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1	Biomedical Science	ABS-6
FLAVONOID-RUTIN EFFECT TO BLOOD GLUCOSE LEVEL AND PANCREAS REGENERATION IN DIABETIC RATS IIS INAYATI RAKHMAT, EUIS RENI YUSLIANTI, TEJA KOSWARA Faculty of medicine, Universitas Jenderal Achmad Yani Cimahi Abstract Diabetes mellitus is chronic metabolic disorder characterized by hyperglycemic state triggers by the formation of cells free radical. Rutin as a flavonoid or secondary antioxidant can increase insulin secretion and stimulate pancreatic progenitor cells. This study aims to analyze the effect of flavonoid-rutin to decrease blood glucose levels and pancreas regeneration in diabetic rats induced by streptozotocin. Research model was a laboratory experimental and total sample 25 experimental animals consisting of 5 groups those are negative control (NC), positive control (PC), Flavonoid-flavonoid-rutin 25mg/kgBW (P1), Flavonoid-rutin 50mg/kgBW (P2), and Flavonoid-rutin 100mg/kgBW (P3). The study was conducted for 17 days by examination of blood glucose levels and pancreas regeneration. Data were analyzed Anova and Duncan (P<0,05). The results showed flavonoid-rutin 50 mg/kgBW can reduce blood glucose levels and regenerate the pancreas because has the ability to reduce free radicals that increase in conditions of hyperglycemia. Keywords: Diabetes, Blood glucose, Pancreatic regeneration, Flavonoid Share Link | Plain Format | Corresponding Author (Iis Inayati Rakhmat)

2	Biomedical Science	ABS-12
The Effect of pH on The Activity Of Bacteriocin From Lactobacillus acidophilus On The Growth Of Salmonella typhi Elizabeth Noviana Lumban Raja (a), Siska Telly Pratiwi (b*), Alexander Siagian (c) a) Medicine Study Program, Faculty of Medicine, Universitas Jenderal Achmad Yani, Jenderal Sudirman Street, Cibeber, South Cimahi, Cimahi City, West Java, Indonesia 40531 b) Department of Microbiology, Faculty of Medicine, Universitas Jenderal Achmad Yani, Jenderal Sudirman Street, Cibeber, South Cimahi, Cimahi City, West Java, Indonesia 40531 *siska.telly[at]lecture.unjani.ac.id c) Department of Anesthesiology and Intensive Therapy, Faculty of Medicine, Universitas Jenderal Achmad Yani, Jenderal Sudirman Street, Cibeber, South Cimahi, Cimahi City, West Java, Indonesia 40531 Abstract Typhoid fever is one of the most serious infectious diseases in Indonesia. Antibiotic resistance is one of the problems associated with the treatment of typhoid fever. L.acidophilus produces antimicrobial substances, one of which is bacteriocin. Bacteriocin has bactericidal and bacteriostatic activity. The aim of this study was to determined the activity of bacteriocin from L. acidophilus against Salmonella typhi in vitro as antimicroba. The design of this study was laboratory experimental with post test only control group design using the Kirby-Bauer agar diffusion method on Mueller Hinton Agar (MHA). The bacteriat of this study were S. typhi ATCC 6539 and bacteriocin from L. acidophilus ATCC 4356 in various pH (2, 4, 6, 8, 10, and 12). The result of observation was carried out by measuring the inhibition zone in each treatment. The result showed bacteriocin from L. acidophilus at pH 2 had an inhibition zone 4.91 plus minus 1.70 mm. Statistical calculation using the One Way Anova test showed hat p-value was 0.000 then continued with the Post Hoc Tukey test showed bacteriocin from L. acidophilus at pH 2 inhibited the growth of S. typhi very significant compared to kloramfenikol. The conclusion of this study is that bacteriocin from L. acidophilus can be extracted. L. acidophilus can inhibit the growth of S. typhi and has an optimal pH, which is at pH 2 with a weak category of inhibitory strength. The bacteriocin L. acidophilus ATCC 4356 could not compete with chloramphenicol as the first line drug for typhoid fever. Keywords: Bacteriocin- Lactobacillus acidophilus- Salmonella typhi Share Link | Plain Format | Corresponding Author (Elizabeth Noviana Lumban Raja)

3	Biomedical Science	ABS-18
Comparison of Influence Trypsin on The Total Colony Number of Lactobacillus sp on The Cow Milk and Soy Milk Medium Eka Noneng Nawangsih, Ana Mariana,Teja Koswara Faculty of Medicine, Universitas Jenderal Achmad Yani Abstract Soy milk has high carbohydrate levels, so soy milk can be used as an alternative medium for the growth of Lactobacillus sp. In addition, in vivo, to be able to play an optimal role, Lactobacillus sp. must be able to survive the influence of enzymes in the digestive tract, including the trypsin enzyme. This research is an experimental laboratory that aims to compare the effect of trypsin addition on the number of Lactobacillus spp colonies using the TPC (Total Plate Count) method on soy milk and cow milk media. There are four treatment groups namely soy milk and cow milk with and without the addition of trypsin enzymes, each with 3 repetitions. Calculation of the number of colonies was carried out at the 36th hour. Data were analyzed statistically using the t-independent test. The results showed that the average number of colonies of Lactobacillus sp. in soy milk is higher than cow milk, with or without the addition of trypsin. Amount of bacterial colony in the medium of soy milk is 2.5 x1018 CFU / ml, while in cow milk 4.5 x 1012 CFU / ml. The percentage average of Lactobacillus sp mortality in soy milk is lower (54.64%) than cow milk (73.04%). There was a significant difference between the percentage of Lactobacillus sp deaths. in the media of soy milk and cow milk with p-value = 0.00 (p <0.05). The conclusion of this study shows that soy milk media is better at growing Lactobacillus sp. and more resistant to trypsin enzymes when compared to cow milk. Keywords: Lactobacillus sp., soy milk, cow milk, trypsin Share Link | Plain Format | Corresponding Author (Eka Noneng Nawangsih)

4	Biomedical Science	ABS-19
The growth curve and total colonies number of Lactobacillus sp on the red guava (Psidium guajava Linnaeus) juice medium Eka Noneng Nawangsih, Putri Heryani Kusnawan, Maman Djamaludin Faculty of Medicine, Universitas Jenderal Achmad yani Abstract Probiotics are bacteria that are beneficial to human health. Probiotic drinks from cow milk medium use carbohydrates, vitamins and minerals for its fermentation process. Red guava fruit has a higher content of fructose, glucose, sucrose, vitamins (B1-B3) and phosphorus and is non-cholesterol than cow milk. This study aims to find out the total number of colonies and an overview of the growth curve of Lactobacillus sp cultured in the medium of red guava juice (Psidium guajava Linnaeus) in vitro and then compared with the Indonesian national standard for probiotic drinks (107 CFU/mL). The growth of Lactobacillus sp in red guava medium observations every 12 hours for 60 hours. The method used for calculating the number of colonies is the TPC (Total Plate Count) method then described in the form of a growth curve. The results showed the growth curve Lactobacillus sp in the media of red guava juice from the log phase until the death phase starting at the 12th hour, 24, 36, 48 to 60 with TPC amounts of 21.5x1010CFU/mL, 49x1010CFU/mL, 49.5x1010CFU/mL, 25.5 x1010CFU/mL and 13x1010 CFU/mL respectively. The stationary phase on the curve begins at the 24th to the 36th hour. The conclusion of this research is that the red guava juice media can be an excellent growth medium for Lactobacillus sp the conclusion of this research is that the red guava juice media can be an excellent growth medium for Lactobacillus sp. Keywords: colony number, growth curve, lactobacillus sp, red guava juice Share Link | Plain Format | Corresponding Author (Eka Noneng Nawangsih)

