Page 9 (data 241 to 270 of 382) | Displayed ini 30 data/page
<< PREV 1 2 3 4 5 6 7 8 9 10 11 12 13 NEXT >>

241	Medicine and Health Sciences	ABS-325
Cianjur Earthquake Disaster Emergency Management: MDMC Sitrep Study Margono Muhamamdiyah Magelang Univercity Abstract Indonesia is a country prone to disasters. Entering the end of 2022, in the Cianjur area, West Java, on November 21, 2022, 17,864 houses were recorded as heavily damaged, 321 people died, 11 people were missing, 108 were injured and 73,874 people were displaced. So the emergency response period is set at 1 month. Muhammadiyah Disaster Management Center ( MDMC) has been carrying out an emergency response since the disaster occurred and providing assistance for the next 3 months. The purpose of this study was to find out the emergency response handlers carried out by Muhammadiyah. The methodology in this research is to analyze the sitrep report documents made by MDMC. The condition of the people in Cianjur are currently displaced in scattered locations because they are still prone to landslides. So the urgent need is temporary housing. Muhammadiyah^s response in the emergency response was carrying out treatment, forming a public kitchen, psychosocial, logistical assistance, and deploying a Muhammadiyah SAR team. So that Muhammadiyah has provided assistance to 18,185 beneficiary souls. Implementation in this study states that Sitrep is needed in implementing, evaluating and also future improvements in disaster management Keywords: Cianjur, management, disaster, situation report, MDMC Share Link | Plain Format | Corresponding Author (Margono Margono)

242	Medicine and Health Sciences	ABS-72
The Effect of Acupressure on Length of Labour: A Literature Review Aziza Vira Arunita1*, Heni Setyowati Esti Rahayu2, Kartika Wijayanti3 1Bachelor of Nursing Study Program, Faculty of Health Sciences, Muhammadiyah University of Magelang 2Faculty of Health Sciences, Muhammadiyah University of Magelang 3Faculty of Health Sciences, Muhammadiyah University of Magelang Abstract Background: Prolonged labor is labor that lasts more than 24 hours for primiparas and more than 18 hours for multiparas. Long labor can occur either directly or indirectly. Prolonged labor can cause infection, fatigue, dehydration in the mother, and can cause postpartum hemorrhage which can cause maternal death. One way to prevent long labor nonpharmacologically is acupressure. Purpose: Conduct a literature review on the effect of acupressure on length of labour. Methods: The method used in this study was a literature review design by taking secondary data from Google Scholar using the keyword ^the effect of acupressure on length of labor^, as many as 5 articles that met the inclusion criteria with the publication year range 2017 -2022. Results: There was an effect of acupressure on the length of labor with an average length of labor in the latent phase I stage 5 hours 6 minutes (< 6 hours) and an average length of labor in the active phase I stage 5 hours 4 minutes (< 6 hours). There was an increase in maternal contractions in the active phase I of labor with an average uterine contraction frequency of 4.5952 (5 times in 10 minutes) with a contraction score of at least 4 times in 10 minutes and a maximum of 5 times in 10 minutes. 10 minutes. The LI4, SP6, BL67, BL311, BL32, and GB21 points can be used to speed up the duration of labor by pressing 15x in 15 minutes clockwise. Conclusion: Acupressure is proven to accelerate labor in the first stage of labor as evidenced by 5 articles showing a p value = <0.05. Keywords: Acupressure- Duration of Labour- First Stage of Labour Share Link | Plain Format | Corresponding Author (Aziza Vira Arunita)

243	Medicine and Health Sciences	ABS-333
Correlation between side effects of the extrapyramidal syndrome and quality of life in the outpatient unit of a hospital in Purworejo, Central Java Ayu Nissa Ainni, Fita Rahmawati Pharmacy Study Program, Fakulty of Health Sciences, Gombong Muhammadiyah University, Kebumen, Central Java Division of Pharmacology and Pharmacy Clinics, Muhammadiyah University, Surakarta Indonesia Faculty of Pharmacy, Universitas Gadjah Mada Abstract Residual schizophrenia is a chronic condition of schizophrenia in which there is at least one clear psychotic episode and the symptoms are negative. First and second-generation antipsychotics are the therapy given, but the administration of antipsychotic drugs often causes side effects in the form of extrapyramidal syndrome which causes interruption of treatment and can worsen the patient^s condition and affect the quality of life. The purpose of this study was to analyze the relationship between extrapyramidal side effects and quality of life in outpatient residual schizophrenia at a hospital in Purworejo, Central Java. This study used a cross-sectional research design with prospective data collection. Intake for extrapyramidal syndrome side effects using the Naranjo Scale, while for the quality of life using the EQ-5D questionnaire. Data were analyzed using the Chi-Square or Fisher^s Exact test with a significant p-value &#8804- 0.05 using the SPSS version 16.0 program. There is a significant effect of the incidence of ADRs with extrapyramidal syndrome symptoms on the quality of life of residual schizophrenia patients with a p-value <0.05. This research is useful for pharmacies in minimizing the risk of extrapyramidal syndrome side effects to improve the quality of residual schizophrenia patients Keywords: Antipsychotics- extrapyramidal syndrome- quality of life- residual schizophrenia Share Link | Plain Format | Corresponding Author (Ayu Nissa Ainni)

244	Medicine and Health Sciences	ABS-337
Preparation And Evaluation Of Microemulsion Containing Clove Oil Naelaz Zukhruf Wakhidatul Kiromah(a)*, Nining Sugihartini(b), Laela Hayu Nurani(c) (a)Pharmacy, Faculty of Health Sciences, Universitas Muhammadiyah Gombong, Yos Sudarso Street 461, Kebumen, Jawa Tengah, Indonesia (b,c)Faculty of Pharmacy, Universitas Ahmad Dahlan, Yogyakarta, Indonesia Abstract Clove oil (MABC) is one type of essential oil from clove flower buds have volatile properties at room temperature, unstable, very little solubility and cannot be mixed with water. Therefore, clove essential oil needs to be made in the form of a microemulsion. This study aims to formulate and characterize microemulsion preparations with clove flower essential oil as the active substance. This research begins with the analysis of compounds using GC MS and then to make a microemulsion base consisting of tween 80, PEG 400, isopropyl myristate, and aquadest using a pseduoternary diagram. The obtained microemulsion base was then added with 10% clove oil. Based on the results of the study, it was shown that the highest component of the compound in MABC was eugenol. The microemulsion base was the most optimum 1:9. The evaluation results showed that was stable during 30 days of storage both pH value and %transmittance and the base also showed viscosity, globule size, zeta potential that met the characteristics of microemulsion preparations. The MABC microemulsion was then formulated and showed that the evaluation results had a globule size of 17.69nm, a polydispersity index of 0.057, zeta potential of minus 5.36mV, a pH value of 7.3, a viscosity of 466.7 cPs, %transmittance 99.9. Keywords: microemulsion-clove flower-essential oil-stability Share Link | Plain Format | Corresponding Author (Naelaz Zukhruf Wakhidatul Kiromah)

