Study Epidemioloy TB MDR and Complication in Brain and Spine
Lina Handayani Rachmi Fauziah Rahayu

University Sebelas Maret Surakarta, Indonesia

Abstract

The World Health Organization (WHO) estimates that each year there are 9 million new TB cases. Annually, TB kills approximately 1.8 million people, making it second only to HIV/AIDS as the leading cause of death from infectious diseases. Among those infected with M. tuberculosis, approximately 50 million are infected with drug-resistant strains. Worldwide, an estimated 5,000,000 cases of MDR-TB emerge each year (5.3% of all new and previously treated TB cases), resulting in 110,000 deaths. MDR-TB is tuberculosis due to organisms that show high-level resistance to both isoniazid and rifampicin, with or without resistance to other anti-TB drugs. The problem of multidrug-resistant tuberculosis has also been identified in patients with tuberculous in the central nervous system (CNS) including the brain and spine tuberculous. Multidrug-resistant CNS tuberculous is often associated with a poor prognosis. CNS tuberculosis is a devastating disease of the central nervous system. It primarily affects the meninges of the brain and spinal cord along with adjacent brain parenchyma. The thoracic spine is involved in 50% of spinal tuberculosis. Whereas the lumbar and cervical spine are each involved in 25% of cases. CNS tuberculosis can manifest in a variety of forms, including tuberculous meningitis, tuberculomas, tuberculous abscesses, and miliary tuberculosis. A meticulous cytologic analysis of cerebrospinal fluid, neuroimaging of the brain and spine, and an appropriate clinical setting are the key factors that help the diagnosis.

Keywords: Keywords: CNS Tuberculosis, multidrug-resistant tuberculosis, brain and spine

Topic: Medical : basic science, clinical, translational research, medical education, and miscellaneous