Identified IL6R as the most promising target gene for depression according to
clinical and preclinical evidence. IL6R was one of the target genes with the highest
functional annotation score and was a highly promising target in the treatment of
depression. IL6R regulates systemic inflammation, which is associated with
depression development.
Results indicatethat the Walktrap (CW) algorithm yields the best performance for
detecting functional clusters in the PPI networ. Based on the validation result, we
found that the CW cluster detection algorithm showed the best ability to extract
functional clusters from the network. To better understand the potential application
of these drugs in breast cancer treatment.
your research is very interesting, what is the pathological effect on autoimmune diseases? Are there proper prescription rules for autoimmune sufferers while current drugs containing immunosuppressants have a bad effect on patients?
thanks
Replies:
Preclinical and clinical validation is necessary and important to ensure whether our
drug candidates produced the desired interaction (intended from the study), any
undesired side effects, or suboptimal effects.
yes there are recipe rules the drug repurposing approach has several advantages
compared to the traditional ones, such as time and cost-effectiveness , safety profile
(drugs have previously passed clinical trials), dosage, and the toxicity of existing
drugs has been vetted
ClinicalTrials.gov is a web-based resource that provides patients, their family
members, health care professionals, researchers, and the public with easy access to
information about publicly and privately supported clinical studies in a variety of
diseases and conditions.
ClinicalTrials.gov is a registry of clinical trials. It is run by the United States National
Library of Medicine at the National Institutes of Health, and is the largest database
of clinical trials, holding registrations of more than 329,000 trials from 209
countries.
