Neutrophil to Lymphocyte Ratio is Associated with Mid Term BPV in Hypertensive COVID-19 Patients Widi VSN (a*), Myrtha R (a, b), Hananto AZA (a, c), Ardyanto TD (a, d) and Maulidya T (a)
a) Faculty of Medicine, Sebelas Maret University, Indonesia
b) Department of Cardiology and Vascular Medicine, Sebelas Maret University Hospital, Indonesia
c) Department of Anesthesiology and Intensive Therapy, Sebelas Maret University Hospital, Indonesia
d) Department of Clinical Pathology, Sebelas Maret University Hospital, Indonesia
Abstract
Neutrophil-to-lymphocyte (NLR) is an inexpensive and feasible inflammatory marker. Inflammation has a key role in pathogenesis and progression of COVID-19 with hypertension. Blood pressure control in hypertension is influenced by blood pressure variability. A total of 192 COVID-19 patients with hypertension who were administered to Sebelas Maret University Hospital in June 2020 to February 2022 were included in this observational analytical study with a cross-sectional approach. Data were analyzed using Spearman or Pearson correlation analysis. Comparative analysis of independent T-test or Mann Whitney were used on numerical variables and Chi-Square test on categorical variables. There is a positive (unidirectional) and significant correlation (r = 0,223, p= 0,002) between the NLR dan blood pressure variability in COVID-19 patients with hypertension at Sebelas Maret University Hospital. There was a significant difference in the variables of admission oxygen saturation <93% (p<0.001) and mortality (p<0.001) which were found higher in patients with high NLR levels (>5.8) than normal NLR levels (<5.8). This study showed that admission NLR is weakly and positively correlated with blood pressure variability in COVID-19 patients with hypertension at Sebelas Maret University Hospital. An increase of admission NLR above the upper normal limit, can elevate the blood pressure variability, therefore it needs to be considered.
