Muscle Circumference) Muningtya Philiyanisa Alam (a), Diyah Eka Andayani (b), Lady Dhita Alfara (c) a) Rumah Sakit Umum Daerah Menggala, Indonesia b) Departemen Ilmu Gizi, Fakultas Kedokteran Universitas Indonesia, Rumah Sakit Cipto Mangunkusumo, Indonesia c) Department Ilmu Gizi, Rumah Sakit Sumber Waras, Indonesia Abstract Chronic kidney disease has become a global epidemic disease and the prevalence is increasing in Indonesia. Hemodialysis (HD) is the most common treatment for end stage renal disease (ESRD) patients. Patients who undergo HD routinely are vulnerable to increase protein energy wasting (PEW) so nutritional status must be monitored closely. Mid upper arm muscle circumference (MUAMC) can be use to show the total body protein and muscle mass. Medical nutritional therapy is needed to prevent patients from PEW and improve the quality of life. Four patients age range 32-61 years and same sex ratio, diagnosed with ESRD undergoing HD. Based on The American Society for Parenteral and Enteral Nutrition^s criteria all patients were malnutrition. Two patients experienced PEW and the other had risk of PEW. Medical nutritional therapy is given according to clinical condition of each patient with target protein from 1.1-1.4 g/kgBW/day. Energy and protein intake in two patients was more than 35 kcal/kgBW/day and 1.2 kcal/kgBW/day at first assessment. Unfortunately the others patient intake were low at the first assessment but incresed at the end of monitoring. All patients had low MUAMC scores which indicate muscle depletion. Two patients had increased MUAMC at the end of monitoring. Keywords: Chronic kidney disease, hemodialysis, medical nutritional therapy, upper arm muscle circumference, protein energy wasting. Share Link | Plain Format | Corresponding Author (Muningtya Philiyanisa Alam)

19	Medical : basic science, clinical, translational research, medical education, and miscellaneous	ABS-28
Medical Nutrition Therapy as Influencing Factor on Nutritional Status and Functional Capacity Improvement of Tuberculous Meningitis Patient: Case Report Dimas Erlangga Luftimas (1,2,3), Victor Tambunan (1), Diyah Eka Andayani (1) 1) Program Pendidikan Dokter Spesialis-1 Ilmu Gizi Klinik, FKUI-RSCM, Jakarta, Indonesia 2) Public Health Department, Faculty of Medicine Universitas Padjadjaran, Bandung, West Java, Indonesia 3) Nutrition Working Group, SKIPNAKES Study Centre, Faculty of Medicine Universitas Padjadjaran, Bandung, West Java, Indonesia Abstract Tuberculous Meningitis (TBM) has been the most severe manifestation of Tuberculosis infection attacking the central nervous system (CNS) and causes risk of malnutrition in patients due to decreasing ability of eating and loss of appetite. We focused on the nutritional aspect of TBM patient and its significance in patient health outcome. We describe a 35-years-old Asian male who was diagnosed with Tuberculous meningitis and had been hospitalized in neurology ward Cipto Mangunkusumo Hospital Jakarta. The patient had a headache, dizziness and seizure. After being diagnosed by TBM, the patient was then consulted to the Clinical Nutrition Department due to malnutrition appearance. The patient was observed, given high protein, and being monitored for BCAA intake. Nutritional status based on anthropometric indices did not seem to change during observation, but there were improvements in other nutritional outcome parameters, such as Total Lymphocyte Count, and functional capacity. Keywords: Tuberculous meningitis, medical nutrition therapy, Protein, BCAA, functional capacity Share Link | Plain Format | Corresponding Author (Dimas Erlangga Luftimas)

