Differences in Clinical and Laboratory Features of Pregnant and Non-Pregnant Women with Hospitalized COVID-19 in Indonesia Novika RGH1, Ilyas MF2*, Triniputri WY2, Pradipta IMEW2, Ksmawati NWPS2, Wahidah NJ1, Hartono3, Yunus A4, Lanjar5
1. Midwifery Study Program, Faculty of Medicine, Universitas Sebelas Maret, Surakarta, Indonesia
2. Department of Medicine,, Faculty of Medicine, Universitas Sebelas Maret, Surakarta, Indonesia
3. Department of Physiology, Faculty of Medicine, Universitas Sebelas Maret, Surakarta, Indonesia
4. Department of Agrotechnology, Faculty of Agriculture, Universitas Sebelas Maret, Surakarta, Indonesia
5. National Research and Innovation Agency, Jakarta, Indonesia
Abstract
Further research on COVID-19 infection in pregnancy is important because of the high incidence, severity, and complications. This study was conducted to further investigate the differences in clinical and laboratory features between pregnant and non-pregnant women with hospitalized COVID-19. This observational study with a cross-sectional approach involved 245 inpatient confirmed COVID-19 patients who were admitted to the Universitas Sebelas Maret (UNS) Hospital, Indonesia during March 2020 until May 2022. 72 samples were classified as pregnant group and 173 were in the non-pregnant group. This study uses a medical record (MR) which is used to collect all demographic, clinical, and laboratory data. There was no statistically significant difference in demographics except in hospitalization status. Clinically, differences (p<0.05) were found in symptoms (cough, fatigue, and shortness of breath) and there were no significant differences in length of stay and other symptoms. The laboratory features also found significant differences (p<0.05) in white cell count (WCC), absolute lymphocyte count (ALC), high fluorescence lymphocyte count (HFLC), lymphocyte %, neutrophil %, neutrophil lymphocyte ratio (NLR), red cell count (RCC), hemoglobin (Hb), hematocrit (Hct), platelet count (PC), prothrombin time (PT), international normalized ratio (INR), D-Dimer, and sodium (Na). Multivariate analysis also found WCC, lymphocyte %, HFLC, neutrophil %, PT, INR, D-Dimer, Creatinine, Potassium (K) as predictors of length of stay. The differences between pregnant and non-pregnant women were found, especially in laboratory features, this can be the basis for the development of further studies and decision making in the management of COVID-19 infection, especially in pregnancy.
Keywords: Keywords: COVID-19, Pregnancy, Laboratory Features, Indonesia
Topic: Medical : basic science, clinical, translational research, medical education, and miscellaneous
