LUTEINIZING AND FOLLICLE STIMULATING HORMONE LEVEL IN FEMALE RATS POLYCYSTIC OVARIUM SYNDROME MODEL DUE TO KEBAR GRASS EXTRACT (Biophytum petersianum Klotszch)
Putri N.R. 1 *, Hidayat S.T. 2 , Widyawati M.N. 3 , Suwondo A.4 , Sudirman 5 , Ramadhian A.A.N. 3

1 Midwifery Program, Faculty of Medical, Sebelas Maret University, Indonesia
novirahardjo[at]staff.uns.ac.id

2 Medical Staff Group of Obstetric Gynecology Department, Dr. Kariadi Hospital, Semarang, Indonesia
3 Postgraduate Program, Poltekkes Kemenkes Semarang, Indonesia
4 Health and Work Safety Department, Faculty of Public Health, Diponegoro University, Semarang, Indonesia
5 Nursing Department, Poltekkes Ministry of Health Semarang - Indonesia

Abstract

ABSTRACT
Polycystic Ovary Syndrome (PCOS) has become a global problem in infertility. Manifestations of PCOS are disorders of the folliculogenesis process due to an imbalance in the hypothalamic, pituitary and ovarian cycles which is the increase of LH:FSH levels that reach 3:1 at the beginning of the fertilization period. Medical therapy for infertility is ovulation induction, but there is a side effect that is ovarian hyperstimulation syndrome. Kebar grass (Biophytum petersianum Klotzsch) is an empirical herb used as fertilizer in Indonesia. The aim of the study was to determine the effect of Kebar grass extract on LH and FSH levels in PCOS model test animals. The research method is a true experiment with a post test only design with a control group design. The research sample consisted of 5 groups, namely KN, KP (PCOS), D1, D2, and D3 (dose of 31.5- 63 and 94.5 mg/kgbw). The result of the study was tested with a non-parametric test of Kruskall Wallis because the research data unnormally distributed. Kebar grass extract can reduce the decrease in LH levels and help increase the body^s FSH with values of 0.007 and 0.013 . The glycoprotein content in kebar grass which has the same atomic weight as PMSG is thought to be one of the main factors. PMSG is a complex glycoprotein that has a high function of FSH and low LH activity, so that the serum hormone can be used to increase ovulation by stimulating the growth of follicles in the ovaries.

Keywords: Keywords: polycystic ovary syndrome, Luteinizing Hormone, Follicle Stimulating Hormone (FSH), Kebar Grass

Topic: Medical : basic science, clinical, translational research, medical education, and miscellaneous