Characteristic of SGOT and SGPT Elevation in patient with lung tuberculosis within therapy in RS Dustira
I Wayan Agus Putra (a), Khairana Lonovi (a), Lina Damayanti (a), Trisnu Kamajaya (b)

(a) Medical Faculty, Universitas Jenderal Achmad Yani
Jalan Terusan Jend. Sudirman, Cibeber, Kec. Cimahi Sel., Kota Cimahi, Jawa Barat 40531
(b) Medical Faculty, Universitas Udayana
Kampus Bukit, Jl. Raya Kampus Unud Jimbaran, Kec. Kuta Sel., Kabupaten Badung, Bali 80361

Abstract

Lung Tuberculosis (TB) is still a disease-causing severe health problem globally, including Indonesia, based on morbidity yet mortality perspectives. Tuberculosis therapy having a side effect from its hepatotoxicity, causing hepatitis-caused anti-tuberculosis drugs (OAT). Many factors were to influence the incidence of age, gender, nutritional status, length of therapy, etc. This research was conducted to understand the characteristic of elevation of SGOT and SGPT in newly treated tuberculosis with OAT in RS Dustira from January to December 2016. This research design is descriptive, with a total sample of 99 patients. Based on the research, 26 patients were elevated (26,3%) and 73 patients with a regular limit value of SGOT and SPOT (73.7%). This research showed the 18 patient with 1st degree of hepatitis-caused OAT (69.2%), 2nd degree of hepatitis-caused OAT in 5 patients (19.3%), and 3rd degree of hepatitis-caused OAT. Overall, patient with TB in RS Dustira was to have an elevation of SGOT and SGPT were to be found within 40-49 year age of a group (34.5%), women (57,7%), underweight nutritional status (53.8%), and length of medication of 2 weeks (26,9%). In conclusion, most patients with newly diagnosed TB were to see an elevated SGOT and SGPT value after therapy.

Keywords: Tuberculosis, Hetatitis-caused OAT, OAT, SGOT, SGPT

Topic: Biomedical Science