5	Biomedical Science	ABS-22
Red Cell Distribution Width as Mortality Predictor in Patients with Acute Coronary Syndrome Nizamuddin U, Kevin K, Vita M, M. Shidqi, Arinta S, Sherly Y, Prihadi E.w Cardiology and Vascular Medicine Department Dustira Army Hospital Cardiology and Vascular Medicine Department Udayana Army Hospital Faculty of Medicine Jenderal Ahmad Yani University Abstract Introduction. Inflammation plays important role in atherosclerosis which is the primary mechanism in acute coronary syndrome (ACS). Red cell distribution width (RDW) as a consequence of systemic inflammation has been researched to be associated with morbidity and mortality in ACS. There are little data available about the association between RDW levels with GRACE and TIMI risk score. Objectives. Purpose of this study was to determine the association between RDW with GRACE and TIMI score in ACS patients. Method. A total of 1000 ACS patients were recruited into this study retrospectively from patients that admitted to Cardiology Department at Dustira Army Hospital. Patient assessment and medical record review were performed from January 2019 to January 2020. Result. The GRACE risk score was significantly higher in the group with high RDW value compared to those with moderate and low RDW value respectively (158 (144-174), 130 (114.5-149), 124 (104-147.75), P<0.001). Similarly, TIMI score for UAP, NSTEMI and STEMI were significantly higher in the group with high RDW value compared to those with moderate and low RDW value respectively (4 (3-4), 3 (3-4), 3 (3-3), P<0.001), (5 (4-5), 4, 4 (4-5), P<0.001) and (7 (5-8), 5 (5-6), 6 (5-6), P<0.001). Moreover, both GRACE (r=0.347, P<0.001) and TIMI UAP, NSTEMI and STEMI (r=0.161, r=0.263, r=0.295, P<0.001) score showed a significant positive correlation with RDW respectively. Conclusion. RDW is convenient, inexpensive and reproducible biomarker for ACS prognosis. Keywords: Red cell distribution width, acute coronary syndrome, GRACE score, TIMI score Share Link | Plain Format | Corresponding Author (Nizamuddin Ubaidillah)

6	Biomedical Science	ABS-23
DISFUNGSI ENDOTEL SEBAGAI TITIK AWAL ATEROSKLEROSIS dr Nizamuddin Ubaidillah Sp.JP FIHA Cardiology and Vascular Medicine Department Udayana Army Hospital Cardiology and Vascular Medicine Department Dustira Army Hospital Faculty of Medicine Jenderal Ahmad Yani University Abstract Penyakit jantung merupakan penyebab angka kematian yang tertinggi di dunia. 48% kematian di dunia yang disebabkan oleh penyakit yang tidak menular disebabkan oleh penyakit kardiovaskular. Prevalensi PJK di Indonesia tahun 2013 berdasarkan diagnosis dokter sebesar 0,5%, sedangkan prevalensi penyakit gagal jantung berdasarkan diagnosis dokter sebesar 0.13%.7 Hasil penelitian kohort di Pusat Jantung Nasional Harapan Kita dan 5 rumah sakit di Indonesia di tahun 2006 menunjukkan bahwa angka kematian karena penyakit jantung dan pembuluh darah di rumah sakit adalah sekitar 6-12 % dan angka re-hospitalisasi sebesar 29%. Penyakit jantung ini terutama disebabkan oleh atherosklerosis yaitu suatu proses penimbunan lemak dan matriks tunika intima, yang diikuti oleh pembentukan jaringan ikat pada dinding pembulPerkembangan atherosklerosis terjadi secara bertahap, disebabkan interaksi antara faktor-faktor risiko, disfungsi endothel, oksidasi lemak (inflamasi) yang diawali siklus akumulasi lemak dalam ruang sub endothelialuh arteri. Adanya disfungsi endothel akan menyebabkan mudahnya terjadinya perlukaan permukaan endothel oleh faktor mekanik maupun kimiawi seperti tingginya shear stres, tingginya stres oksidatif, merokok, dan resistensi insulin. Disfungsi endotel dicirikan dengan perubahan regulasi fungsi endotel yang menghasilkan ketidakseimbangan produksi dari faktor relaksasi dan kontraksi, mediator prokoagulan dan antikoagulan, atau substansi promosi dan inhibisi pertumbuhan Keywords: Aterosklerosis, disfungsi endotel, anti inflamasi, stres oksidsatif Share Link | Plain Format | Corresponding Author (Nizamuddin Ubaidillah)

7	Biomedical Science	ABS-24
Analysis of Antibacterial and Antioxidant Activities of Single Bulb of Garlic Fermented Into Black Garlic Lia Siti Halimah, Eka Noneng Nawangsih, Khomaini Hasan Faculty of Medicine, Univ Jenderal Achmad Yani Abstract Single black garlic is the result of single garlic fermentation which produces black color as a result of the fermentation process at 80 C for 15 days. As it is known that garlic has pharmacological properties, but the properties possessed by black garlic cannot be separated from the result of heating during the fermentation process. This study aims to determine the differences in antibacterial and antioxidant activity in single garlic and single black garlic. The design of this study was a pure laboratory experimental study with a Post Test Only Control Group research design. In this study, the focus was to determine the antioxidant and antibacterial activity against Streptococcus mutans, Streptococcus pyogenes and Enterococcus faecalis on single garlic and single black garlic. Testing for antibacterial activity using the Kirby-Bauer diffusion method, while antioxidant testing was carried out by the 2,2-diphenyl-1-picrylhydrazyl (DPPH) method. The results showed that there was a significant increase in the antibacterial activity of black garlic against Streptococcus mutans and Enterococcus faecalis (P <0.05). Meanwhile, the increase in antibacterial activity against Streptococcus pyogenes showed insignificant differences (p> 0.05). Likewise, the increase in antioxidant activity of single black garlic DPPH was significantly different from single garlic (P <0.05). Overall, the results of this study indicate that the garlic fermentation process by heating at 80 C for 15 days can cause changes in colour, texture, taste, and significantly increase the antibacterial and antioxidant activities. Keywords: Garlic, Black garlic- Fermentation- Antibacterial Activity- Antioxidant Activity Share Link | Plain Format | Corresponding Author (Lia Siti Halimah)

8	Biomedical Science	ABS-25
ANESTHESIA MANAGEMENT ON CONGENITAL DIAPHRAGMATIC HERNIA Galantry Ahmad, Rudi Kurniadi, Erwin Pradian, Iwan Fuadi, Suwarman, Reza Sudjud Residen Anestesi Unpad Abstract Background: Congenital diaphragmatic hernias are caused by a defect in the closure of the pericardioperitoenal canal. It is a particular challenge for anesthetists during the perioperative management of patients with diaphragmatic hernias such as intraoperative complications including hypoxia and hypercarbia. Mortality remains high due to pulmonary hypoplasia and pulmonary hypertension. Case: An 8-day-old boy with a diagnosis of congenital diaphragmatic hernia underwent laparotomy to repair the diaphragmatic defect cap. The patient presented with shortness of breath from chest X-ray and found a diaphragmatic hernia. The preoperative assessment shows the patient is still in optimal condition. General anesthesia technique was performed with controlled breath intubation. Monitoring is done with, NIBP, EKG, SpO2. Postoperatively the patient is stable and laboratory tests show results within normal limits and the patient is extubated after 5 days of treatment at the NICU and returns after 11 days of treatment in the room Discussion: There are various challenges by an anesthesiologists during management of such cases which include intraoperative complications including hypoxia and hypercarbia. Mortality remains high because of associated pulmonary hypoplasia and pulmonary hypertension Keywords: congenital, diaphragmatic, hernia, hypoxia, pulmonary hypoplasia Share Link | Plain Format | Corresponding Author (Galantry Ahmad Azhari)

