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ASSOCIATED RISK FACTORS OF RAISED D-DIMER IN COVID-19 PATIENTS WITH DIABETES MELLITUS 1Department of Cardiovascular, Faculty of Medicine, Sebelas Maret University, Indonesia Abstract Abnormal coagulation function has been linked to the advancement of COVID-19 and diabetes mellitus (DM). However, the association of elevated D-dimer in COVID-19 patients with DM is unclear. This study aims to determine risk factors of raised D-dimer in COVID-19 patients with DM at Sebelas Maret University Hospital. This retrospective study statistically analysed the risk factors of 87 COVID-19 patients with DM who were admitted to Sebelas Maret University Hospital from March 2020 to January 2021. Data were collected from patients^ medical records. Binary logistic regression was applied to determine the association between potential variables on D-dimer. Among 87 patients, 70 had elevated D-dimer, while 17 had normal D-dimer. Age, admission oxygen saturation, patient outcome, newly diagnosed diabetic patients, admission plasma glucose levels and C-reactive protein (CRP) were significantly associated with D-dimer (p = 0.017, 0.026, 0.001, 0.011, 0.036 and 0.009, respectively). However, increasing age (odds ratio [OR] 1.098 and 95% confidence interval [CI] 1.009 to 1.195- p = 0.030) was associated with an increased likelihood of D-dimer elevation, while newly diagnosed diabetic patients (OR 0.205, CI 0.052 to 0.806- p = 0.023) were associated with a reduced likelihood of D-dimer elevation in COVID-19 patients with DM. Older COVID-19 diabetic patients are prone to have higher levels of D-dimer. Therefore, they can be in a hypercoagulable state with a worse prognosis. Keywords: COVID-19, diabetes mellitus, D-dimer Topic: Medical : basic science, clinical, translational research, medical education, and miscellaneous |
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