Formulation and Antibacterial Activity Of Liquid Soap Antiseptic Extract Of Guava Leaf (Psidium guava L.)
Nuniek Nizmah Fajriyah (a), Urmatul Waznah (b*), Khusna Santika Rahmsari (c), Herni Rejeki (d)

a, b, c, d) Faculty of Health Sciences, Pekajangan Pekalongan Muhammadiyah University
Jalan Ambokembang No 8 Kedungwuni, Pekalongan, Central Java, Indonesia

Abstract

Diabetic wounds are a form of chronic complications of diabetes mellitus in the form of open wounds on the skin surface, which can be accompanied by local tissue death. Diabetes mellitus sufferers are at risk of 29 times diabetic wound complications. Treatment of diabetic wounds is carried out by cleaning them regularly to prevent infection and spread. One type of plant used in wound care is a plant that contains flavonoid, alkaloid, terpenoid, and saponin compounds- these secondary metabolite compounds are found in guava leaves. This study aims to make antiseptic liquid soap from guava leaf extract and test its antibacterial activity. The method used is to make antiseptic liquid soap preparations with tests carried out in the form of organoleptic tests, pH, and antibacterial activity tests using Escherichia coli and Staphylococcus aureus bacteria. The concentration of guava leaf extract used in the manufacture of antiseptic liquid soap preparations is 0.5%, 3%, and 5%. The data obtained is the antibacterial inhibition of antiseptic liquid soap preparations against Escherichia coli and Staphylococcus aureus bacteria. The results showed that guava leaf extract antiseptic liquid soap was proven to have antibacterial activity and could be made as an antiseptic liquid soap that was physically stable and had the best antibacterial effectiveness at a concentration of 0.5%.

Keywords: Antibacterial- Diabetes- Guava Leaves- Liquid Soap

Topic: Medicine and Health Sciences