The Effect Of Doses Of Red Shoot Leaf Extract (Syzygium myrtifolium Walp) On Decreased Cholesterol Total Levels In Male White Wistar Rats In Vivo Denih Agus Setia Permana (a), Mika Tri Kumala Swandari (b), Imam Agus Faizal (c*), Dini Puspodewi (d), Aprilia Iin Aminia Putri (e)
a) D3 Pharmacy of Department, Faculty of Pharmacy, Science and Technology, Al-Irsyad Cilacap University, Indonesia
b) S1 Pharmacy of Department, Faculty of Pharmacy, Science and Technology, Al-Irsyad Cilacap University, Indonesia
c) Bachelor of Applied Medical Laboratory Technology Departement, Faculty of Pharmacy, Science and Technology, Al-Irsyad Cilacap University, Indonesia
*imamdfaizal[at]stikesalirsyadclp.ac.id
d) Bachelor of Applied Medical Laboratory Technology Departement, Faculty of Pharmacy, Science and Technology, Al-Irsyad Cilacap University, Indonesia
e) S1 Pharmacy of Department, Faculty of Pharmacy, Science and Technology, Al-Irsyad Cilacap University, Indonesia
Abstract
The prevalence of cholesterol in Indonesia is 66.41%. Central Java is among the five provinces with the highest levels of consumption of fatty, cholesterol, and fried foods, at 60.3%. The purpose of this study was to determine the effect of an extract of red shoot leaves (Syzyginium myrtifolium Walp). on decreasing the profile value of total cholesterol levels in male Wistar strain white rats. Red sprout leaf extract was obtained using the maceration process. Red shoot leaf extract contains anthocyanin compounds that can lower cholesterol, flavonoid compounds, and tannin compounds. his research is a purely experimental design with a before-and-after test with a control group using 30 rats divided into 5 groups, negative control (rats with hypercholesterolemia and Na-CMC 0.5%), positive controls (rats with hypercholesterolemia and 10 mg simvastatin). , administration of red shoot leaf extract at extract dose 1 (200 Mg/Kg BW), extract dose 2 (250 Mg/Kg BW), and extract dose 3 (300 Mg/Kg BW). The total number of test animals used was 30 animals, each group consisted of 5 rats. The results of the ANOVA repeated measures test/Friedman test analysis showed that the activity of The Red shoot leaves (Syzyginium myrtifolium Walp) as a cholesterol-lowering agent for reducing total cholesterol levels was demonstrated with the potential efficacy in extract group 3 (300 mg/kg BW) with a significant value of 0.647.
Keywords: Red sprout leaf, total cholesterol, LDL, HDL, triglycerides, Decreased, Wistar rat