245	Medicine and Health Sciences	ABS-351
The Effect of Indian Sandalwood Essential Oil (Santalum Album Linn) in Inhibiting The Growth of Biofilm Streptococcus Mutans ATCC 25175 Please Just Try to Submit This Sample Abstract Ciptadhi Tri Oka Binartha, Velicia Ghina Nadhifa Faculty of Dentistry, Universitas Trisakti Jl. Kyai Tapa no 260 Jakarta Barat, Indonesia Abstract One of the main causes of dental caries is Streptococcus mutans. Chlorhexidine gluconate 0.2% it is a gold standard for antibacterial mouthwash. Chlorhexidine gluconate can cause an allergic reaction and produce staining on teeth if use in the long term. Indian sandalwood essential oil is a natural substance that has an antibacterial properties with less side effects. To determine the effect of Indian sandalwood essential oil (Santalum album Linn) extract in inhibiting the growth of Streptococcus mutans ATCC 25175 biofilm. Streptococcus mutans ATCC 25175 was cultured in nutrient broth and incubated at 37 C for 24 hours. Biofilm was made by inoculating the culture to a 96 well plate. Well plate then incubated for 24 hours. Indian sandalwood essential oil with concentration of 100%, 50%, 25%, 12.5%, 6.25%, 3.125%, and 1.56% was made. Biofilm was tested by using the biofilm assay method with 15 and 30 minutes time. Chlorhexidine gluconate 0.2% was used as positive controls. The result was obtained using a microplate reader by observing the optical density values at 595 nm wavelength. Indian sandalwood essential oil with the best concentration is 1.56% because can inhibit the growth of Streptococcus mutans ATCC 25175 biofilm. ANOVA test shows that there are significant differences in each concentration groups compared to 0.2% chlorhexidine gluconate. Indian sandalwood essential oil (Santalum album Linn) can inhibit the growth of Streptococcus mutans ATCC 25175 biofilm. Keywords: Indian sandalwood essential oil (Santalum album Linn), biofilm, Streptococcus mutans, dental cariesPlease Just Try to Submit This Sample Abstract Share Link | Plain Format | Corresponding Author (Rini Setiati)

246	Medicine and Health Sciences	ABS-353
Prototype of Information System for Adverse Drug Reaction Monitoring in Hospitals Zaleha Rumadi 1, Ashichach Indraswari 1, Ikafatimah Sophieyati 1, Rian Nugraha 1, Setiyo Budi Santoso 1, Prasojo Pribadi 1, Elmiawati Lathifah 1,a Universitas Muhammadiyah Magelang Abstract Adverse Drug Reaction Monitoring (ADRM) is one of the responsibilities of pharmacists in hospitals. However, practitioners experience problems documenting monitoring results due to the limited support for digital-based information systems. Our article presents a prototype information system for pharmacists to store data on the results of ADRM activities. The prototype includes a flowchart and user interface design of the system^s operations. The preparation of flowcharts uses the draw.io application, which is confirmed by the design of the user interface developed with the Microsoft Power Point application. Our prototype shows a series of menus beginning with user login, a three-step ADRM data input process, and two steps for displaying patient data. Furthermore, the development of prototypes in the form of software applications will present a digital-based transformation of the role of pharmacists, which certainly optimizes performance in the ADRM documentation. Keywords: Pharmacist, Flowchart, User Interface Design, Digital-Based Transformation, Documentation Share Link | Plain Format | Corresponding Author (Zaleha Rumadi)

247	Medicine and Health Sciences	ABS-354
Design Of Oxygen Generator Based On Oxymetry : Prototypes for Vergenios Baby Nur Chabibah, Sandi Ari Susiatmi, Alfa Yuliana Dewi, Titis Aji Wicaksono, Mohammad Ilham Maulana Karim Priatna Faculty of Health Sciences, Pekajangan Pekalongan Muhammadiyah University Abstract 1.Introduction: Oxygen therapy saves lives in several respiratory and non-respiratory diseases in both neonates and children. The most common indication for oxygen therapy in newborns was pneumonia, which was one of the leading causes of death in children under five years old in most developing countries. The Oxygen Concentrator (OC) comes as a welcome change to this cylinder place. Oxygen concentrators save up to 25-50% in cost over cylinders in poor resource settings. This oxygen therapy is even more effective if a control system is given to regulate the oxygen needs of the client in the form of oxymetry control. 2. Purpose: Designed an oxygen concentrator with Pressure Swing Adsorption and Oxymetry Pulse Control to be used for newborns and neonates 3. Method: This study uses a research and development design. The variables tested in this study were the function of the Oxygen Generator Based On Oxymetry and the volume of oxygen produced. At this stage, the assembly and coding of the Oxygen Concentrator is carried out, consisting of a series of hardware and software for oxygen concentrator software with a Pressure Swing Adsorption (PSA) work system equipped with Arduino-based pulse oximetry control. 4. Main Finding: The results of the research at this stage are that the hardware of the Oxygen Concentrator Based On Oxymetry has been assembled and the completion of the Arduino IDE coding. Testing the Oxygen Concentrator Based On Oxymetry function works properly which is marked when the power button is in the ON position, the Pressure Swing Adsorption (PSA) unit shows the LCD screen display entering the main menu and the words ^Ready to use^ appear, and the oxygen indicator on oxymetry shows the concentration of oxygen produced. At this stage the oxygen concentration produced is an average of 36%. 5. Implication: At this stage the Oxygen Generator Based On Oxymetry is functioning but with a low oxygen concentration, so it is necessary to make improvements in the assembly design of the next prototype. Keywords: Design- Oxygen Generator- Oxymetry Share Link | Plain Format | Corresponding Author (Nur Chabibah)

248	Medicine and Health Sciences	ABS-112
Review Article: Katuk Leaf (Sauropus androgynus) and Milk Production of Breastfeeding Mothers in Indonesia Setyaningrum Rahmawaty (a*), Zelyne Avita Padmasari (a) a) Department of Nutrition Science, Faculty of Health Science, Universitas Muhammadiyah Surakarta. Jl. A. Yani Tromol Pos 1 Pabelan Kartasura, Surakarta, Central Java, Indonesia, 57102 * setyaningrum_r[at]ums.ac.id Abstract Insufficient milk production has been reported as the common reason for breastfeeding mothers in Indonesia who did not give exclusive breastmilk to their babies. Several strategies have been advised to overcome this problem, for instance by consuming plans that have been proved responsible for improving the brestmilk production, i.e., katuk leaf (Sauropus androgynus). This study explores the effectiveness of katuk leaf on breast milk production of breastfeeding mothers based on studies conducted in Indonesia. A literature review was performed on 6 studies which were selected through 2 Indonesian article search engines namely Garuda (garuda.kemdikbud.go.id) and Indonesia One Search (onesearch.id) for the period of 2016-2021 by keywords Katuk leaf, breast milk production, nursing mothers, and Sauropus androgynus. The inclusion criteria for the study selection were an experimental study in breastfeeding mothers, full text written in Indonesian or English, and articles published in journal indexed by Scopus 1-4 or by Indonesian journal indexation, Sinta 1-4. The results showed that consumption of Katuk leaf in the form of Katuk leaf extract capsules of 300 mg/d, Katuk leaf boiled water of 300 cc/d obtained from 100 mg fresh Katuk leaf, and 9 biscuits/d substituted with Katuk leaf for the duration of a minimum 7 days increase and facilitate the breast milk production of breastfeeding mothers. It was indicated by an increase in baby^s weight and the mother^s prolactin hormone content. The milk production of breastfeeding mothers who consumed the Katuk leaf was better than those who did not consume the leaf with the majority p-value of the selected studies was 0.000. Keywords: Breast milk production, katuk leaf, mothers, Sauropus androgynus. Share Link | Plain Format | Corresponding Author (Setyaningrum Rahmawaty)

