FLAVONOID-RUTIN EFFECT TO BLOOD GLUCOSE LEVEL AND PANCREAS REGENERATION IN DIABETIC RATS IIS INAYATI RAKHMAT, EUIS RENI YUSLIANTI, TEJA KOSWARA
Faculty of medicine, Universitas Jenderal Achmad Yani Cimahi
Abstract
Diabetes mellitus is chronic metabolic disorder characterized by hyperglycemic state triggers by the formation of cells free radical. Rutin as a flavonoid or secondary antioxidant can increase insulin secretion and stimulate pancreatic progenitor cells. This study aims to analyze the effect of flavonoid-rutin to decrease blood glucose levels and pancreas regeneration in diabetic rats induced by streptozotocin. Research model was a laboratory experimental and total sample 25 experimental animals consisting of 5 groups those are negative control (NC), positive control (PC), Flavonoid-flavonoid-rutin 25mg/kgBW (P1), Flavonoid-rutin 50mg/kgBW (P2), and Flavonoid-rutin 100mg/kgBW (P3). The study was conducted for 17 days by examination of blood glucose levels and pancreas regeneration. Data were analyzed Anova and Duncan (P<0,05). The results showed flavonoid-rutin 50 mg/kgBW can reduce blood glucose levels and regenerate the pancreas because has the ability to reduce free radicals that increase in conditions of hyperglycemia.