9	Biomedical Science	ABS-28
Transarterial Chemoembolization for Hepatocelullar Carcinoma dr. Puspitasari Sandra Wijaya, dr. Hilman, Sp.Rad(K) Departemen Radiologi Fakultas Kedokteran UNPAD-RSHS. Bandung Jl. Pasteur no.38. Bandung 40161 Abstract Background Transarterial Chemoembolization (TACE) combines transarterial delivery of chemotherapeutic agents to the tumor bed, which is followed by embolization of the tumor vascularity. Transcatheter arterial chemoembolization (TACE) has been recognized as an effective palliative treatment option for patients with advance HCC. Hepatocellular carcinoma (HCC) is the fifth most common cancer that predominantly occurs in liver cirrhosis of patients. It requires staging systems to design the treatments. The Barcelona Clinic Liver Cancer (BCLC) staging system is the most common guideline, which is used for HCC management. For Barcelona Chlinic Liver Cancer (BCLC) stage B (intermediate HCC), Transarterial Chemoembolization (TACE) is the standard treatment. TACE is shown to improve median survival from 16 to 20 months. Objective This study assesses the effectiveness of Transarterial Chemoembolization (TACE) in hepatocellular carcinoma cases. Method Transarterial Chemoembolization (TACE) for Hepatocellular Carcinoma Result A patient, 66-year-old male, visited Hasan Sadikin Hospital (RSHS) Bandung to undergo TACE.The patients complaints were severe nausea and the feeling of being tired quickly since the last 3 months. The patient had a history of Hepatitis B 10 years ago. The examination was continued with ultrasonography (USG) and the result showed a lesion in the right lobe of the liver. After that, the medical imaging was enhanced by performing a computed tomography scan (CT scan) and a 6,4 x 5,09 x 4,1 cm inhomogeneous isodense lesion was found in the 4th segment of the right liver, which was supporting a hepatocellular carcinoma. The HCC was classified according to the BCLC and Child-Pugh criteria as hepatocellular carcinoma stage B Child-Pugh A. Furthermore, the patient was treated with TACE at the RSHS Bandung Hospital. Conclusion There was a decrease in the size of the mass, shows the success TACE. Keywords: Transarterial Chemoembolization Share Link | Plain Format | Corresponding Author (Puspitasari Sandra Wijaya)

10	Biomedical Science	ABS-31
Temperature Optimization and Inhibition Test of Lactobacillus acidophilus Bacteriocins against Salmonella typhi Bacteria Siska Telly Pratiwi, dr., M.Kes (a*), Muhammad Bagas Aditya (a) dan Endah Hamidah, dr., Sp.PA., M.Kes (b) a) Department of Microbiology, Universitas Jenderal Achmad Yani b) Department of Anatomy Pathology, Universitas Jenderal Achmad Yani Abstract Typhoid fever is an infection of the digestive tract caused by Salmonella typhi bacteria. Bacteriocin is an antimicrobial protein compound that is bactericidal or bacteriostatic produced by the species group of Lactic Acid Bacteria (LAB). One of the LAB which is a digestive tract microbiota is Lactobacillus acidophilus. Bacteriocin protein have an optimum temperature range to provide antimicrobial effect. The aimed of this study was determine the temperature optimization of L.acidophilus bacteriocins on S.typhi growth. The design of this study was a laboratory experimental using the Kirby-Bauer method. The objects of this study were S.typhi ATCC 6539 and the bacteriocin extract of L.acidophilus ATCC 4356 with a temperature treatment of 40o, 60o, 80o, 100o, and 121oC. The results of research observations were carried out by measuring the diameter of the inhibition zone in each treatment. The inhibition zone diameter in each treatment was compared with the inhibition zone diameter with positive control using chloramphenicol and negative control using aquades. The preliminary test gave positive results in the presence of 3mm diameter inhibition. Bacteriocin sensitivity test to proteolytic enzymes gave negative results. This shows the inhibitory power of the preliminary test formed by the action of bacteriocins. The temperature optimization test for L.acidophilus bacteriocins did not give positive results at temperatures of 40o, 60o, 80o, 100o, and 121oC. This is due to several reasons, namely the storage and McFarland 0.5 standard setting is too small to inhibit S.typhi growth. This is evidenced by the preliminary test without McFarland arrangement which can provide 3mm diameter inhibition. The conclusion of this study is that L.acidophilus bacteriocin can be identified, extracted and inhibited the growth of S.typhi but temperature optimization has not been able to provide results because the storage and use of McFarland standards are too small. Keywords: antibacterial, bacteriocin, Lactobacilus acidophilus, Salmonella typhi, inhibition. Share Link | Plain Format | Corresponding Author (Muhammad Bagas Aditya)

11	Biomedical Science	ABS-32
ANTIHYPERURISEMIC EFFECTIVITY STUDY OF ETHANOLIC EXTRACT OF BREADFRUIT LEAVES (Artocarpus altilis) ON MICE (Mus musculus) DDY STRAIN, HIGH PURINE DIET INDUCED Maman Djamaludin*, Daswara Djajasasmita**, Nabila Khoerunnisa*** *Laboratorium Farmakologi,**Laboratorium Fisiologi,***Progam Studi Kedokteran Medical Faculty of Universitas Jenderal Achmad Yani Abstract Hyperuricemia is a condition with increased in blood uric acid level . This condition causes pathological abnormalities in the form of a build up of monosodium urate crystals in body tissues. Provision of herbal medicines, one of which is of bread fruit leaves (Artocarpus altilis) thought to reduce blood uric acid level. This is the antihyperuricemic effectivity test of breadfruit leaves (Artocarpus altilis) ethanol extract against mice induced by chicken liver juice. Chicken liver juice dose of 50 mg / kgBW induces an increase in uric acid level so that it becomes hyperuricemic. The study was conducted with an experimental method with mice of 24 DDY strain which divided into 6 groups. The treatments consisted of: Negative control (G-I), positive control (G-II), admnistered of breadfruit leaves ethanol extract dose 150 mg / kgBB (G-III), dose 300 mg / kgBW (G-IV), dose 600 mg / kgBW (G-V) and allopurinol dose 13 mg / kgBW (GVI).The whole group was acclimatized for 7 days and given test material on days 8-16, on the 17 th day all groups were drawn from retro orbital veins and checking for uric acid levels. The results of the study using the Post Hoc Tukey Test showed that the level of uric acid in all treatment groups were significantly different (p <0.05). From these results it was seen that ethanol extract of breadfruit leaves (Artocarpus altilis) at a dose of 600 mg /kgBW was the most effective dose to reduce uric acid level compared to 150 mg / kg BW and 300 mg /kgBW, breadfruit leaves ethanol extract 600 mg /kgBW has the same effectivity as allopurinol dose 13 mg /kgBW. This is because breadfruit leaves have secondary metabolites namely flavonoids, alkaloids, and tryptenoids which can inhibit the xanthine oxidase enzyme so that uric acid in the blood decreased. Keywords: breadfruit leaves, chiken liver juice, hyperuricemia, allopurinol Share Link | Plain Format | Corresponding Author (Maman Djamaludin)