249	Medicine and Health Sciences	ABS-369
STIGMA ANALYSIS OF YOUNG WOMEN WITH HIV/AIDS AT SMK NEGERI 1 CILACAP IN 2021 Dwi Maryanti, Choirur Rizqiya, Sohimah Universitas Al-Irsyad Cilacap Abstract 1. Introduction : <The high number of HIV/AIDS cases cannot be separated from the problem of stigma, especially among adolescents. Stigma is formed due to ignorance, lack of knowledge about HIV/AIDS, and misunderstandings about HIV transmission. Based on a preliminary survey of 15 female students at SMK Negeri 1 Cilacap, it was found that the majority of adolescents did not understand transmission and had incorrect prejudices about HIV/AIDS> 2. Purpose : <The purpose of this study was to determine the analysis of adolescents^s stigma about HIV/AIDS at SMK Negeri 1 Cilacap in 2021> 3. Method : <The type of research used is quantitative with cross-sectional. The population of the study was class XI students at SMK Negeri 1 Cilacap with a sample of 95 respondents. The sampling technique used Cluster Random Sampling with the data collection method using a questionnaire. The study was conducted in January 2022> 4. Main Finding : < The majority of young women had stigma against the cause of HIV/AIDS and the mode of transmission of HIV/AIDS > 5. Implication : < The results of this study may have an impact on key HIV-AIDS populations who are reluctant to check themselves, PLWHA discloses their HIV status, and are reluctant to seek treatment> 6. Keywords : <Stigma- HIV/AIDS- Young Women> Keywords: Please Just Try to Submit This Sample Abstract Share Link | Plain Format | Corresponding Author (Dwi Maryanti)

250	Medicine and Health Sciences	ABS-117
Relationship Between Random Glucose Levels and Stroke Severity Using The National Institutes of Health Stroke Scale (NIHSS) in Acut Ischemic Stroke Patiens at dr. Harjono S Ponorogo Hospital Saiful Nurhidayat (a*), Sulistyo Andarmoyo (b), Wiwik Widiyati (c), Dian Laila Purwaningroom (d) Fakultas Ilmu Kesehatan Universitas Muhammadiyah Ponorogo Abstract Increased glucose levels are a common condition found in acut stroke. Elevated glucose levels not only reflect the initial volume of infarcted brain tissue, but are also factors that determine the initial extent of infarction, functional ability, and mortality in stroke patients. The National Institutes of Health Stroke Scale (NIHSS) is one of the instruments used to measure the level of functional impairment or neurological deficits due to acute stroke. This study is an observational analytic study with a cross-sectional design to determine the relationship between random glucose levels and stroke severity using the National Institutes of Health Stroke Scale (NIHSS) in acute ischemic stroke patients at RSUD Dr. Harjono S Ponorogo. This type of research is non-experimental research. The research was conducted in the stroke patient room. Sampling uses consecutive sampling, instrument used medical records to look at respondent^s baseline data, random blood sugar results and their medical diagnosis and NIHSS to assess neurological deficits. The entire data analysis process was carried out using the SPSS 25.0 windows application program. Correlation analysis using the spearman test between random glucose levels and NIHSS values obtained the results of the analysis of p = 0,253 (>0.05), these results of showed no correlation between random glucose levels and stroke severity. Based on the results of this study, it can be concluded that there is not enough evidence that random glucose levels can be used as a good predictor for determining the clinical outcome of acute ischemic stroke patients. Other examination indicators are needed that are better in predicting the clinical outcome of ischemic stroke patients in the acute phase. Keywords: Acute ischemic stroke, random glucose levels, NIHSS Share Link | Plain Format | Corresponding Author (SAIFUL NURHIDAYAT)

251	Medicine and Health Sciences	ABS-118
Effect Of Mahabah Package To Increase Breast Milk Production In Postpartum Mothers After The Covid-19 Pandemic: A Case Study In Indonesia Maryatun(1*), Indarwati(2), Endang Sri Wahyuni (3), Fida Husain 1,2,4) Department of Nursing, Faculty of Health Sciences, Universitas Aisyiyah Surakarta, Surakarta, Indonesia *mtunmarya[at]aiska-university.ac.id 3) Department of Midwifery, Faculty of Health Sciences, Universitas Aisyiyah Surakarta, Surakarta, Indonesia Abstract Postpartum mothers in the era of Covid-19 have bigger challenges in their efforts to care for their babies. Unsuccessful adaptation as a result of postpartum anxiety has an impact on milk production. At the beginning of life, newborns need breast milk as the main food. Expenditure of breast milk that is not optimal will pose a risk to the health of newborns who need immunity to prevent infection. The purpose of this study was to increase milk production in postpartum mothers. The design of this study was a quasi-experimental design with a pre-post test design with a control group. The sampling technique was 33 postpartum mothers on the first day. The instrument for increasing breast milk production was measured using measuring cups and observation sheets. The mahabbah package instrument is designed to combine 3 methods of breast care to increase milk production, namely breast care, oxytocin massage using electric devices and education on how to breastfeed properly. The results of the intervention showed that there were differences in milk production before and after giving the Mahabah package. Milk production significantly different (p : 0.001). Breast care interventions with the Mahabah package model can significantly increase milk production. The Mahabbah package is expected to contribute to postpartum mothers, especially in areas with remote access to health services. Keywords: post partum- breast milk- mahabbah package Share Link | Plain Format | Corresponding Author (maryatun maryatun)

252	Medicine and Health Sciences	ABS-375
Thyroid Disorders as a Factor Related For Sunting: a Literature Review Septi Wardani, Dwi Sulistyono Universitas Muhammadiyah Magelang Abstract Stunting is a nutritional problem that has multifactorial causes. These multifactorial causes include poor nutritional intake, genetic factors and hormonal problems. Thyroid disorders are one of the hormonal problems that cause stunting. This literature review is to describe whether thyroid disorders are a factor associated with stunting in children The literature search used two databases, pubmed and google scholar, with the keywords stunting, thyroid disorders. The focus of the selection of articles is original research, in English and published from 2021 to 2022, with the criteria for stunting children The finding showed that from 3,500 children, 13.4% were stunted, and as many as 872 children or 25% of children had thyroid disorders, and from the results of this literature review, it was conveyed that there was a relationship between thyroid disorders and the incidence of stunting in children This study can provide benefits for the community and health workers, by jointly preventing thyroid disorders in mothers and babies, it will reduce the risk of stunting in children due to thyroid disorders. Keywords: Stunting- thyroid disorders- related factors Share Link | Plain Format | Corresponding Author (Septi Wardani)

