The Ruling of Novel Drugs to The Molecular Targets on Variant Pathologicalhis Henik Setiyaningsih 1, Imron Wahyu Hidayat1, Alfian Syarifuddin1, Setiyo Budi Santoso1, Ratna Wijayatri1a
1Department of Pharmacy, Universitas Muhammadiyah Magelang, Indonesia
Abstract
In recent decades, the investigation of novel drugs have not only been thoroughly profiled at the molecular level but have also been employed in extensive pharmacogenomic studies. Our paper present the ruling of novel drugs to the molecular targets on variant pathological. The study involves literature indexed by Scopus, and Pubmed databases, and the search uses a combination of the following keyword variants- ^ClinicalTrials.gov AND Genomic^,^ClinicalTrials.gov AND repurposing drug^ This study only used original articles in english l which were peer reviewed journals published between 2013 and 2022. Thus, the screening results of library sources were narrowed to 15 original articles papers that met the inclusion criteria. Our review shows that the target gene for treating depression, IL6R, has one of the best functional annotation scores among the target genes. Systemic inflammation, which is linked to the emergence of depression, is regulated by IL6R. identified sarilumab and satralizumab as two other IL6R-targeting medications. To identify prospective anti-breast cancer candidate medications, researchers compared these trends across tamoxifen, raloxifene, and paclitaxel. According to what Cell Walktrap (CW), Cell label propagation (CLP), Cell leading eigenvector (CLE), and Cell Infomap (CI) anticipated, we found that these medications are quite comparable to tamoxifen. Last, the molecular pathway of CD80 and CD86 were discovered, and it explains the risk of autoimmune diseases and may be considered a possible candidate gene for multiple sclerosis, such as anti-thymocyte immunoglobulin, abatacept, and belatacept. Our findings give up new opportunities for the development of pharmacogenomic-based follow-up studies on racial variations that have not previously been studied.
Keywords: repurposing drug, depression, breast cancer, multiple sclerosis