12	Biomedical Science	ABS-33
EFFECT OF TURMERIC RHIZOME ETHANOL EXTRACT (Curcuma Longa) ON BLOOD HEMOSTASIS TEST Rini Roslaeni(a*), Raya Agung Maha Sakti(b), M Fathan Zulfahmi(b), Maharany Rizky Yuniar(b), Evi Sovia(c), Wahyu Harihardjaja(d), Anita Liliana Susanti(a) aClinical Pathology Laboratory Fakultas Kedokteran Universitas Jenderal Achmad Yani Cimahi *rini.roslaeni[at]lecture.unjani.ac.id bMedical Study Program Fakultas Kedokteran Universitas Jenderal Achmad Yani Cimahi cPharmacology Laboratory Fakultas Kedokteran Universitas Jenderal Achmad Yani Cimahi dInternal Medicine Laboratory Fakultas Kedokteran Universitas Jenderal Achmad Yani Cimahi Abstract Turmeric (Curcuma longa) is a medicinal plant that is widely found in Asia, often used as spice or traditional medicine. Turmeric plant has dark yellow roots (rhizome) and contains various important compounds, including curcumin and ar-tumeron which play a role in inhibiting blood clotting. Currently, one of the main causes of morbidity and mortality in the world is cardiovascular disease such as stroke and coronary heart disease. The potential of turmeric which has anticoagulant properties is expected to be an alternative in prevention of cardiovascular disease. The purpose of this study was to determine the effect of ethanol extract of turmeric rhizome in vitro and in vivo on the prothombine time (PT), bleeding time (BT), and clot retraction. Subjects of in vitro study were men aged 17-20 years. History of platelet aggregation abnormalities, hemophilia, anemia and thrombocytopenia were excluded. In vivo research subjects used male mice aged 1-2 months, weighing 20-30 grams and healthy. The PT examination used tilt tube method, clot retraction examination used whole blood then left for 2 hours and the remaining serum was calculated using formula for serum volume/initial blood volume x100%, while BT examination was carried out by incising rats tail. Results showed that mean PT and BT were elongated in all test groups. The greater the dose of turmeric rhizome extract, the longer the PT and BT values. Clot retraction in the test group showed a lower mean serum percentage compared to negative controls, and the greater the extract dose given, the lower the clot retraction value. This is suspected because the active substances in turmeric rhizome extract such as curcumin and ar-tumeron can inhibit the blood clotting so that the blood hemostasis tests affected Keywords: bleeding time, curcumin, clot retraction, prothrombine time, turmeric Share Link | Plain Format | Corresponding Author (Rini Roslaeni)

13	Biomedical Science	ABS-36
QEEG And Digit Span Before And After Neurofeedback In Benzodiazepine Abuse In Treatment : A Case Series Aprilia Grace Sweetasari(1), Siti Aminah Sobana(2), Suryani Gunadharma(2), Lisda Amalia(2), Ahmad Rizal Ganiem(2), Arifah Nur Istiqomah(3), Uni Gamayani(2) (1)Departement of Neurology, Universitas Jenderal Achmad Yani (2) Departement of Neurology, Universitas Padjadjaran (3) Departement of Psichiatry, Universitas Padjadjaran Abstract Benzodiazepine is most commonly abused drug, causes brainwave abnormality and working memory disorder. Quantitative electroencephalography (qEEG) - guided neurofeedback has been used to treat substance abuse but so far limited for benzodiazepine abuse. The aim of this study was to determine the response of qEEG and its effect on working memory evaluated by digit span in benzodiazepine abuse patients before and after neurofeedback. This is a case series of four subjects with benzodiazepine abuse in treatment who underwent 15 sessions of neurofeedback training using alpha/beta2 protocol at C3 and C4 to evaluate qEEG and digit span before and after the 5th, 10th and15th sessions of neurofeedback. Although there were various responses in qEEG, all subjects reported improvement in working memory (total digit span score) before and after neurofeedback training in benzodiazepine abuse in treatment. The findings indicate that more research with larger subjects are warranted to clarify the benefits of neurofeedback training for benzodiazepine abuse patients in treatment. Keywords: benzodiazepine abuse, neurofeedback, qEEG Share Link | Plain Format | Corresponding Author (Aprilia Grace Sweetasari)

14	Biomedical Science	ABS-46
Potential Anti-Acne Ethanol Extract Tuberose Flower (Polianthes tuberosa L.) Against Propionibacterium acnes In Vitro Sayu Putu Yuni Paryati, Awan Buana, Aria Rachmatullah Faculty of Medicine, Jenderal Achmad Yani University Abstract Acne vulgaris is an inflammatory disease of the skin caused by the Propionibacterium acnes. The prevalence of acne vulgaris reached 90% in adolescents to adults in Indonesia in 2016. Tuberose flower (Polianthes tuberosa linn) is a plant with antibacterial properties. Compounds that have antibacterial properties are flavonoids, polyphenols, and steroids. This study aims to determine the anti-acne effectiveness of tuberose flower ethanol extract against the in vitro growth of P. acnes. The design of this study was an experimental laboratory using well diffusion method. Objects of this research were P. acnes ATCC 11827 and the ethanol extract of tuberose flower with a concentration of 5%, 10%, 15%, 20%, 30%, 40%, and 50% with positive control of clindamycin 10 microgram/disk and distilled water as a negative control. Determination of sample repetitions based on Federer^s formula three times. The result at a concentration of 20% was 6.41 +/- 0.11 mm and at a concentration of 50% was 11.61 +/- 0.20 mm. Based on the statistical results of One Way Anova, the value of p = 0.000 and the Post Hoc Tukey test showed that the ethanol extract of tuberose flower concentrations of 5%, 10%, 15%, 20%, 30, 40%, and 50% can inhibit the growth of P. acnes significantly compared to control (p = 0.000). The conclusion is the ethanol extract of tuberose flower (P. tuberosa linn) with concentration of 20% is Minimum Inhibitory Concentration and 50% is an effective concentration in inhibiting the growth of P. acnes bacteria in vitro. Keywords: Antibacterial, inhibition, polianthes tuberose linn, propionibacterium acnes, tuberose flower Share Link | Plain Format | Corresponding Author (Aria Rachmatullah)

15	Biomedical Science	ABS-47
ANTIBACTERIAL EFFECT OF ETHANOL EXTRACTS OF BROCCOLI LEAVES (Brassica oleracea var. italica) AGAINST Propionibacterium acnes IN VITRO Sayu Putu Yuni Paryati, Henny Juliastuti, Dandi Fery Gunawan Fakultas Kedokteran Universitas Jenderal achmad Yani Abstract Acne vulgaris is an inflammatory disease of the skin that affects 80-100% of people in the world. Acne vulgaris occur because of inflammation by the Propionibacterium acnes. Broccoli leaves (Brassica oleracea var. Italica) have an antibacterial effect. Compounds that have antibacterial effects are flavonoid, saponin, alkaloid, and steroid. This study aims to prove the antibacterial effect of ethanol extract of broccoli leaves against in vitro growth of P. acnes. This study was laboratory experimental. Objects of this study were P. acnes ATCC 11827 and ethanol extract of broccoli leaves with concentrations of 10%, 30%, 50%, 70%, 90%, and 100%. The positive control in this study was clindamycin 10 microgram/disc and DMSO 4% as negative control. Determination of sample repetitions based on Federer^s formula is 4 times. Antibacterial activity test was measured by well diffusion method. The results showed the ethanol extract of broccoli leaves does not have inhibitory power for all concentrations and it was comparable to the negative control of 0 mm. Factors that affect the results in this study could be from temperature and storage time, light exposure, and levels of active compounds in extracts. The sensitivity of P. acnes to the ethanol extract of broccoli leaves could affect the results. The other factor is technical factors such as the number of bacteria inoculated, media selection, and antibiotic carryover. Based on the results of this study, it can be concluded that the ethanol extract of broccoli leaves does not have an in vitro antibacterial effect on P. acnes growth. Keywords: Antibacterial, broccoli leaves, inhibition, Propionibacterium acnes Share Link | Plain Format | Corresponding Author (Dandi Fery Gunawan)