20	Medical : basic science, clinical, translational research, medical education, and miscellaneous	ABS-30
Solanum betaceum Extract Effect Malondialdehyde (MDA), Testosterone, and Sertoli cell on Lead Acetate Induced Mice (Mus Musculus) Nurul Jannatul Wahidah1,, Abadiyah Zakiyah2 , A.A Cyntia Riris2, Rima Wirenviona2, and Nurul Fatimah Susanti2, Revi Gama Hatta Novika1,Reny I^tishom3*, Siti Khaerunnisa4 1 Department of Midwifery, Faculty of Medicine Universitas Sebelas Maret, Surakarta, Indonesia 2 Master of Reproductive Health, Faculty of Medicine Universitas Airlangga, Surabaya, Indonesia 3 Department of Medical Biology, Faculty of Medicine Universitas Airlangga, Surabaya, Indonesia 4 Department of Medical Biochemistry, Faculty of Medicine Universitas Airlangga, Surabaya, Indonesia Abstract Please Just Try to Submit This Sample Abstract You Can Edit It Again Later This study aims to analyze whether the solanum betaceum extract effect malondialdehyde (MDA), testosterone, and Sertoli cell on lead acetate induced mice (Mus musculus). This study was a true experimental with a randomized posttest-only control group design using 40 male mice, 12-16 weeks age, 25-30 grams. Mice were acclimated then randomly divided into five groups, K- (negative control group, given aqua dest orally for 35 days), K+ (positive control group, given Aquadest and 75 mg/kg BW lead acetate orally for 35days), P1 (given 100 mg/kg BW Solanum betaceum extract orally for 35days and 75 mg/kg BW lead acetate), P2 (given 200 mg/kg BW Solanum betaceum extract orally for 35 days and 75 mg/kg BW lead acetate), P3 (given 400 mg/kg BW Solanum betaceum extract orally for 35 days and 75 mg/kg BW lead acetate). On day 36, mice were sacrificed, the testicular tissues were taken to evaluate the MDA level through ELISA test and their number of Sertoli cells through histological study. At the same time, 3ml of blood were taken from mice^s hearts to be analyzed for the testosterone level by ELISA test. Supplementation of Solanum betaceum to lead acetate induced mice decreases the MDA mean level, decreases testosterone level, and repair the Sertoli cell. Keywords: solanum betaceum, malondialdehyde, testosterone, Sertoli cell, lead acetate, and male infertility. Share Link | Plain Format | Corresponding Author (Nurul jannatul Wahidah)

21	Medical : basic science, clinical, translational research, medical education, and miscellaneous	ABS-31
INTERPROFESSIONAL RELATION MODELS IN TYPE 2 DIABETES MELLITUS: A SYSTEMATIC REVIEW^ Siti Marufah, Satibi, Nanang Munif Yasin, Susi Ari Kristina 1Doctoral Program, Faculty of Pharmacy, Universitas Gadjah Mada, Yogyakarta, 55281, Indonesia 2Department of Pharmacology, Faculty of Medicine, Universitas Sebelas Maret,Surakarta, 57126, Indonesia. 3Department of Pharmaceutics, Faculty of Pharmacy, Universitas Gadjah Mada, Yogyakarta, 55281, Indonesia Abstract Context: Diabetes Mellitus is one of the biggest non-communicable disease problems in 2021, and 90% of diabetes cases worldwide are type 2 diabetes mellitus. This chronic disease requires continuous monitoring by the Interprofessional relation team to prevent the progression of more severe complications and improve the quality of life. Objectives: To determine the models of interprofessional relations with the patient with type 2 diabetes mellitus in the community and hospital. Methods: A systematic literature search was conducted in three online databases (Google Scholar, Science Direct, and Scopus). From 22690 returned studies, 12 articles met the inclusion criteria. The quality of the paper was assessed using the Johns Hopkins evidence-based practice tools. A PRISMA flow chart documented the search, exclusion, and inclusion criteria study. Results: Most models used are a combination of training, daily huddles, collaborative care plans, team visits, patient phone call follow-up, medication reconciliations, education, student-led group diabetic visit guidelines, scientific meeting, and care network. Improvements were reported in HbA1c, blood pressure control, body mass index, low-density lipoprotein cholesterol, total cholesterol, seamless collaboration, security, time-saving, and automation. Conclusions: Interprofessional relations with one or a combination positively affect clinical and non-clinical parameters. Keywords: Multidisciplinary, Diabetes Mellitus type 2, Hospital, Community Share Link | Plain Format | Corresponding Author (Siti Marufah)

