Association of Mid Term Blood Pressure Variability with In-Hospital Mortality in Hypertensive COVID-19 Patients
Maulidya T (a*), Myrtha R (a, b), Hananto AZA (a,c), Prabaningtyas HR (a,d), Widi VSN (a)

a) Faculty of Medicine, Sebelas Maret University, Indonesia
b) Department of Cardiology and Vascular Medicine, Sebelas Maret University Hospital, Indonesia
c) Department of Anesthesiology and Intensive Therapy, Sebelas Maret University Hospital, Indonesia
d) Department of Neurology, Sebelas Maret University Hospital, Indonesia

Abstract

Blood pressure variability is a biomarker that affects the clinical outcome of COVID-19 patients. COVID-19 patients with hypertension have a higher risk of death than patients without comorbidities. Blood pressure control in hypertension is influenced by blood pressure variability. This study aims to evaluate the relationship between blood pressure variability and in-hospital mortality in COVID-19 patients with hypertension. This study was an observational analytical study with a cross-sectional approach. This study analyzed 191 COVID-19 patients with hypertension who were administered to Sebelas Maret University Hospital in June 2020 to February 2022. Data were analyzed using logistic regression multivariate analysis and comparative analysis of independent T-test or Mann Whitney on numerical variables and Chi-Square test on categorical variables. p<0,05 is considered significant. There was no significant relationship between blood pressure variability and in-hospital mortality in COVID-19 patients with hypertension from the multivariate analysis (SD SBP (p=0,620), SD DBP (p=0,940), CV SBP (p=0,868), CV DBP (p=0,980)). Meanwhile, there was a significant relationship between mean SBP (p=0,014), age (p=0,018) and admission oxygen saturation (p<0,001) and in-hospital mortality. There is no significant relationship between blood pressure variability and in-hospital mortality of COVID-19 patients with hypertension.

Keywords: Blood pressure variability, in-hospital mortality, COVID-19, hypertension

Topic: Medical : basic science, clinical, translational research, medical education, and miscellaneous