16	Biomedical Science	ABS-54
Effectivity of Ethanol Extract of Babadotan leaves (Ageratum conyzoides) Against Musca domestica Lutfhi Nurlaela, dr., M.Kes (a), Ali Taufan, dr., MH.Kes (b), Ranti Zalfa Husniyyah Utami (a) (a) Laboratory of Parasitology, Faculty of Medicine, Jenderal Achmad Yani University, Cimahi (b)Forensic and Medicolegal Laboratory, Faculty of Medicine, Jenderal Achmad Yani University, Cimahi Abstract The house fly, Musca domestica (M. domestica), is the largest synanthropic insect found in poor sanitation. House flies act as mechanical vectors that transmit pathogenic agents, so that an excessive increase in fly populations can cause health problems for humans. The use of synthetic chemical compounds is still the main choice in controlling the population of M. domestica, but it can trigger resistance to insects, disrupt human health, and pollute the environment. To avoid these bad effects, it can be done by developing the use of natural insecticides. One plant that has the potential to be a natural insecticide is Ageratum conyzoides (A. conyzoides) which is known as the babadotan plant. Babadotan plants contain bioactive compounds that can interfere with larval growth and development. The purpose of this study was to determine the effectiveness of the ethanol extract of babadotan leaves as a larvicide against M. domestica. This research is an experimental study with a Posttest Only Control Group Design. The ethanol extract of babadotan leaves was made in several concentrations, namely 10%, 30%, 50%, 70%, and 100% then dropped directly on the third instar larvae of M. domestica. The research data were analyzed using the One-Way ANOVA test and probit analysis. The results showed that the 10% concentration could kill 43% of larvae and the mortality rate continued to increase until it reached 97% at 100% concentration so that all concentrations of babadotan leaf ethanol extract (Ageratum conyzoides) had a larvicidal effect on instar III larvae of Musca domestica. The Lethal Concentration (LC90) value of the ethanol extract of babadotan leaves was at a concentration of 48.123%. This is due to the active compounds contained in the ethanol extract of babadotan leaves such as alkaloids, flavonoids, saponins, and steroids/triterpenoids Keywords: Ageratum conyzoides, Larvacides, LC90, Musca domestica Share Link | Plain Format | Corresponding Author (Ranti Zalfa Husniyyah Utami)

17	Biomedical Science	ABS-55
CHARACTERISTICS, NUTRITIONAL STATUS, AND LIPID PROFILE OF DYSLIPIDEMIA PATIENTS WITH MEDITERRANEAN DIET Dewi Ratih Handayani (a), Endry Septiadi (b), Iis Inayati Rakhmat (a), M Arasy Faradina, Reza Fadhil Nugraha, Rifal Aldi Anugrah, Hero Prawira (c) a) Department of Biochemistry, Faculty of Medicine, Jenderal Achmad Yani University b) Department of Nutrition, Faculty of Medicine, Jenderal Achmad Yani University c) Faculty of Medicine, Jenderal Achmad Yani University Abstract Dyslipidemia is a lipid metabolism disorder with an imbalance of lipid fraction in plasma, including increase in total cholesterol, LDL, TGA, and decrease in HDL. Changes in lipid profile levels can be influenced by several factors, namely diet, physical activity, lifestyle, age, sex, and genetics. Poor diet, such as consuming foods that contain excessive fat can cause abnormal lipid profile. The Mediterranean diet is a recommended diet for people with dyslipidemia because it contains ingredients such as unsaturated fatty acids (MUFA and PUFA), high antioxidants, and low glycemic index that improve nutritional status and lipid profile levels. This study aims to determine the characteristics, nutritional status and lipid profile levels of dyslipidemia patients with a Mediterranean diet. This research is descriptive study with cross-sectional apporach and the sample was 37 dyslipidemia patients on Mediterranean Diet collected by consecutive sampling. Nutrional status examination involved BMI which mostly the patients had obesity I- waist circumference which mostly the female patients had &#8805-80 cm and male patients had &#8804-90 cm- and lipid profile which the average level of cholesterol total 188,84 mg/dL, HDL 41,00 mg/dL, LDL 130,43 mg/dL, and TGA 117,41 mg/dL. Mediterranean Diet effects had been proved showing the normal average level of total cholesterol, HDL, and TGA meanwhile LDL level and nutritional status were abnormal. Keywords: Dyslipidemia, Lipid profile, Mediterranean diet, Nutritional status Share Link | Plain Format | Corresponding Author (M Arasy Faradina)

18	Biomedical Science	ABS-56
CHARACTERISTICS, NUTRITIONAL STATUS, AND BLOOD GLUCOSE LEVELS OF TYPE 2 DIABETES MELLITUS PATIENTS WITH MEDITERRANEAN DIET Endry Septiadi (a), Iis Inayati Rakhmat (b), Dewi Ratih Handayani (b), Reza Fadhil Nugraha (c), M Arasy Faradina (c), Nur Muhamad Rohman (c), Muhammad Akmal Rais (c) a) Department of Nutrition, Faculty of Medicine, Jenderal Achmad Yani University b) Department of Biochemistry, Faculty of Medicine, Jenderal Achmad Yani University c) Faculty of Medicine, Jenderal Achmad Yani University Abstract Type 2 diabetes mellitus (type 2 DM) is a metabolic disease due to disorders of the pancreas in producing insulin. Poor diet can cause abnormal blood glucose levels. The Mediterranean diet is a diet that is recommended for people with type 2 DM because it contains unsaturated fatty acids (MUFA and PUFA), high antioxidants, and low glycemic index that can improve nutritional status and blood glucose levels. This study aims to describe the characteristics, nutritional status, and blood glucose levels of type 2 DM patients with a Mediterranean diet. The research method used is descriptive with a cross-sectional design. The sample size was 24 patients with type 2 DM on the Mediterranean diet for one month. Sampling was done by consecutive sampling. Subject characteristics include age, gender, and level of education. The nutritional status examined included Body Mass Index (BMI) and waist circumference. The blood glucose levels checked in this study were fasting blood glucose levels. Most of the subjects were women with a mean age of 55.21 years and high school education level. Nutritional status based on BMI was obtained, namely obesity I, waist circumference obtained by female patients having a waist circumference >80cm and men having a waist circumference >90 cm. The average fasting blood glucose levels were 149.67 mg/dl. The effect of the Mediterranean diet on type 2 DM patients shows that the mean fasting blood glucose levels and nutritional status have not reached normal values. Keywords: Blood glucose levels, Mediterranean Diet, Nutritional status, Type 2 diabetes mellitus Share Link | Plain Format | Corresponding Author (Reza Fadhil Nugraha)

19	Biomedical Science	ABS-57
MEDITERRANEAN DIET AFFECTS THE REDUCTION OF SYSTOLIC BLOOD PRESSURE AND DIASTOLIC BLOOD PRESSURE IN HYPERTENSIVE PATIENTS Endry Septiadi (a), Andri Andrian Rusman (b), Achmad Hero Prawira (c), Rifal Aldi Anugrah (c), Nur Muhamad Rohman (c), Muhammad Akmal Rais (c), M Arasy Faradina (c), Reza Fadhil Nugraha (c) a) Department of Nutrition, Faculty of Medicine University of Jenderal Achmad Yani, Cimahi b) Department of Forensic, Faculty of Medicine University of Jenderal Achmad Yani, Cimahi c) Faculty of Medicine University of Jenderal Achmad Yani, Cimahi Abstract Data from the World Health Organization (WHO) in 2015 showed that around 1.13 billion people in the world had hypertension. Data in Indonesia according to Riskesdas in 2018 was 34.1% of hypertension patients. The management of hypertension can be done by modifying the dietary habit recommended by the American Heart Association (AHA), namely the Mediterranean diet. The composition of the Mediterranean diet contains high levels of PUFA, MUFA and antioxidants that can lower blood pressure sourced from vegetable and olive oil. The design of this study used an analytical method with a cohort observation of 63 hypertension subjects with a Mediterranean diet. This study aims to determine the correlation between the duration of the Mediterranean diet on systolic and diastolic blood pressure in hypertensive patients. Researchers divided the three groups based on the length of the diet in three months. Systolic and diastolic blood pressure data were analyzed using the Anova test and Duncan^s Post Hoc comparison test. The results of this study found a significant relationship with a value of p = 0.001 in the decrease in systolic blood pressure, and p = 0.010 for the decrease in diastolic blood pressure. The Mediterranean diet lowers blood pressure by improving endothelial dysfunction, suppressing oxidative stress, and improving the renin-angiotension-aldosterone system. In this study, it can be concluded that there is a significant decrease in blood pressure in hypertensive patients who are running the Mediterranean diet. Keywords: Blood pressure, Diastolic, Mediterranean diet, Systolic Share Link | Plain Format | Corresponding Author (Achmad Hero)