22	Medical : basic science, clinical, translational research, medical education, and miscellaneous	ABS-32
Neutrophil to Lymphocyte Ratio is Associated with Mid Term BPV in Hypertensive COVID-19 Patients Widi VSN (a*), Myrtha R (a, b), Hananto AZA (a, c), Ardyanto TD (a, d) and Maulidya T (a) a) Faculty of Medicine, Sebelas Maret University, Indonesia b) Department of Cardiology and Vascular Medicine, Sebelas Maret University Hospital, Indonesia c) Department of Anesthesiology and Intensive Therapy, Sebelas Maret University Hospital, Indonesia d) Department of Clinical Pathology, Sebelas Maret University Hospital, Indonesia Abstract Neutrophil-to-lymphocyte (NLR) is an inexpensive and feasible inflammatory marker. Inflammation has a key role in pathogenesis and progression of COVID-19 with hypertension. Blood pressure control in hypertension is influenced by blood pressure variability. A total of 192 COVID-19 patients with hypertension who were administered to Sebelas Maret University Hospital in June 2020 to February 2022 were included in this observational analytical study with a cross-sectional approach. Data were analyzed using Spearman or Pearson correlation analysis. Comparative analysis of independent T-test or Mann Whitney were used on numerical variables and Chi-Square test on categorical variables. There is a positive (unidirectional) and significant correlation (r = 0,223, p= 0,002) between the NLR dan blood pressure variability in COVID-19 patients with hypertension at Sebelas Maret University Hospital. There was a significant difference in the variables of admission oxygen saturation <93% (p<0.001) and mortality (p<0.001) which were found higher in patients with high NLR levels (>5.8) than normal NLR levels (<5.8). This study showed that admission NLR is weakly and positively correlated with blood pressure variability in COVID-19 patients with hypertension at Sebelas Maret University Hospital. An increase of admission NLR above the upper normal limit, can elevate the blood pressure variability, therefore it needs to be considered. Keywords: COVID-19- hypertension- NLR- blood pressure variability Share Link | Plain Format | Corresponding Author (Vina Sari Nugrahaning Widi)

23	Medical : basic science, clinical, translational research, medical education, and miscellaneous	ABS-33
Association of Mid Term Blood Pressure Variability with In-Hospital Mortality in Hypertensive COVID-19 Patients Maulidya T (a*), Myrtha R (a, b), Hananto AZA (a,c), Prabaningtyas HR (a,d), Widi VSN (a) a) Faculty of Medicine, Sebelas Maret University, Indonesia b) Department of Cardiology and Vascular Medicine, Sebelas Maret University Hospital, Indonesia c) Department of Anesthesiology and Intensive Therapy, Sebelas Maret University Hospital, Indonesia d) Department of Neurology, Sebelas Maret University Hospital, Indonesia Abstract Blood pressure variability is a biomarker that affects the clinical outcome of COVID-19 patients. COVID-19 patients with hypertension have a higher risk of death than patients without comorbidities. Blood pressure control in hypertension is influenced by blood pressure variability. This study aims to evaluate the relationship between blood pressure variability and in-hospital mortality in COVID-19 patients with hypertension. This study was an observational analytical study with a cross-sectional approach. This study analyzed 191 COVID-19 patients with hypertension who were administered to Sebelas Maret University Hospital in June 2020 to February 2022. Data were analyzed using logistic regression multivariate analysis and comparative analysis of independent T-test or Mann Whitney on numerical variables and Chi-Square test on categorical variables. p<0,05 is considered significant. There was no significant relationship between blood pressure variability and in-hospital mortality in COVID-19 patients with hypertension from the multivariate analysis (SD SBP (p=0,620), SD DBP (p=0,940), CV SBP (p=0,868), CV DBP (p=0,980)). Meanwhile, there was a significant relationship between mean SBP (p=0,014), age (p=0,018) and admission oxygen saturation (p<0,001) and in-hospital mortality. There is no significant relationship between blood pressure variability and in-hospital mortality of COVID-19 patients with hypertension. Keywords: Blood pressure variability, in-hospital mortality, COVID-19, hypertension Share Link | Plain Format | Corresponding Author (Tamara Maulidya)

