ASSOCIATED RISK FACTORS OF RAISED D-DIMER IN COVID-19 PATIENTS WITH DIABETES MELLITUS Myrtha R (1), Lukas GA (2*), Ayusari AA (3), and Wijayanto MA (2)
1Department of Cardiovascular, Faculty of Medicine, Sebelas Maret University, Indonesia
2Clinical Clerkship, Faculty of Medicine, Sebelas Maret University, Indonesia
3Department of Nutrition, Faculty of Medicine, Sebelas Maret University, Indonesia
*USER-4
Abstract
Abnormal coagulation function has been linked to the advancement of COVID-19 and diabetes mellitus (DM). However, the association of elevated D-dimer in COVID-19 patients with DM is unclear. This study aims to determine risk factors of raised D-dimer in COVID-19 patients with DM at Sebelas Maret University Hospital. This retrospective study statistically analysed the risk factors of 87 COVID-19 patients with DM who were admitted to Sebelas Maret University Hospital from March 2020 to January 2021. Data were collected from patients^ medical records. Binary logistic regression was applied to determine the association between potential variables on D-dimer. Among 87 patients, 70 had elevated D-dimer, while 17 had normal D-dimer. Age, admission oxygen saturation, patient outcome, newly diagnosed diabetic patients, admission plasma glucose levels and C-reactive protein (CRP) were significantly associated with D-dimer (p = 0.017, 0.026, 0.001, 0.011, 0.036 and 0.009, respectively). However, increasing age (odds ratio [OR] 1.098 and 95% confidence interval [CI] 1.009 to 1.195- p = 0.030) was associated with an increased likelihood of D-dimer elevation, while newly diagnosed diabetic patients (OR 0.205, CI 0.052 to 0.806- p = 0.023) were associated with a reduced likelihood of D-dimer elevation in COVID-19 patients with DM. Older COVID-19 diabetic patients are prone to have higher levels of D-dimer. Therefore, they can be in a hypercoagulable state with a worse prognosis.
Keywords: COVID-19, diabetes mellitus, D-dimer
Topic: Medical : basic science, clinical, translational research, medical education, and miscellaneous