253	Medicine and Health Sciences	ABS-379
The Effect Of Doses Of Red Shoot Leaf Extract (Syzygium myrtifolium Walp) On Decreased Cholesterol Total Levels In Male White Wistar Rats In Vivo Denih Agus Setia Permana (a), Mika Tri Kumala Swandari (b), Imam Agus Faizal (c*), Dini Puspodewi (d), Aprilia Iin Aminia Putri (e) a) D3 Pharmacy of Department, Faculty of Pharmacy, Science and Technology, Al-Irsyad Cilacap University, Indonesia b) S1 Pharmacy of Department, Faculty of Pharmacy, Science and Technology, Al-Irsyad Cilacap University, Indonesia c) Bachelor of Applied Medical Laboratory Technology Departement, Faculty of Pharmacy, Science and Technology, Al-Irsyad Cilacap University, Indonesia *imamdfaizal[at]stikesalirsyadclp.ac.id d) Bachelor of Applied Medical Laboratory Technology Departement, Faculty of Pharmacy, Science and Technology, Al-Irsyad Cilacap University, Indonesia e) S1 Pharmacy of Department, Faculty of Pharmacy, Science and Technology, Al-Irsyad Cilacap University, Indonesia Abstract The prevalence of cholesterol in Indonesia is 66.41%. Central Java is among the five provinces with the highest levels of consumption of fatty, cholesterol, and fried foods, at 60.3%. The purpose of this study was to determine the effect of an extract of red shoot leaves (Syzyginium myrtifolium Walp). on decreasing the profile value of total cholesterol levels in male Wistar strain white rats. Red sprout leaf extract was obtained using the maceration process. Red shoot leaf extract contains anthocyanin compounds that can lower cholesterol, flavonoid compounds, and tannin compounds. his research is a purely experimental design with a before-and-after test with a control group using 30 rats divided into 5 groups, negative control (rats with hypercholesterolemia and Na-CMC 0.5%), positive controls (rats with hypercholesterolemia and 10 mg simvastatin). , administration of red shoot leaf extract at extract dose 1 (200 Mg/Kg BW), extract dose 2 (250 Mg/Kg BW), and extract dose 3 (300 Mg/Kg BW). The total number of test animals used was 30 animals, each group consisted of 5 rats. The results of the ANOVA repeated measures test/Friedman test analysis showed that the activity of The Red shoot leaves (Syzyginium myrtifolium Walp) as a cholesterol-lowering agent for reducing total cholesterol levels was demonstrated with the potential efficacy in extract group 3 (300 mg/kg BW) with a significant value of 0.647. Keywords: Red sprout leaf, total cholesterol, LDL, HDL, triglycerides, Decreased, Wistar rat Share Link | Plain Format | Corresponding Author (Imam Agus Faizal)

254	Medicine and Health Sciences	ABS-390
The Ruling of Novel Drugs to The Molecular Targets on Variant Pathologicalhis Henik Setiyaningsih 1, Imron Wahyu Hidayat1, Alfian Syarifuddin1, Setiyo Budi Santoso1, Ratna Wijayatri1a 1Department of Pharmacy, Universitas Muhammadiyah Magelang, Indonesia Abstract In recent decades, the investigation of novel drugs have not only been thoroughly profiled at the molecular level but have also been employed in extensive pharmacogenomic studies. Our paper present the ruling of novel drugs to the molecular targets on variant pathological. The study involves literature indexed by Scopus, and Pubmed databases, and the search uses a combination of the following keyword variants- ^ClinicalTrials.gov AND Genomic^,^ClinicalTrials.gov AND repurposing drug^ This study only used original articles in english l which were peer reviewed journals published between 2013 and 2022. Thus, the screening results of library sources were narrowed to 15 original articles papers that met the inclusion criteria. Our review shows that the target gene for treating depression, IL6R, has one of the best functional annotation scores among the target genes. Systemic inflammation, which is linked to the emergence of depression, is regulated by IL6R. identified sarilumab and satralizumab as two other IL6R-targeting medications. To identify prospective anti-breast cancer candidate medications, researchers compared these trends across tamoxifen, raloxifene, and paclitaxel. According to what Cell Walktrap (CW), Cell label propagation (CLP), Cell leading eigenvector (CLE), and Cell Infomap (CI) anticipated, we found that these medications are quite comparable to tamoxifen. Last, the molecular pathway of CD80 and CD86 were discovered, and it explains the risk of autoimmune diseases and may be considered a possible candidate gene for multiple sclerosis, such as anti-thymocyte immunoglobulin, abatacept, and belatacept. Our findings give up new opportunities for the development of pharmacogenomic-based follow-up studies on racial variations that have not previously been studied. Keywords: repurposing drug, depression, breast cancer, multiple sclerosis Share Link | Plain Format | Corresponding Author (Henik Setiyaningsih Setiyaningsih)

255	Medicine and Health Sciences	ABS-391
The Role of Genetic Mutation on Schizophrenia: A Basic Review Prior to Pharmacogenomics Dhea Nur Hikmah1, Alfian Syarifuddin1, Setiyo Budi Santoso1, Ratna Wijayatri1, Imron Wahyu Hidayat1,a 1Department of Pharmacy, Universitas Muhammadiyah Magelang, Indonesia Abstract A bioinformatical approach used to find indications for drug repositioning to produce new treatment paradigms for schizophrenia by comparing the binding profiles of currently available clinical compounds to targets or sets of targets derived from genome-wide association studies (GWAS) or other genetic studies. Here in, we present the molecular expression of schizophrenia due to polymorphism. The study involves literatures indexed by Scopus, and the search uses a combination of the following keyword variants- ^GWAS^ AND ^genom^, ^GWAS^ AND ^repurposing drug^. This study only used original articles in english which were peer reviewed journals published during 2022. Thus, the screening results of library sources were narrowed to 5 original articles papers that met the inclusion criteria. Our review shows that the primary hub gene from this module, SCN2B, is a well-known target of zonisamide, an antiepileptic and antiparkinsonian drug. SCN2B encodes for the voltage-gated sodium channel beta-2 subunit, which interacts covalently with the pore-forming alpha subunits to regulate activity. The remaining SynGO hub genes, SYNGR1, DNM1, and CAMK2A, are involved in the synaptic vesicle cycle. The gene DNM1 encodes Dynamin 1, a GTPase involved in synaptic vesicle endocytosis. SYNGR1 encodes synaptogyrin 1, a synaptic vesicle membrane component that regulates the synaptic vesicle cycle. Our findings give up new opportunities for the development of pharmacogenomic-based follow-up studies on racial variations that have not previously been studied. Keywords: Bioinformatical, GWAS, Genome Share Link | Plain Format | Corresponding Author (Dhea Nur Hikmah)