24	Medical : basic science, clinical, translational research, medical education, and miscellaneous	ABS-35
INDUCTION OF FRESH CHOCOLATE CYST SLURRY INTO ENDOMETRIOSIS MICE MODEL Ivanna Beru Brahmana (a,b*) - Soetrisno(b)- Mulyoto Pangestu (c) -Rita Cempaka (d)- Ika Puspitasari (e) a. Obstetrics and Gynecology Departement, Faculty of Medicine and Health Sciences, Universitas Muhammadiyah Yogyakarta, Bantul, Indonesia, 55183 ivanna.beru.brahmana[at]gmail.com* b. Doctoral Program of Medical Science, Universitas Sebelas Maret, Surakarta, Indonesia, 57126 c. Education Program in Reproduction and Development, Dept. Obstetrics and Gynaecology, Monash University, Australiad. d. Departement of Pathology Anatomy, Faculty of Medicine, Universitas Gadjah Mada, Yogyakarta, Indonesia, 55281 e. Faculty of Pharmacy / Academic Hospital, Universitas Gadjah Mada, Yogyakarta, Indonesia, 55281 Abstract Background: The Covid-19 pandemic has prevented laparoscopy or laparostomy surgery, except in emergency. The endometrial lesions from laparoscopy or laparotomy to induce endometriosis-associated mice is not available. Chocolate cyst is one type of endometriosis in addition to the appearance of endometrial lesions. The limitations of obtaining these samples led to the idea of trying to induce fresh chocolate cyst pulp to become a model of endometriosis mice. Chocolate cyst slurry can be obtained through cyst puncture, no need to perform laparoscopy or laparotomy. Objective: to prove that induced mice with fresh chocolate cyst pulp samples succeeded in becoming endometriosis models of mice. Methods: Fresh chocolate cyst slurry was injected as much as 5.10-3 ml.g-1 of mice weight intraperitoneally on day zero. Mice of Mus musculus strain Balb/c were injected with cyclosporine 1.4.10-2 mg.g-1 of weight of mice intraperitoneally dayly for 14 days. On the 1st and 5th day the mice were injected with estradiol 2.6.10-4 ml.g-1 of the weight of the mice intramuscularly. Induction research on endometriosis model mice was conducted at the Pharmacology Laboratory of the Gadjah Mada University, Yogyakarta, Indonesia. On the 15th day the mice were necropsied for histopathological examination at the Anatomical Pathology Laboratory, Gadjah Mada University, Yogyakarta, Indonesia with Hematoxylin-Eosin (HE) staining. Results and conclusions: A total of 6 mice that were induced with fresh chocolate cyst pulp histopathologically showed signs of endometriosis. All of them were 100% successful in becoming endometriosis model mice, as a novelty in endometriosis studies using experimental animals. Keywords: fresh chocolate cyst pulp-endometriosis- endometriosis model mice- anatomical pathology Share Link | Plain Format | Corresponding Author (Ivanna Beru Brahmana)