20	Biomedical Science	ABS-63
EFEKTIVITAS EKSTRAK ETANOL KULIT BUAH JERUK PURUT (Citrus hystrix) SEBAGAI BIOINSEKTISIDA TERHADAP NYAMUK Aedes aegypti DENGAN APLIKASI ELEKTRIK Lutfhi Nurlaela1, Lintang Pitarani2 Sutedja3 1Laboratorium Parasitologi Fakultas Kedokteran Universitas Jenderal Achmad Yani 2Program Studi Kedokteran Umum Fakultas Kedokteran Universitas Jenderal Achmad Yani 3Bagian Ilmu Kesehatan Masyarakat Fakultas Universitas Jenderal Achmad Yani Abstract Nyamuk Aedes aegypti merupakan penyebar utama demam berdarah atau Demam Berdarah Dengue (DBD), case fatality rate di Indonesia masih sangat tinggi di tahun 2017 sebesar 0.75 %. Salah satu cara untuk mencegah penyakit Demam Berdarah Dengue adalah melakukan pencegahan kontak nyamuk terhadapmanusia menggunakan obat nyamuk. Obat nyamuk yang digunakan bisamengandung bahan sintetik dan juga bisa mengandung bahan alami salah satunya menggunakan ekstrak jeruk purut. Ekstrak jeruk purut mengandung Limonene sebagai racun pernafasan nyamuk Penelitian ini bertujuan untuk efektivitas ekstrak etanol kulit buah jeruk purut dilakukan percobaan menggunakan 325 ekor nyamuk yang dibagi menjadi 5 kelompok perlakuan. Didapatkan hasil bahwa ekstrak etanol kulit jeruk purut efektif membunuh nyamuk karena kandunganLimonene mengakibatkan stimulasi berlebihan pada neuron motorik menyebabkan faskulasi otot ,berkurangnya koordinasi, konvulsi, dan paralisis. Pada penelitian ini didapatkan ekstrak etanol kulit buah jeruk purut berpotensi sebagai bioinsektisida terhadap nyamuk Aedes aegypti, dan konsentrasi ekstrak yang paling efektif adalah konsentrasi 60%. Keywords: Aedes aegypti, Ekstrak kulit buah jeruk purut, Obat nyamuk elektrik Share Link | Plain Format | Corresponding Author (Lutfhi Nurlaela)

21	Biomedical Science	ABS-64
Uji Efektivitas Ekstrak Etanol Daun Kemangi (Ocinum Sanctum) Sebagai Anti Nyamuk Elektrik Terhadap Imago Aedes aegypti Lutfhi Nurlaela1, Intan Khaerunnisa2 Hadi Jusuf3 1Bagian Parasitologi, Fakultas Kedokteran Universitas Jenderal Achmad Yani, 2Program Studi Kedokteran, Fakultas Kedokteran Universitas Jenderal Achmad Yani, 3Bagian Ilmu Penyakit Dalam, Kedokteran Universitas Jenderal Achmad Yani Abstract Nyamuk Aedes aegypty merupakan vektor penyakit Demam Berdarah Dengue (DBD) saat ini masih menjadi salah satu masalah kesehatan Indonesia. Pencegahan penyakit DBD dapat dilakukan dengan memutus penularan melalui pengendalian vektornya. Sejauh ini pengendaliaan vektor sebagian besar dengan menggunakan pestisida kimia dengan alasan praktis, namun penggunaan insektisida dengan bahan kimia berkepanjangan juga dapat menyebabkan efek toksik. Kemangi (Ocinum sanctum) adalah salah satu tanaman yang memiliki efek insektisida yang alami. Penelitian ini dilakukan untuk mengetahui efektivitas ekstrak etanol daun kemangi terhadap imago Aedes aegypti sebagai anti nyamuk elektrik, penelitian eksperimen yang dilakukan dengan tiga konsentrasi 30%, 60% dan 90%, dan kontrol negatif yang berisi akuades, tiga kali pengulangan setiap konsentrasi. Pegamatan terhadap jumlah nyamuk yang mati/pingsan setelah dipapar selama 4 jam. Hasil uji Kruskal Wallis yang dilanjutkan dengan uji Mann Whitney diketahui konsentrasi yang paling efektif adalah 90%. Analisis probit menunjukkan bahwa nilai LC50 sebesar 93,2%. Hasil tersebut menunjukkan bahwa ekstrak etanol daun kemangi efektif sebagai anti nyamuk elektrik terhadap imago Aedes agypti, hal ini berhubungan dengan kandungan bahan aktif yang terdapat didalam daun kemangi yang berperan sebagai insektisida seperti flavonoid, saponin, minyak atsiri alkaloid, dan tanin. Keywords: Aedes aegypti, Ekstrak etanol daun kemangi, obat nyamuk elektrik Share Link | Plain Format | Corresponding Author (Lutfhi Nurlaela)

22	Biomedical Science	ABS-66
SUBCRONIC TOXICITY EFFECT OF ETHANOL EXTRACT OF BITTER MELON PULP (MOMORDICA CHARANTIA L.) ON KIDNEY FUNCTION AND Welly Ratwita1, Maman Djamaludin2, Henny Juliastuti3, Dian Anggraeny4, Imas Puji Astuti5, M. Fikri A6. 1-2Departement of Pharmacology Faculty of Medicine Jenderal Achmad Yani University, INDONESIA 3Departement of Biochemistry Faculty of Medicine Jenderal Achmad Yani University, INDONESIA 4Departement of Histology Faculty of Medicine Jenderal Achmad Yani University, INDONESIA 5-6Medical Study Program Faculty of Medicine Jenderal Achmad Yani University, INDONESIA Abstract Bitter melon is a fruit that was famous for its bitter taste and contains chemical compounds that are proven to have effects such as antidiabetic, anti-inflammatory, antipyretic, and antioxidant. One of the prerequisites of a plant to be developed into a drug that is by testing the subchronic toxicity. This study goals to determine the presence of toxic effects that are not detected in the acute toxicity test. A total of 40 galur wistar rats were divided into 1 control group (C) and 3 treatment groups (T). Each group consisted of 5 male rats and female rats. Group C is only given food (pellets) and drinking water. T1, T2, and T3 groups were ethanol extract of bitter melon pulp (Momordica charantia L.) with multilevels doses 250 mg/kgbw, 500 mg/kgbw, and 1000 mg/kgbw. The observations made for 28 days included the number of death animals, relative organ weight (ROW), ureum, creatinine levels, histopatological changes in kidney. There were no deaths in the entire group and there were no significant changes in ROW (p=0,370 and p=0,394), ureum (p=0,022), creatinine levels (p=0,022, and also changes in microscopic structure. In conclusion, the ethanol extract of bitter melon pulp in this study showed toxic effect on kidney. Keywords: Momordica charantia L., sub chronic toxicity, kidney function, histopathological changes Share Link | Plain Format | Corresponding Author (Welly Ratwita)

