Effect of Different Solvent Types on Red Ginger Rhizome Extraction Process (Zingiber officinale Roscoe var rubrum) on Gingerol and Shagol Levels
Kirana Anggraini*, Dyah Ayu Woro Setyaningrum, Laviany Putri Shihran, Isra Fauziyyah, Laela Wulansari, Hening Tyas Andayani

Faculty of Medicine Universitas Trisakti Jakarta Indonesia
Tropical Bio Pharmacy Study Centre, LPPM Intitute Pertanian Bogor Indonesia
Facharztin der Innere Medizin, Stadtische Kliniken Monchengladbach Germany

Abstract

Red ginger (Zingiber officinale Roscoe var rubrum) is a spice commonly used in Indonesia. Red ginger is rich in various chemical constituents, such as phenolic compounds, terpenes, polysaccharides, lipids, organic acids, and fiber. The health benefits of ginger are mainly related to its phenolic compounds, such as gingerols and shogaols. Biological activities that have been found in red ginger include antioxidant, anti-inflammatory, antimicrobial, anticancer, neuroprotective, cardioprotective, respiratory protective, antiobesity, antidiabetic, antinausea, and antiemetic.
Knowing the type of solvent that produces the most optimal levels of gingerol (6-gingerol, 8-gingerol, 10-gingerol) and 6-shogaol in the extract.
Research in the laboratory, by macerating red ginger simplicia using several different solvents, namely water, n hexane, ethyl acetate, 96% ethanol, 70% ethanol, and 30% ethanol. The levels of gingerol and shogaol in each extract were tested using high performance liquid chromatography (HPLC).
Red ginger n hexane extract contains 6-gingerol, 8 gingerol, 10 gingerol and 6 shagol of 123.08 mg/g- 26.39mg/g- 61.40mg/g- 24.41mg/g. Red ginger ETOH extract 96% contains 6 gingerols, 8 gingerols, 10 gingerols and 6 shagols of 12.34 mg/g- 2.68mg/g- 5.10mg/g- 2.73mg/g. The 70% ETOH extract of red ginger contains 6 gingerols, 8 gingerols, 10 gingerols and 6 shagols of 123.08 mg/g- 26.39mg/g- 61.40mg/g- 24.41mg/g. Red ginger ETOH extract 30% contains 6 gingerols, 8 gingerols, 10 gingerols and 6 shagols of 4.05mg/g- 0.89mg/g- 1.60mg/g- 1.52mg/g. Red ginger ethyl acetate extract contained 6 gingerols, 8 gingerols, 10 gingerols and 6 shagols of 81.79 mg/g- 16.70mg/g- 36.28mg/g- 14.70mg/g. Red ginger water extract contains 6 gingerols, 8 gingerols, 10 gingerols and 6 shagols of 31.15 mg/g- 1.91mg/g- 1.23mg/g- 2.13mg/g.
red ginger extract which has the highest content of 6 gingerols, 8 gingerols, 10 gingerols and 6 shagols is found in n hexane extract

Keywords: Zingiber officinale Roscoe var rubrum- gingerol- shagol

Topic: Medicine and Health Sciences