25	Medical : basic science, clinical, translational research, medical education, and miscellaneous	ABS-36
THERAPEUTIC ACUPUNCTURE AND METHYLPREDNISOLONE EFFECTS TO CORTISOL LEVEL IN MICE WITH LUPUS NEPHRITIS MODEL Suparyanti, E.,L., Purwanto, B., Wasita, B., and Handayani, S. Sebelas Maret University Abstract Systemic Lupus Erythematosus (SLE) is an autoimmune disorder characterized by multiorgan involvement and various autoantibody with the target of cell components. One of the clinical manifestations of SLE is lupus nephritis. Acupuncture is one of the therapeutic methods that has a philosophy of self-healing potential, the ability of the body to heal itself. This study aims to understand the therapeutic effects of acupuncture points of Mingmen (GV4) and Zusanli (ST36) and methylprednisolone in mice with lupus nephritis model comparing cortisol level. This study is an experimental study on mice (Mus musculus) modeled with lupus nephritis using post-test only on control group design. The subjects were assigned into four groups, each with seven mice, consisting of control group (CN), negative control group given pristane (C(-)), first test group given pristane and methylprednisolone (P1), and second test group given pristane and acupuncture in Mingmen and Zusanli points. Significant p < 0,05. Result of this study found that there was a statistically significant difference between groups as demonstrated by one-way ANOVA test (F=11.710, p-value of 0.000). A Tukey post hoc test showed that the mice given pristane (C(-)) were found to have higher cortisol than P1 group (p-value of 0,000), P2 group (p-value of 0,025), and the control group (CN group) (p-value of 0,000). There was no significant difference found in control group (CN) with P1 group (p-value of 0,888), control group (CN) with P2 group (0,112), and P1 and P2 group (p-value of 0,374). Keywords: acupuncture, mingmen point, and zusanli point, methylprednisolone, lupus nephritis Share Link | Plain Format | Corresponding Author (Endang Listyaningsih Suparyanti)

26	Medical : basic science, clinical, translational research, medical education, and miscellaneous	ABS-37
Spirituality and Medical Education : Bibliometric Analysis of the Current State of the arts and Perspective Muhammad Fa^iz Rahmadany, Nanang Wiyono, Siti Munawaroh, Yunia Hastami Anatomy, Faculty of Medicine, Universitas Sebelas Maret, Surakarta Abstract To be able to understand the current research on spirituality and medical education, this study evaluates relevant themes related to spirituality and medical education through bibliometric analysis with the keyword ^spirituality and medical education^ as input. In this study using the Scopus database because it is considered ideal in bibliometric analysis. VOSviewer software is adopted as a bibliometric analysis tool to visualize authors^ networks, countries, journals, and keywords. The analysis conducted on August 15, 2022 found a total of 763 documents in the period from 1986 to 2022. The results showed that in the last 36 years, the number of publications of articles on spirituality and medical education has grown significantly. The USA is the country with the most article publications in the world with lead authors, and research institutes involved. Harvard Medical School became a prominent journal with regular publications. The bibliometric analysis presented provides relevant information related to the theme studied, namely spirituality and medical education. Keywords: Bibliometric- Spirituality- Medical Education- VOSviewer- Scopus Share Link | Plain Format | Corresponding Author (Faiz Rahmadany)

27	Medical : basic science, clinical, translational research, medical education, and miscellaneous	ABS-39
Efficacy of Intravenous Dexmedetomidine Versus Lidocaine on Postoperative Gynecological Surgery: Systematic Review and Meta-Analysis Aiman Hilmi Asaduddin(a*), Mentari Maratus Sholihah(b), Taufik Ridwan Hadi Kusuma(c), Azkia Rachmah(a) a) Medical Professional Education, Faculty of Medicine, Universitas Sebelas Maret, Surakarta, Indonesia *aimanhilmi02[at]student.uns.ac.id b) Medical Doctor, Internship, RSUP Dr Sitanala, Tangerang, Banten, Indonesia c) Medical Doctor, Internship, RSPAU dr. S. Hardjolukito, Yogyakarta, Special Region of Yogyakarta, Indonesia Abstract Background: Dexmedetomidine and lidocaine are two postoperative therapy regimens commonly used in gynecological surgery. Many studies suggest that these two regimens are promising agents for managing the transition from acute to chronic postoperative pain that occurs frequently during the rehabilitation of gynecological patients. Furthermore, the administration of these two regimens improves the procedure and quality of gynecological surgery recovery. Objective: We conducted a comprehensive evaluation of systematic review and meta-analysis to assess the efficacy of intravenous dexmedetomidine and lidocaine on gynecological postoperative follow up. Methods: We conducted this study based on Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA). Several scientific databases, namely Scopus, ScienceDirect, Springer Link, and PubMed, were searched for randomized, controlled studies that compared intravenous administration of dexmedetomidine and lidocaine in adult patients undergoing gynecological surgery and reported postoperative outcomes. Results: From 236 articles found, four articles were included for further analysis and discussion. Dexmedetomidine reduces the VAS score in 2 h (MD -0.30, p=0.001) 12 h (MD -0.39, p=0.004), and 24 h (MD -0.15, p=0.03) after operation compared to lidocaine. Additionally, combination of dexmedetomidine and lidocaine further reduces the VAS score in 2 h (MD -0.70, p<0.001) and 12 h (MD - 0.81, p=0.03) after operation compared to dexmedetomidine alone. Conclusion: Intravenous administration of dexmedetomidine is more potent in reducing postoperative pain after gynecological surgery compared to lidocaine. However, the combination of intravenous lidocaine and dexmedetomidine provides the best pain management compared to lidocaine or dexmedetomidine alone. Keywords: Dexmedetomidine- Lidocaine- Intravenous Anesthetic- Gynecological Surgery- Postoperative Evaluation- Systematic Review- Meta-analysis Share Link | Plain Format | Corresponding Author (Aiman Hilmi Asaduddin)

