Correlation between side effects of the extrapyramidal syndrome and quality of life in the outpatient unit of a hospital in Purworejo, Central Java Ayu Nissa Ainni, Fita Rahmawati
Pharmacy Study Program, Fakulty of Health Sciences, Gombong Muhammadiyah University, Kebumen, Central Java
Division of Pharmacology and Pharmacy Clinics, Muhammadiyah University, Surakarta Indonesia
Faculty of Pharmacy, Universitas Gadjah Mada
Abstract
Residual schizophrenia is a chronic condition of schizophrenia in which there is at least one clear psychotic episode and the symptoms are negative. First and second-generation antipsychotics are the therapy given, but the administration of antipsychotic drugs often causes side effects in the form of extrapyramidal syndrome which causes interruption of treatment and can worsen the patient^s condition and affect the quality of life. The purpose of this study was to analyze the relationship between extrapyramidal side effects and quality of life in outpatient residual schizophrenia at a hospital in Purworejo, Central Java. This study used a cross-sectional research design with prospective data collection. Intake for extrapyramidal syndrome side effects using the Naranjo Scale, while for the quality of life using the EQ-5D questionnaire. Data were analyzed using the Chi-Square or Fisher^s Exact test with a significant p-value ≤- 0.05 using the SPSS version 16.0 program. There is a significant effect of the incidence of ADRs with extrapyramidal syndrome symptoms on the quality of life of residual schizophrenia patients with a p-value <0.05. This research is useful for pharmacies in minimizing the risk of extrapyramidal syndrome side effects to improve the quality of residual schizophrenia patients
Keywords: Antipsychotics- extrapyramidal syndrome- quality of life- residual schizophrenia