23	Biomedical Science	ABS-72
The Comparison of Ethanol Extract Breadfruit Leaf and Glibenclamide Towards the Decreasing of Blood Glucose Levels in Rats with Diabetes Mellitus Induced by Aloxan Iis Inayati Rakhmat, Danial Ahmad Dzulfikri, Hadi Jusuf Medical Faculty, Universitas Jenderal Achmad Yani Abstract Diabetes mellitus is a disease that will increase in the future. There are many drugs used to treat this disease, but they have a bad side effect when they used for long term. Breadfruit^s leaf (Artocarpus altilis) is one of many plants that usually used as an antidiabetic by Indonesian people, because it contains quercetin, a flavonoid that can be used as antidiabetic and antioxidant. This study aimed to determine the effect of ethanol extract of breadfruit^s leaf with glibenclamide on blood glucose levels of male albino rats (Rattus norvegicus) of wistar strain induced by alloxan. This research was conducted with experimental methods using 35 male albino rats of wistar strain. They were divided into 5 groups, 1 group as a negative control, and 4 other groups induced by alloxan 120 mg/kgBW, further divided into positive control, the treatment group ethanol extract of breadfruit^s leaf 100 mg/kgBW, the treatment group glibenclamide 0,45 mg/kgBW, and the combination treatment group ethanol extract of breadfruit^s leaf 100 mg/kgBW with glibenclamide 0,45 mg/kgBW. Treatment was given for 21 days and blood glucose levels checked in the day before treatment and after treatment, to obtain the difference in blood glucose levels. The result statistical analysis of research by One-Way ANOVA test was significantly different after 21 days of treatment (p <0.05). Then continued by Post Hoc Tukey test results showed that there were not significantly different among 3 treatment groups. This happened because the breadfruit^s leaf had quercetin as an antidiabetic and antioxidant, while glibenclamide had the effect of increasing the secretion of insulin, then blood glucose levels would decrease. In conclusion ethanol extract of breadfruit^s leaf, glibenclamide and the combination treatment group capable of lowering blood glucose levels, but there were no significant differences between three treatment groups. Keywords: antidiabetic, breadfruit^s leaf, diabetes melitus, flavonoid, quercetin Share Link | Plain Format | Corresponding Author (Danial Ahmad Dzulfikri)

24	Biomedical Science	ABS-74
The Effect of Strawberries (Fragraria x ananassa) on Immediate Memory Daswara Dadjasasmita, Ibnu Ananta Nugraha, Ali Taufan, Muhammad Hanif Baswedan Medical Faculty, Universitas Jenderal Achmad Yani Abstract Immediate memory takes place in a few seconds to minutes, but is very useful in daily activities. An information before being stored into long-term memory must be stored as immediate memory. Flavonoids can improve memory because it can increase blood flow in the brain, increase neurotransmitter activity, and in increasing compatibility can counteract neuron damage due to oxidative stress because of its antioxidant properties. Strawberries (Fragraria x ananassa) contain many phytochemical compounds which include flavonoids. This study aims to find out and provide information about the effect of strawberries on immediate memory. The research method was comparative quasi-experimental, with a pretest and posttest design. The samples taken were 30 people who were students of the Faculty of Medicine, University of Jenderal Achmad Yani. Sampling in this study uses Simple Random Sampling. Immediate memory measured using a nonsense syllable test performed before and after consuming strawberries. Statistical analysis was performed using the Dependent t test with &#945- = 0.05. The results showed that the average score after consuming strawberries was 8,776. This result is higher than the average score before consuming strawberries which is 7,000. There is an increase in the average score of 1.776 (25,22%). The results of p values showed a significant difference (p<0.05) between immediate memory before and after consuming strawberries. Based on this, it can be concluded that consuming strawberries can improve immediate memory. Keywords: Immediate Memory, Nonsense Syllable Test, Strawberries Share Link | Plain Format | Corresponding Author (Daswara Djajasasmita)

25	Biomedical Science	ABS-75
The Characteristics and Lipid Profile Levels in Vegetarian and Non-Vegetarian Subjects - What^s the Difference? Muhammad Hanif Baswedan, Rini Roslaeni, Budhi Suwarma Medical Faculty, Universitas Jenderal Achmad Yani Abstract Coronary Heart Disease (CHD) and stroke are two diseases that have high incidence rates, especially in Indonesia. One of the causes is the formation of atherosclerotic plaque in which can be characterized by an abnormal lipid profile. Lipid profile can be influenced by several factors, which are age, sex, physical activity, smoking, and especially dietary habit. A bad dietary habit: such as consuming a high fat in which can influence the blood lipid profile. The purpose of this study was to determine the characteristics and lipid profile levels in vegetarian and non-vegetarian subjects Advent Indonesia University. The method of this study was descriptive observational with a cross-sectional design. The sample size of this study was 19 students of vegetarian and 19 students of non-vegetarian with 95% of CI. The subject was chosen by the simple random sampling method. The parameters of lipid profile which were checked in this study i.e., total cholesterol, HDL, LDL, and triglyceride. Examination of lipid profile levels was done in the Clinical Pathology Laboratory of Jenderal Achmad Yani University. The study showed that mean levels of total cholesterol in group vegetarian was 155,78 mg/dL, HDL was 52,85 mg/dL, LDL was 90,22 mg/dL, and triglyceride was 69,80 mg/dL. Based on the results of this study, it can be concluded that vegetarian and non-vegetarian subject had a normal mean level of lipid profile. Further research is needed with another design (case-control), a bigger population used, and with a different way of analysis. Keywords: dietary habit, lipid profile, vegetarian Share Link | Plain Format | Corresponding Author (Muhammad Hanif Baswedan)

26	Biomedical Science	ABS-78
The Effectiveness of Flavonoids From The Ethanol Extract of Daun Dewa (Gynura Divarycata L) to Increase The Number of Pancreatic Beta Cells in The Pancreatic Gland Through Histopathological Observations Dian Anggraeny, Mutia Susparini Subando, Ris Kristiana, Raynisa Budhy Pratiwi Jenderal Achmad Yani University Abstract Diabetes mellitus (DM) is a metabolic disease characterized by increased blood glucose levels. The condition of hyperglycemia that occurs continuously can increase oxidative stress, resulting damage to the pancreatic beta cells. Glibenclamide treatment often used in the treatment of diabetes mellitus. However, glibenclamide cannot stimulate an increase in the number of pancreatic beta cells if its damage. Nowadays many traditional treatments are searched to treat pancreatic beta cell damage. One of them uses ethanol extract of DaunDewa which has antioxidant and hypoglycemia effects. This study aims to prove that the administration of ethanol extract of DaunDewa can have an effect on decreasing blood glucose levels and increase the number of pancreatic beta cells in people with diabetes mellitus. This research is an experimental study with a post test only control group design. The research subjects used were 24 DDY mice divided into four groups consisting of negative control (K1), positive control (K2) (alloxan 150mg/kgBB), ethanol extract of DaunDewa(K3) (400mg/kgBB), Glibenclamide (K4) (0.64mg/kgBB). Data were analyzed using the Post HocTukeytest to see meaningful differences between groups. The results showed significant differences (p,0.05) between the group ofethanol extractof the DaunDewa with thepositive group (p value=0.000) and significant differences between theethanol extractof DaunDewagroupand the glibenclamide group (p value=0.001). But there was no significant difference (p>0.05) between the group of ethanol extract of the DaunDewa with thenegative group (value p=0.991). Significant differences show that ethanol extract can reduce blood glucose levels by increasing the number of pancreatic beta cells that have been induced by alloxan. The active component of flavonoids in the ethanol extract of DaunDewa acts as an antioxidant has been effective in increasing the number of pancreatic beta cells. Keywords: Diabetes Melitus, Ethanol extract of DaunDewa, Pancreaticbeta cells Share Link | Plain Format | Corresponding Author (Raynisa Budhy Pratiwi)