28	Medical : basic science, clinical, translational research, medical education, and miscellaneous	ABS-40
Differences in Clinical and Laboratory Features of Pregnant and Non-Pregnant Women with Hospitalized COVID-19 in Indonesia Novika RGH1, Ilyas MF2*, Triniputri WY2, Pradipta IMEW2, Ksmawati NWPS2, Wahidah NJ1, Hartono3, Yunus A4, Lanjar5 1. Midwifery Study Program, Faculty of Medicine, Universitas Sebelas Maret, Surakarta, Indonesia 2. Department of Medicine,, Faculty of Medicine, Universitas Sebelas Maret, Surakarta, Indonesia 3. Department of Physiology, Faculty of Medicine, Universitas Sebelas Maret, Surakarta, Indonesia 4. Department of Agrotechnology, Faculty of Agriculture, Universitas Sebelas Maret, Surakarta, Indonesia 5. National Research and Innovation Agency, Jakarta, Indonesia Abstract Further research on COVID-19 infection in pregnancy is important because of the high incidence, severity, and complications. This study was conducted to further investigate the differences in clinical and laboratory features between pregnant and non-pregnant women with hospitalized COVID-19. This observational study with a cross-sectional approach involved 245 inpatient confirmed COVID-19 patients who were admitted to the Universitas Sebelas Maret (UNS) Hospital, Indonesia during March 2020 until May 2022. 72 samples were classified as pregnant group and 173 were in the non-pregnant group. This study uses a medical record (MR) which is used to collect all demographic, clinical, and laboratory data. There was no statistically significant difference in demographics except in hospitalization status. Clinically, differences (p<0.05) were found in symptoms (cough, fatigue, and shortness of breath) and there were no significant differences in length of stay and other symptoms. The laboratory features also found significant differences (p<0.05) in white cell count (WCC), absolute lymphocyte count (ALC), high fluorescence lymphocyte count (HFLC), lymphocyte %, neutrophil %, neutrophil lymphocyte ratio (NLR), red cell count (RCC), hemoglobin (Hb), hematocrit (Hct), platelet count (PC), prothrombin time (PT), international normalized ratio (INR), D-Dimer, and sodium (Na). Multivariate analysis also found WCC, lymphocyte %, HFLC, neutrophil %, PT, INR, D-Dimer, Creatinine, Potassium (K) as predictors of length of stay. The differences between pregnant and non-pregnant women were found, especially in laboratory features, this can be the basis for the development of further studies and decision making in the management of COVID-19 infection, especially in pregnancy. Keywords: Keywords: COVID-19, Pregnancy, Laboratory Features, Indonesia Share Link | Plain Format | Corresponding Author (Nurul jannatul Wahidah)