256	Medicine and Health Sciences	ABS-392
From The Genetic Mutation to The specific Pathologies: A Summary for The Future Perspective on Pharmacogenomic Salsabila Salma Zahrah1, Ratna Wijayatri1, Imron Wahyu Hidayat1, Alfian Syarifuddin1, Setiyo Budi Santoso1,a 1Department of Pharmacy, Universitas Muhammadiyah Magelang, Indonesia Abstract Translational bioinformatics has been new science that uses to transform huge volumes of molecular targets into therapeutic therapies. Bioinformatical approach pinpoint a better understanding of disease processes by combining genetic, phenomic, and environmental data. Our summary integrate several explanations from diverse research were combined to construct pathways that depict the expression of gene mutations in driving a variety of diseases. The study involves literatures indexed by Scopus and Pub Med, the search uses a combination of the following keyword variants- ^HaploReg^ AND ^genomic^, ^HaploReg^ AND ^repurposing drug^. This study only used original articles in english which were peer reviewed journals published during 2022. Thus, the screening results of library sources were narrowed to 12 original articles papers that met the inclusion criteria. Our review shows that atopic dermatitis due to polimorphism on locus CD07 and mutations in the null filaggrin gene in the type 2 T helper lymphocyte (Th2) signaling pathway. The mechanism of colorectal cancer was found on the miR-143/145 cluster to modulate KRAS signaling. Last the risk of gastric cancer due to rs12904 single nuceotide related to AG/GG genotype. Our findings give up new opportunities for the development of pharmacogenomic-based follow-up studies on racial variations that have not previously been studied. Keywords: Bioinformatics, Repurposing Drug, Gene Mutation Share Link | Plain Format | Corresponding Author (Salsabila Salma Zahrah)

257	Medicine and Health Sciences	ABS-393
From The Drugbank Application To The Novel Drugs: A Pharmacogenomic Summary Setya Rini Abiyana1, Setiyo Budi Santoso1, Imron Wahyu Hidayat1, Ratna Wijayatri1, Alfian Syarifuddin1, 1Department of Pharmacy, Universitas Muhammadiyah Magelang, Indonesia Abstract Due to reduced risks, time, cost, and resource requirements compared to conventional experimental procedures, computational drug development has gained relevance in recent decades. The DrugBank application has expanded the number and quality of pharmacological activity and drug metabolic pathways depicted visually. Our review elaborated a number of novel drugs and the molecular target mechanisms discovered with DrugBank. The study involves literatures indexed by Scopus and Pub Med, the search uses a combination of the following keyword variants- ^Drugbank AND Repurposing Drug^, ^Drugbank AND Pharmacogenomic^. This study only used original articles in english which were peer reviewed journals published from October 2020 to November 2022. Thus, the screening results of library sources were narrowed to 9 original articles papers that met the inclusion criteria. Our result highlighted the involvement of twenty-three drug-targeting molecules in nine spesific diseases. We discovered that the molecules listed below have been found to be key targets of therapeutic activity in cancer patients, including ACK 1, HMGA 1, PSAT 1, ESR1,UQCRH, GSTM3, FGFR2, PGD, NR1H3. On the other side, IL6R has been linked to asthma and depression, while the depression treatment has also been linked to Angiotensin II, AT1R, and AT2R interventions. Last, JAK 1, IL13, IL4, IL6R, and IL1B were the primary targets of ruling drugs on atopic dermatitis, whereas CD 80 DNA, and CD 86 were the main target in the drug discovery of multiple sclerosis therapies. Our pathway offers new perspectives on the research of discovering novel drugs and reliable foundation for advanced explanation on clinical investigations. Keywords: Molecular, Drug-targeting, DrugBank Share Link | Plain Format | Corresponding Author (Setya Rini Abiyana)

258	Medicine and Health Sciences	ABS-150
The Effect of Al-Qur^an Murottal Therapy on Anxiety in Pregnant Women: Study Literature Reviews Nia Afifatul Ulya, Heni Setyowati ER, Dwi Sulistyono Muhammadiyah University of Magelang Abstract Background: Third trimester pregnant women usually experience anxiety because labor is approaching. Anxiety is a vague and pervasive worry related to feelings of uncertainty and helplessness. Anxiety for pregnant women is dangerous because it can cause complications and even death. One of the therapies that is often used to overcome the anxiety of pregnant women is Al-Qur^an murottal therapy. Purpose: To identify the effect of murottal Al-Qur^an therapy on anxiety in pregnant women. Methods: The research method uses a literature review design by taking secondary data from Google Scholar using the Boolean operator (AND, OR) and a search strategy with PICOS found 4 articles that match the inclusion criteria. Results: Based on the 4 reviewed articles, it was found that the average level of anxiety before the intervention was given was at a mild level of anxiety and after the intervention it became not anxious. Characteristics of domicile are age not at risk, secondary education, and primipara. The surahs used are surah Maryam and Ar-Rahman with times of 14 and 17 days. Conclusion: Murottal Al-Qur^an can reduce anxiety in third trimester pregnant women. Keywords: Third Trimester, Al-Qur^an Murottal Therapy, Anxiety Share Link | Plain Format | Corresponding Author (Nia Afifatul Ulya)

259	Medicine and Health Sciences	ABS-152
The effectiveness of the Home Rehabilitation Program (HRP) after the application of Transcranial Magnetic Stimulation (TMS) post-stroke Umi Budi, Rahayu1*, Sakinah, Sakinah1, Santri Ramida2 1Department of Physiotherapy, Faculty of Health Science, Universitas Muhammadiyah Surakarta, Indonesia 2Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada Yogyakarta, Indonesia Abstract Introduction and Objective: Transcranial Magnetic Stimulation (TMS) for post-stroke patients has been shown to improve motor function in a short period, but no one has yet investigated how post-stroke rehabilitation will provide an optimal effect after additional patient Home Rehabilitation Programs (HRP) is applied. The objective of this study was to determine the efficacy of an additional HRP following TMS application in influencing plasticity and upper motor function post-stroke. Methodology: RCT^s study involved 10 post-ischemic stroke divided into two groups, 5 as a treatment group who received an HRP after TMS 1 Hz and 5 as a control group who received only TMS 1 Hz. Investigate plasticity using BDNF human marker and upper motor function using the Action Research Arm Test (ARAT) and the Wolf Motor Function Test (WMFT) before and after the program was run for 7 days in a row. Results: An independent t-test result showed that there was a significant difference in the effect of upper motor function (ARAT and WMFT) between the treatment compared to the control group with a p-value < 0.05. Increased levels average of BDNF also occurred in the treatment group. Discussion: The combination of HRP after the TMS indicates a plasticity process that was in line with improved finger motor skills and hand motor function. A strong correlation between increased levels of BDNF with ARAT and WMFT. Conclusion: A HRP after TMS 1 Hz application was more effective in improving the level of BDNF and motor function post-ischemic stroke. Keywords: Upper Motor Function, Transcranial Magnetic Stimulation, Home Rehabilitation Program, Post-ischemic stroke Share Link | Plain Format | Corresponding Author (Umi Budi Rahayu)

