THE EFFECT OF TELANG FLOWER EXTRACT ON THE HEPAR CATALYST ENZYME OF MICE EXPOSED TO CIGARETTE SMOKE Agus Suprijono, A. Ariani Hesti W, Endang Setyoningsih
Teaching Staff at the Semarang Pharmacy Foundation College of Pharmacy, Semarang, Indonesia
Abstract
Introduction : Cigarettes contain more than 4000 chemicals and around 200 of them are harmful to health. Some components of cigarette smoke are gases, such as carbon monoxide (CO), carbon dioxide (CO2), hydrogen cyanide (HCN), and nitrogen oxide (NOx) which have the potential to cause free radicals. Several other components of cigarette smoke are solid particles, such as nicotine, phenol, tar and cadmium. Continuous exposure to cigarettes results in decreased levels of the body^s antioxidants and causes oxidative stress. Butterfly/Telang flower extract has antioxidant properties. With the presence of these antioxidants, it can reduce the number of free radicals formed from the lipid peroxidation process. The catalase enzyme, which is one of the antioxidant enzymes, is used to determine antioxidant levels in mice exposed to cigarette smoke
Purpose :This research aims to analyze the effect of butterfly/telang flowers extract ons mice hepatic catalase enzyme that exposed to cigarette smoke.
Method : Sample of this research was 20 mice divided into 4 groups. Normale group (N) given standard feed, control negative group (K0) given cigarette smoke, K1 group given cigarette smoke and telang flowers extract 200 mg/kgBB, and K2 group given cigarette smoke and telang flowers extract 400 mg/kgBB Treatment was carried out for 10 days and continued with measuring hepatic catalase enzyme levels.
Main Finding : All samples given cigarette smoke responded to increased oxidation and when given telang extract was able to have a significant effect. The results of the Anava test showed significant differences between all groups.
Implication : The benefits of this research can be used as a reference for the use of butterfly pea/telang flowers as antioxidants, both in the fields of chemistry and pharmacology