27	Biomedical Science	ABS-80
Gambaran Histopatologi Hepar Mencit Galur DDY Pada Uji Toksisitas Akut Ekstrak Etanol Daun Salam Ris Kristiana, Maman Djamaluddin, Astri Pradini, Milani Indah K, Bagus Yuda Permana Fakultas Kedokteran Universitas Jenderal Achmad Yani Abstract Daun salam (Syzygium polyanthum (Wight) Walp) merupakan salah satu tanaman yang digunakan sebagai obat herbal di Indonesia. Senyawa aktif dalam daun bermanfat sebagai antibakteri, antidiare, antihiperglikemik, antihiperlipidemia, antihiperuresemia, antioksidan, dan antiinflamasi. Obat merupakan zat asing yang dapat berpotensi menyebabkan hepatotoksisitas. Penelitian sebelumnya menyimpulkan bahwa ekstrak etanol daun salam (EEDS) termasuk kategori praktis tidak toksik, tetapi belum ada keterangan pengaruhnya terhadap struktur mikroskopis organ hepar. Tujuan penelitian adalah untuk mengetahui adanya perubahan histopatologi hepar mencit yang terjadi pada kelompok pemberian akut EEDS dosis bertingkat. Perubahan histopatologi dapat berupa peradangan, degenerasi, dan nekrosis. Penelitian ini merupakan studi observasional dengan cara dilakukan pengamatan dan melihat pengaruh pemberian EEDS peroral yang terhadap keadaan histopatologi hepar mencit (Mus musculus) putih jantan dan betina galur DDY. Sediaan berjumlah 55 buah, terdiri dari 3 kelompok, yaitu kelompok kontrol negatif (K), kelompok diberikan EEDS dengan dosis 1250 mg/kgBB (P1), dosis 2500 mg/kgBB (P2), dan dosis 5000 mg/kgBB (P3). Setelah dilakukan terminasi, organ hepar diambil dan dilakukan penilaian morfologi secara mikroskopis. Hasil penelitian berdasarkan uji statistik penilaian perubahan hepatosit dengan sistem skoring Manja Roenigk menunjukkan terdapat perbedaan yang signifikan pada rerata skor perubahan hepatosit (p<0,05). Perbedaan signifikan pada mencit jantan K-P2 dan K-P3 (p=0,032), sedangkan pada mencitbetina K-P1, K-P2, dan K-P3 (p=0,002). Ditemukan perubahan histopatologi berupa peradangan, degenerasi parenkimatosa, degenerasi hidropik, dan nekrosis. Pemberian akut EEDS dosis bertingkat menimbulkan efek toksik berupa kerusakan hepar secara mikroskopis. Keywords: toksisitas akut, histopatologi hepar Share Link | Plain Format | Corresponding Author (Ris Kristiana)

28	Biomedical Science	ABS-84
Relationship of obesity with vital lung capacity in Medical Faculty student of Jenderal Achmad Yani University Apen Afgani, Ali Yasin, Priatna, Muhammad Adam Zulqarnain Medical Faculty, Universitas Jenderal Achmad Yani Abstract Obesity is a disorder or disease that is characterized by abnormal accumulation of fat or excessive in adipose tissue which can interfere their health. In people with obesity there are fat deposits in the thoracic cavity and stomach dicrease of causing process respiratory disorder, therefore it tends to occur on obesity pulmonary capacity which would result in a decrease in lung function. The purpose of this research was know the relationship of obesity with vital lung capacity. The subject of research were the obese Medical Faculty student of Jenderal Achmad Yani University from batch 2015 until batch 2018. The sample was obtained by as many as 31 people whom obtained using simple random sampling. This research method used correlative analytic observational study with cross-sectional. Data analysis using SPSS program to test the Spearman Correlation Test. Results of the research showed a relationship between Lung vital capacity with obesity in students of the Faculty of Medicine of the University of Jenderal Achmad Yani (p < 0.05). The higher of the body mass index values causes vital lung capacity decreased. Keywords: obesity, lung vital capacity Share Link | Plain Format | Corresponding Author (Apen Afgani)

29	Biomedical Science	ABS-87
Correlation between Obesity and the Depth of Lumbar Lordosis in Obesity-typed Women in Internal Medicine Clinic Dustira Military Hospital Cimahi Wendra, Laila Azra Pratesya, Dian Mardianti Medical Faculty, Universitas Jenderal Achmad Yani Abstract Obesity is one of the most concerned health problem in Indonesia. According to Riskesdas 2013, the prevalence of obesity in Indonesia is greater in women and in the age group of 50-54 years old. Obesity is one of the risk factor of various disease, one of them is lumbar lordosis because of the change in the a person^s center of gravity. Lumbar lordosis is also one of the predisposing factors of low back pain. According to this situation, this research is focusing on correlation between the depth of lumbar lordosis and obesity-typed women in Internal Medicine Clinic, Dustira Military Hospital Cimahi. This studies is cross-sectional analytical correlation, with the size sample is 40 women of 40-50 years old with the BMI category is obesity. This sample is taken using consecutive sampling. Data was analyzed descriptively and statistically by using Spearman correlation. Result shows that there is a significant correlation between the depth of lumbar lordosis and obesity (r=0,843, p=<0,001). Keywords: Depth of Lumbar Lordosis, Lumbar lordosis, Obesity Share Link | Plain Format | Corresponding Author (Laila Azra Pratesya)

30	Biomedical Science	ABS-96
Characteristic of SGOT and SGPT Elevation in patient with lung tuberculosis within therapy in RS Dustira I Wayan Agus Putra (a), Khairana Lonovi (a), Lina Damayanti (a), Trisnu Kamajaya (b) (a) Medical Faculty, Universitas Jenderal Achmad Yani Jalan Terusan Jend. Sudirman, Cibeber, Kec. Cimahi Sel., Kota Cimahi, Jawa Barat 40531 (b) Medical Faculty, Universitas Udayana Kampus Bukit, Jl. Raya Kampus Unud Jimbaran, Kec. Kuta Sel., Kabupaten Badung, Bali 80361 Abstract Lung Tuberculosis (TB) is still a disease-causing severe health problem globally, including Indonesia, based on morbidity yet mortality perspectives. Tuberculosis therapy having a side effect from its hepatotoxicity, causing hepatitis-caused anti-tuberculosis drugs (OAT). Many factors were to influence the incidence of age, gender, nutritional status, length of therapy, etc. This research was conducted to understand the characteristic of elevation of SGOT and SGPT in newly treated tuberculosis with OAT in RS Dustira from January to December 2016. This research design is descriptive, with a total sample of 99 patients. Based on the research, 26 patients were elevated (26,3%) and 73 patients with a regular limit value of SGOT and SPOT (73.7%). This research showed the 18 patient with 1st degree of hepatitis-caused OAT (69.2%), 2nd degree of hepatitis-caused OAT in 5 patients (19.3%), and 3rd degree of hepatitis-caused OAT. Overall, patient with TB in RS Dustira was to have an elevation of SGOT and SGPT were to be found within 40-49 year age of a group (34.5%), women (57,7%), underweight nutritional status (53.8%), and length of medication of 2 weeks (26,9%). In conclusion, most patients with newly diagnosed TB were to see an elevated SGOT and SGPT value after therapy. Keywords: Tuberculosis, Hetatitis-caused OAT, OAT, SGOT, SGPT Share Link | Plain Format | Corresponding Author (I Gusti Ngurah Agung Trisnu Kamajaya)

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