Preparation And Evaluation Of Microemulsion Containing Clove Oil Naelaz Zukhruf Wakhidatul Kiromah(a)*, Nining Sugihartini(b), Laela Hayu Nurani(c)
(a)Pharmacy, Faculty of Health Sciences, Universitas Muhammadiyah Gombong, Yos Sudarso Street 461, Kebumen, Jawa Tengah, Indonesia
(b,c)Faculty of Pharmacy, Universitas Ahmad Dahlan, Yogyakarta, Indonesia
Abstract
Clove oil (MABC) is one type of essential oil from clove flower buds have volatile properties at room temperature, unstable, very little solubility and cannot be mixed with water. Therefore, clove essential oil needs to be made in the form of a microemulsion. This study aims to formulate and characterize microemulsion preparations with clove flower essential oil as the active substance. This research begins with the analysis of compounds using GC MS and then to make a microemulsion base consisting of tween 80, PEG 400, isopropyl myristate, and aquadest using a pseduoternary diagram. The obtained microemulsion base was then added with 10% clove oil. Based on the results of the study, it was shown that the highest component of the compound in MABC was eugenol. The microemulsion base was the most optimum 1:9. The evaluation results showed that was stable during 30 days of storage both pH value and %transmittance and the base also showed viscosity, globule size, zeta potential that met the characteristics of microemulsion preparations. The MABC microemulsion was then formulated and showed that the evaluation results had a globule size of 17.69nm, a polydispersity index of 0.057, zeta potential of minus 5.36mV, a pH value of 7.3, a viscosity of 466.7 cPs, %transmittance 99.9.