29	Medical : basic science, clinical, translational research, medical education, and miscellaneous	ABS-42
ASSOCIATION OF NSP4 MUTATION AND VP4 ROTAVIRUS GENOTYPE IN CHILDREN WITH SEVERE-MODERATE DIARRHEA Elsa Fitri Ana, Rury Mega Wahyuni, Laura Navika Yamani, Zayyin Dinana, Devi Oktafiani, Ni Luh Ayu Megasari, Maria Inge Lusida, Juniastuti, Soetjipto The Doctoral Program, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia- 2 Institute of Tropical Disease, Universitas Airlangga, Surabaya, Indonesia- 3 Department of Medical Biochemistry, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia- 4 Department of Microbiology, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia- 5 Indonesia-Japan Collaborative Research Center for Emerging and Re-emerging Infectious Diseases, Universitas Airlangga, Surabaya, Indonesia- 6Community Education, Faculty of Education, Universitas Negeri Jakarta, Jakarta, Indonesia Abstract Rotavirus is the main cause of severe acute diarrhea among children. NSP4 has a role in the development of secretory diarrhea. NSP4 genotype is divided into 21 genogroups (E1-E21). Information related to rotavirus infection and the role of NSP4 pathogenesis in human has not been described as clear information about the association between NSP4 and VP4 is still limited. To determine the genotype and mutation of NSP4 and to analyze the mutation of NSP4 with VP4 genotype and diarrhea severity. A total of 51 rotavirus-positive samples were collected from children with acute diarrhea between August-Dec 2016 and June-August 2018 from 2 hospitals and 2 primary healthcare in Bandar Lampung, Indonesia. The severity of diarrhea data was collected by observation, interviewing parents or guardians, and from medical records based on Ruuska and Vesikari score. Identification of VP4 gene was performed using primers from the WHO Manual of RV detection and characterization methods protocols. P types of these samples were determined by sequencing methods. Amplification DNA for NSP4 gene was carried out using the primers described before. Amplified viral genes were subjected to sequence analysis. In this study, amino acids substitution was found in H1, H2, H3 domain, enterotoxin region, VP4-binding site, and VP6-binding site from E1 and E2 genotype. Unusual combination occured between P[8] genotype and E2 with amino acid substitution at position 72 in children with severe diarrhea. The enterotoxin region mutation at position 129 and hydrophobic domain H1 at position 14 mostly occurred in NSP4 sequence associated with P[4] and in children with severe diarrhea. This finding indicates that amino acids variation in NSP4 sequence related to VP4 genotype, but no association with diarrhea severity. Keywords: NSP4, mutation, VP4 genotype, severity Share Link | Plain Format | Corresponding Author (elsa fitri ana)

30	Medical : basic science, clinical, translational research, medical education, and miscellaneous	ABS-44
Bibliometric Analysis Moringa Oleifera on Atherosclerosis Rachmi Fauziah Rahayu1*, Nanang Wiyono2, Yunia Hastami2, Siti Munawaroh2, Ida Prista Maryetty1, Bambang Purwanto3 Radiology Department, Faculty of Medicine Universitas Sebelas Maret / Dr. Moewardi General Hospital Abstract Background: Moringa Oleifera is one of the plants with many benefits that can possibly be used in the system of medication due to its hypoglycemic activity of its polyphenol areas. One of its functions is to prevent atherosclerosis by inhibiting the production of ROS. Objectives: This study is a bibliometric analysis of the effect of Moringa Oleifera on atherosclerosis. The study in this research includes research trends and future research opportunities regarding Moringa Oleifera on atherosclerosis. Methods: 1051 metadata articles on Moringa oleifera relation to atherosclerosis were extracted from Scopus database. These articles were published from 2012 to 2022. Results: The literature accepted contributions from all over the world with the most productive countries being India, China and Nigeria. In the analysis of the study, the most productive authors were also recorded, namely Oboh, G- Oleyel, SI- and Dey S. Some of the more frequently cited themes, shown by keywords such as Oxidative stress, moringa oleifera and diabetes, indicate that there have been numerous research progressing on these themes. Conclusion: Regarding research on moringa oleifera and atherosclerosis, there are still plenty of research topics that has not been widely covered, mainly those related to streptozocin, dyslipidemia, apoptosis, etc, which might be an opportunity for research conduct scope. Keywords: Bibliometrics, Moringa oleifera, Atherosclerosis Share Link | Plain Format | Corresponding Author (Rachmi Fauziah Rahayu)

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