260	Medicine and Health Sciences	ABS-410
Fasting plasma glucose levels are associated with clinical improvement of diabetic foot ulcers Fahrun Nur Rosyid1, Muhtadi2, Andi Suhendi3, Ahmad Fadhlur Rahman4 1Department of Medical Surgical Nursing, School of Nursing, Muhammadiyah University Surakarta, Surakarta, Indonesia, 2Professor, Faculty of Pharmacy, Muhammadiyah University Surakarta, Surakarta, Indonesia, 3Faculty of Pharmacy, Muhammadiyah University Surakarta, Surakarta, Indonesia, 4School of Nursing, Muhammadiyah University Surakarta, Surakarta, Indonesia. Abstract 1. Introduction : Diabetes mellitus is a metabolic disease, which is characterized by hyperglycemia. Hyperglycemia can hinder clinical improvement of diabetic foot ulcers (DFU). 2. purpose : This study aims to assess fasting blood glucose (GDP) levels and their association with DFU clinical improvement. 3. method : This study used a clinically based cross-sectional study. Data on GDP levels and clinical improvement of diabetic ulcers were collected. Data were analyzed using the Chi square test with a significance limit of p <0.05. 4. Play Finding : GDP levels are significantly associated with clinical improvement of diabetic ulcers 5. Implications : This research can help patients understand the importance of controlling GDP for diabetic ulcer repair Keywords: Diabetes Mellitus, Fasting Plasma Glucose Levels, Clinical Improvement of Diabetic Foot Ulcer. Share Link | Plain Format | Corresponding Author (Fahrun Nur Rosyid)

261	Medicine and Health Sciences	ABS-411
Husband and family support for breastfeeding mothers with COVID-19: The Mother^s Perspective Nur Intan Kusuma, Rini Kristiyanti, Milatun Khanifah Universitas Muhammadiyah Pekajangan Pekalongan Abstract Providing breastfeeding support for mothers during the COVID-19 pandemic is an effort to achieve the success of breastfeeding. WHO recommends that mothers with COVID-19 continue to breastfeed their babies according to the mother^s condition and ability to breastfeed. The COVID-19 pandemic has impacted the delivery of health services including breastfeeding services. Husband and family support is an important factor for mothers with COVID-19 to continue to provide breast milk to their babies. This study aimed to explore the experiences of breastfeeding mothers with COVID-19 regarding the support that they received from their husband and family. Qualitative research method with a phenomenological approach was used in this study. The study involved 11 participants in the Pekalongan Regency. Participants were selected based on purposive sampling with the criteria of having a history of COVID-19 within the time span of breastfeeding. Data collection was carried out by interviews and recorded by audio recorder. The results of the interviews were carried out in transcripts and then analyzed with thematic analysis. The results showed two theme namely social suppot from husband and family and continuation of breastfeeding process. Providing support to mothers with COVID-19 by husbands and families is one of the factors that can strengthen mothers to continue breastfeeding. Keywords: Breastfeeding, breastfeeding mothers, COVID-19 Share Link | Plain Format | Corresponding Author (Nur Intan Kusuma)

262	Medicine and Health Sciences	ABS-414
Bibliometric analysis of global research on Technology Information in antimicrobial stewardship using Scopus database Heni Lutfiyati (a,b), Nanang Munif Yasin (c), Jarir At Thobari (d,e), Zullies Ikawati (a,c*), Prasojo Pribadi(b) a).Doctoral Program in Pharmaceutical Sciences, Faculty of Pharmacy, Universitas Gadjah Mada, Yogyakarta, Indonesia. b).Department of Pharmacy, Faculty of Health Science, Universitas Muhammadiyah Magelang, Magelang, Indonesia. c).Department of Pharmacology and Clinical Pharmacy, Faculty of Pharmacy, Universitas Gadjah Mada, Yogyakarta, Indonesia. d).Department of Pharmacology and Therapy, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada, Yogyakarta, Indonesia. e.Clinical Epidemiology and Biostatistics Unit, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada, Yogyakarta, Indonesia Abstract Antibiotic resistance is a global public health threat. Most countries carry out strategies to overcome the increase in antimicrobial resistance,with ^Antimicrobial Stewardship Program^. Since the late 1980s, technological tools have changed the way humans interact in their environment. Information technology is widely used in the health sector The main objective of this study is to determine publication trends focused on the use of information technology in antimicrobial stewardship for the last 10 years The method used is bibliometric analysis using VOSviewer version 1.6.18 and R-Studio. The study was conducted in October 2022 by searching through the Scopus database in 2013-2022. The result showed that there were 48 published documents from 2013 to 2022 that conducted studies on the use of information technology in the antimicrobial stewardship according to inclusion criteria (focus on developing or using applications and studies conducted in health care settings). The number of publications has increased related to the theme of the use of information technology in antimicrobial stewardship. The United states is the country that contributes the most research related to the use of information technology in antimicrobial stewardship. The presented bibliometric analysis provides relevant information about the themes of the main use of information technology in the antimicrobial stewardship. All these findings are discussed in the manuscript and conclusions are drawn. This study is useful in the health sector, namely the development of information technology in the antimicrobial stewardship Keywords: Technology information- antimicrobial stewardship, bibliometric analysis Share Link | Plain Format | Corresponding Author (Heni Lutfiyati)

263	Medicine and Health Sciences	ABS-417
THE EFFECTIVENESS OF A COMBINATION of Piper betle L. AND MANUKA HONEY EXTRACT GEL SPRAY TO ACCELERATING ACUTE WOUND HEALING Ratna Wijayatri, Eka Sakti Wahyuningtyas, Alfian Syarifuddin Universitas Muhammadiyah Magelang Abstract Background: Acute wounds are tissue injuries that are at risk of infection, therefore acute wound care must be considered carefully. Piper betle leaf contains flavonoids that play a role in the wound healing process, Manuka honey also contains vitamins that can support the phase of wound healing. The combination of Piper betle L. and manuka honey is made into a spray gel preparation because it has advantages over other topical preparations. Objective: This study aims to test the effectiveness of wound healing spray gel combination of Piper betle L. and Manuka honey on the acute wound of mice. Methods: This study uses experimental research with a randomized matched post-test only control group design. Results: The formulation taken were maceration extraction from Piper betle L. Simplicia powder with 70% ethanol then evaporated to obtain a thick extract. Spray gel preparations of a combination of Piper betle L extract and manuka honey were made with a concentration of 1% Piper betle L and Manuka honey, 3% Piper betle L and Manuka honey, and 5% Piper betle L and Manuka honey. Balb/c mice that had full-thickness acute wounds were divided into 7 treatment groups, namely SM1, SM2, SM3, M, KP, B, D. Mice were treated for 14 days and the wound area ratio was calculated and analyzed by ANOVA. The test results showed a significant difference between groups SM3-M, SM5-M, M-SM3, M-SM5, KP-M, B-SM3, BM with a significance value below 0.05 which proves that the spray gel combination of Piper betle L extract and manuka honey, manuka honey, oxoferin, and base both have activity in accelerating acute wound healing. Keywords: Piper betle, Manuka honey, Spray Gel, Staphylococcus aureus, Candida albicans. Share Link | Plain Format | Corresponding Author (Ratna Wijayatri)

