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Moringa Leaves (Moringa oleifera, Lam.) as a Potential Prophylaxis and Therapy of Steatosis and Liver Inflammation Medical Doctor Profession Education, Sebelas Maret University Abstract Metabolic syndrome can manifest on hepatic steatosis and inflammation characterized by increased expression of TNF-α-. Moringa is reported to be one of those therapeutic agents for metabolic syndrome. This study aims to determine the effect of ethanolic extract of Moringa leaves on hepatic steatosis and TNF-α- expression in metabolic syndrome rats. This laboratory experimental research used 30 Rattus norvegicus as research subjects, divided into 5 groups: NC as the normal control group- MS as the metabolic syndrome group receiving a high-fat diet and STZ-NA injection- I1, I2, and I3 as the metabolic syndrome group receiving Moringa leaf extract at a dose of 150 mgKgBW-1, 250 mgKgBW-1, and 350 mgKgBW-1, respectively. The percentage of steatosis was calculated, analyzed with OneWay ANOVA test, followed by Tukey HSD post-hoc test. TNF-α- expression was calculated using the IDS score, analyzed with Kruskal Wallis test, followed by Mann-Whitney post hoc test. Steatosis and TNF-α- expression were also tested for correlation using Spearman^s test. This study showed a significant differences in hepatic steatosis between all groups except for NC and I3, as well as I2 and I3. There were also significant differences in hepatic TNF- α- expression between all groups except for NC and I3, MS and I1, as well as I1 and I2. The correlation coefficient of Moringa leaf extract to steatosis is -0.930, and to TNF-α- expression is -0.864. Inconclusion, ethanolic extract of Moringa leaves (Moringa oleifera, Lam.) very strongly reduces steatosis and TNF-α- expression in the liver of metabolic syndrome rats. Keywords: Moringa oleifera Leaf, Steatosis, Liver TNF-α- Topic: Medical : basic science, clinical, translational research, medical education, and miscellaneous |
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