Department of Food Science and Biotechnology
Faculty of Agricultural Technology, Universitas Brawijaya
Jl. Veteran, Malang 65145, Jawa Timur, Indonesia
*Email: tjmahatmanto[at]ub.ac.id
Abstract
Ribosomal Bioactive peptides are gene-encoded peptides that play a crucial role in cellular processes and exhibit a variety of functional properties, including antimicrobial activity, immunomodulatory, and anti-inflammatory. These peptides consist of 2-50 amino acids that are synthesized through direct gene expression and mRNA translation, thus directly related to genetic regulation in living organisms. Unlike non-ribosomal peptides and protein-derived peptides, ribosomal peptides are evolutionarily conserved and exhibit remarkable functional diversity across species. Food plants are a rich source of ribosomal peptides with diverse bioactivities, including antioxidant, anticancer, and wound healing properties. The UniProt (Universal Protein Resource) database provides comprehensive sequence and annotation data, facilitating the systematic analysis of ribosomal peptides, particularly those from plants. Several plant bioactive ribosomal peptides have been successfully commercialized as functional ingredients in the food, pharmaceutical, and cosmetic industries. This mini-review comprehensively analyzes bioactive ribosomal peptides from edible plants documented in the UniProt database, examining their structural characteristics, biological mechanisms, and therapeutic potential. This review contributes to advancing the understanding of plant-derived ribosomal peptides and supports the development of novel bioactive compounds for therapeutic and nutritional applications.