264	Medicine and Health Sciences	ABS-167
The Use of Memba Leafe (Azadirachta Indica) for Recovery of Mouse Pancreas Due to Type 2 Diabetes Mellitus Mirah Rejeki, Hartono, Adi Prayitno, Soetrisno, Kun Harismah, Andi Suhendi 1 Faculty of Medicine, Universitas Sebelas Maret, Surakarta, Indonesia 2 Faculty of Medicine, Universitas Sebelas Maret, Surakarta, Indonesia 3 Faculty of Medicine, Universitas Sebelas Maret, Surakarta, Indonesia 4 Faculty of Medicine, Universiti Sebelas Maret Surakarta, Surakarta, Indonesia 5 Faculty of Chemical Eng., Universitas Muhammadiyah Surakarta, Surakarta, Indonesia 6 Faculty of Pharmacy, Universitas Muhammadiyah Surakarta, Surakarta, Indonesia Abstract . One of the serious diseases that has been a concern in medicine is Diabetes Mellitus. The rate of morbidity and mortality is significantly high. The medicine that comprehensively recovers the disease is necessary. This enables beta pancreas recovery. The extract of meemba leaf is expected to fulfill this requirement. To analyze and prove the impact of meemba leaf extract on instantaneous blood glucose level of Mouse with type 2 Diabetes Mellitus. This research uses testing animal, modified suffering for type 2 Diabetes Mellitus. Meemba leaf extract is given and the effect is observed until the blood glucose level reaches normal condition. The animal testing has been successfully modified suffering for type 2 Diabetes Mellitus. The intervention of giving the extract of meemba leaf of 250 mg/BW has demonstrated gradual improvement of the disease indicated by reduction of blood glucose level. After 28 days the disease has been completely recovered. This research findings are expected to contribute the essential treatment of the disease by recovery of pancreas cells. The extract of meemba leaf has shown the ability to do so. This material is extensively available, affordable with low price and, therefore, this will help people to recover from DM. Keywords: Diabetes Mellitus, beta pancreas cell, hyperglycemia- meemba leaf extract- blood glucose level Share Link | Plain Format | Corresponding Author (Mirah Rejeki)

265	Medicine and Health Sciences	ABS-423
The Effectiveness of Dasa Wisma Empowerment on Stunting Prevention Behavior with the Approach of Inter Professional Collaboration in Puskesmas Karanganom Klaten Sri Mulyanti (a*), Athanasia Budi Astuti (b) Nursing Department of Surakarta Health Polytechnic Indonesia Abstract Stunting is still a health problem for infants and children in Indonesia. The 2018 Basic Health Research (Riskesdas) results show that the incidence of stunting still reaches 29.9% and ranks in the top 10 worldwide. One of the districts with a fairly high stunting rate is Klaten. Aim of this study is knowing the effectiveness of Dasawisma training in stunting prevention. The research respondents were 100 Dasawisma members from 10 villages. The effectiveness of the training was analyzed by means of different tests of pre-test and post-test values using the Paired T-Test. Training on stunting prevention for dasawisma was effective for increasing dasawimas knowledge in stunting prevention programs (p = 0.001). Age (p=0.510), education level (p=0.302), employment status (p=0.116) were not significantly related to the achievement of training objectives. Effective training increases Dawisma^s knowledge in stunting prevention. Keywords: Dasawisma- Training- Inter Professional Collaboration- Stunting Share Link | Plain Format | Corresponding Author (Athanasia Budi Astuti)

266	Medicine and Health Sciences	ABS-425
Effect of Different Solvent Types on Red Ginger Rhizome Extraction Process (Zingiber officinale Roscoe var rubrum) on Gingerol and Shagol Levels Kirana Anggraini*, Dyah Ayu Woro Setyaningrum, Laviany Putri Shihran, Isra Fauziyyah, Laela Wulansari, Hening Tyas Andayani Faculty of Medicine Universitas Trisakti Jakarta Indonesia Tropical Bio Pharmacy Study Centre, LPPM Intitute Pertanian Bogor Indonesia Facharztin der Innere Medizin, Stadtische Kliniken Monchengladbach Germany Abstract Red ginger (Zingiber officinale Roscoe var rubrum) is a spice commonly used in Indonesia. Red ginger is rich in various chemical constituents, such as phenolic compounds, terpenes, polysaccharides, lipids, organic acids, and fiber. The health benefits of ginger are mainly related to its phenolic compounds, such as gingerols and shogaols. Biological activities that have been found in red ginger include antioxidant, anti-inflammatory, antimicrobial, anticancer, neuroprotective, cardioprotective, respiratory protective, antiobesity, antidiabetic, antinausea, and antiemetic. Knowing the type of solvent that produces the most optimal levels of gingerol (6-gingerol, 8-gingerol, 10-gingerol) and 6-shogaol in the extract. Research in the laboratory, by macerating red ginger simplicia using several different solvents, namely water, n hexane, ethyl acetate, 96% ethanol, 70% ethanol, and 30% ethanol. The levels of gingerol and shogaol in each extract were tested using high performance liquid chromatography (HPLC). Red ginger n hexane extract contains 6-gingerol, 8 gingerol, 10 gingerol and 6 shagol of 123.08 mg/g- 26.39mg/g- 61.40mg/g- 24.41mg/g. Red ginger ETOH extract 96% contains 6 gingerols, 8 gingerols, 10 gingerols and 6 shagols of 12.34 mg/g- 2.68mg/g- 5.10mg/g- 2.73mg/g. The 70% ETOH extract of red ginger contains 6 gingerols, 8 gingerols, 10 gingerols and 6 shagols of 123.08 mg/g- 26.39mg/g- 61.40mg/g- 24.41mg/g. Red ginger ETOH extract 30% contains 6 gingerols, 8 gingerols, 10 gingerols and 6 shagols of 4.05mg/g- 0.89mg/g- 1.60mg/g- 1.52mg/g. Red ginger ethyl acetate extract contained 6 gingerols, 8 gingerols, 10 gingerols and 6 shagols of 81.79 mg/g- 16.70mg/g- 36.28mg/g- 14.70mg/g. Red ginger water extract contains 6 gingerols, 8 gingerols, 10 gingerols and 6 shagols of 31.15 mg/g- 1.91mg/g- 1.23mg/g- 2.13mg/g. red ginger extract which has the highest content of 6 gingerols, 8 gingerols, 10 gingerols and 6 shagols is found in n hexane extract Keywords: Zingiber officinale Roscoe var rubrum- gingerol- shagol Share Link | Plain Format | Corresponding Author (Rini Setiati)

267	Medicine and Health Sciences	ABS-426
The Effect of Different Types of Solvents in The Extraction Process of Javanese Chilies Fruits (Piper retrofractum Vahl) on Capsaicin Levels Kirana Anggraini*, Dyah Ayu Woro Setyaningrum, Laviany Putri Shihran, Isra Fauziyyah, Laela Wulansari, Hening Tyas Andayani Faculty of Medicine, Universitas Trisakti, Jakarta Indonesia Tropical Bio Pharmacy Study Centre of Institut Pertanian Bogor Indonesia Facharztin der Innere Medizin, Stadtische Kliniken Monchengladbach Germany Abstract Javanese Chili (Piper retrofractum Vahl) is one of the most common spices in Indonesia. Javanese Chili contains the main secondary metabolic including several alkaloids such as piperine, pipernonaline, guineensine, and piperoctadecalidine. Javanese chili fruit essential oil contains three main components namely &#946- caryophyllene, pentadecane dan &#946- bisabollene. In addition, there are new compounds in Javanese chilies, namely amide compounds, amide glycosides, phenylpropanoid glycosides, and alkaloids. Capsaicin is a bioactive substance in chili peppers that gives it a spicy and hot effect. Capsaicin has positive effects on health such as maintaining cardiovascular health, losing weight, relieving pain, anti-inflammatory, antibacterial and antiviral. Capsaicin levels in Javanese chilies are unknown. To identify the type of solvent that can produce optimum capsaicin compound on Javanese Chili extraction activity. Research in the laboratory, by macerating Javanese chili simplicia using several different solvents, namely water, n-hexane, ethyl acetate, 96% ethanol, 70% ethanol, and 30% ethanol. The capsaicin content of each extract was tested using High Performance Liquid Chromatography (HPLC). Javanese chili fruit n-hexane extract contains capsaicin of 101.58 mg/g. The 96% ETOH extract of Javanese chilies contains capsaicin of 426.34 mg/g. 70% ETOH extract of Javanese chilies contains capsaicin of 486.06 mg/g. ETOH extract 30% of Java chili fruit contains capsaicin of 73.34 mg/g. The ethyl acetate extract of Javanese chilies contains capsaicin of 785.53 mg/g. Java chili fruit water extract contains capsaicin of 6.99 mg/g. Javanese chili fruit extract with the highest capsaicin content is found in ethyl acetate extract. Keywords: Piper retrofractum Vahl- capsaicin- HPLC Share Link | Plain Format | Corresponding Author (Sulthoni Amri)

268	Medicine and Health Sciences	ABS-430
CARBOPOL-940 IMPROVES THE PHYSICAL PROPERTIES OF COCOA PEEL EXTRACT EMULGEL Nisa^ul Khoiriyah(a), Dwi Bagus Pambudi(b)*, Nuniek Nizmah Fajriyah(c), Eko Mugiyanto(d), Nur Izzah(e) Faculty of Health Sciences, University of Muhammadiyah Pekajangan Pekalongan, 51173, Indonesia Abstract Recently, the utilization of the herbal skincare industry has drawn much attention. One component utilized in formulations to provide a gel-like consistency and maintain the stability of a medical preparation is carbopol-940, a cosmetic gelling agent. It is frequently combined with an emulgator, triethanolamine. This study aims to assess the effect of blending Carbopol-940 and triethanolamine in the formulation of a cocoa peel extract gel using the Simplex Lattice Design (SLD) approach. In principle, using a magnetic stirrer, the water and oil phases are mixed to produce the gel at 700C. The procedure begins with dissolving Carbopol-940 in water, which is then combined with triethanolamine to form the base. After combining the gel base and emulsion, cocoa fruit peel extract is added. The SLD method was employed to evaluate the physical characteristics of emulgel (adhesion, viscosity, and dispersibility) to determine how Carbopol-940 and triethanolamine affected those characteristics. The result showed that using carbopol 940 and triethanolamine simultaneously significantly affected the adhesion and viscosity of cocoa peel extract emulgel. The ratio carbopol-940 to triethanolamine 1:8 gave the best physical properties- it shows a spreading power of 5.50-5.60 cm, an adhesive power of 1.16-1.25 seconds, and a viscosity of 20,456-21,472 mPa.s. Furthermore, compared to triethanolamine, carbopol 940 has a more substantial impact on the emulgel of cocoa peel extract. In conclusion, carbopol 940 and triethanolamine simultaneously had a major effect on the adhesion and viscosity of cocoa peel extract emulgel. Meanwhile, carbopol 940 has a greater effect on the emulgel of cocoa peel extract than triethanolamine. Keywords: Carbopol 940, triethanolamine, physical parameters, emulgel Share Link | Plain Format | Corresponding Author (Dwi Bagus Pambudi)

269	Medicine and Health Sciences	ABS-431
Formulation and Antibacterial Activity Of Liquid Soap Antiseptic Extract Of Guava Leaf (Psidium guava L.) Nuniek Nizmah Fajriyah (a), Urmatul Waznah (b*), Khusna Santika Rahmsari (c), Herni Rejeki (d) a, b, c, d) Faculty of Health Sciences, Pekajangan Pekalongan Muhammadiyah University Jalan Ambokembang No 8 Kedungwuni, Pekalongan, Central Java, Indonesia Abstract Diabetic wounds are a form of chronic complications of diabetes mellitus in the form of open wounds on the skin surface, which can be accompanied by local tissue death. Diabetes mellitus sufferers are at risk of 29 times diabetic wound complications. Treatment of diabetic wounds is carried out by cleaning them regularly to prevent infection and spread. One type of plant used in wound care is a plant that contains flavonoid, alkaloid, terpenoid, and saponin compounds- these secondary metabolite compounds are found in guava leaves. This study aims to make antiseptic liquid soap from guava leaf extract and test its antibacterial activity. The method used is to make antiseptic liquid soap preparations with tests carried out in the form of organoleptic tests, pH, and antibacterial activity tests using Escherichia coli and Staphylococcus aureus bacteria. The concentration of guava leaf extract used in the manufacture of antiseptic liquid soap preparations is 0.5%, 3%, and 5%. The data obtained is the antibacterial inhibition of antiseptic liquid soap preparations against Escherichia coli and Staphylococcus aureus bacteria. The results showed that guava leaf extract antiseptic liquid soap was proven to have antibacterial activity and could be made as an antiseptic liquid soap that was physically stable and had the best antibacterial effectiveness at a concentration of 0.5%. Keywords: Antibacterial- Diabetes- Guava Leaves- Liquid Soap Share Link | Plain Format | Corresponding Author (Nuniek Nizmah Fajriyah)

270	Medicine and Health Sciences	ABS-432
Health Assessment Of Women in Reproductive Age As Expectant Mothers Through Body Mass Index Examination Emi Nurlaela1*, Dian Kartikasari2 Bachelor Science in Nursing Program Study, Faculty of Health Sciences, Universitas Muhammadiyah Pekajangan Pekalongan Indonesia Abstract Women of childbearing age are of concern considering that as prospective mothers who will experience pregnancy, childbirth and postpartum, their health needs to be prepared. Maternal health in Indonesia is of concern to all parties because maternal and infant mortality rates are still high. One of the causes of maternal mortality rate is pre-eclampsia which is characterized by high blood pressure. This study aims to identify the body mass index of women of childbearing age. This research is a descriptive of quantitative research. The study was conducted by examining the height and weight of 78 respondents through accidental sampling technique. The results showed that the age of most respondents was 21 years (75.64%), respondents were categorized as thin 5.13%, normal 65.38%, overweight 21.79%, obesity 7.70%. Based on the results of this study, it was shown that 34.62% of women of childbearing age had risks to their health. Suggestions for future researchers to identify early on the health of women of childbearing age to prepare for the health of mothers and their babies in the future. Keywords: Women of Reproductive Age, Expectant Mothers, Body Mass Index Share Link | Plain Format | Corresponding Author (Dian Kartikasari)

Page 9 (data 241 to 270 of 382) | Displayed ini 30 data/page
<< PREV 1 2 3 4 5 6 7 8 9 10 11 12 13 NEXT >>

Powered By Konfrenzi Ultimate 1.832M-Build6 © 2007-2025 All Rights Reserved