Anti-inflammatory Effectivity and Physical Stability Test of Nanoemulgel Containing Marjoram (Origanum majorana L.) Essential Oil Ungsari Rizki Eka Purwanto1*, Mighfar Syukur2, Tris Harni Pebriani3, Ika Puspitaningrum4
1,3Department of Pharmaceutical Technology, Stifar Yayasan Pharmasi Semarang, Semarang, Indonesia
2Department of Pharmaceutical Chemistry, Stifar Yayasan Pharmasi Semarang, Semarang, Indonesia
4Department of Pharmacology and Clinical Pharmacy, Stifar Yayasan Pharmasi Semarang, Semarang, Indonesia
Abstract
Introduction : The ability of marjoram essential oil (MEO) to reduce pro-inflammatory agents, C-reactive protein (CRP), is gaining attention these days. The nanoemulgel development is needed to increase permeation of the active components. Furthermore, proving the anti-inflammatory effectiveness and stability of MEO nanoemulgel is the key to the success of the formulation.
Purpose : To formulate and perform anti-inflammatory and physical stability studies on a nanoemulgel formulation containing MEO.
Method : MAE (Darjeeling CAS 8015-01-8) nanoemulgel was prepared. The edema volume formation with carrageenan is a method used for anti-inflammatory test. The stability studies used are accelerated methods and cycling tests.
Main Finding : MEO nanoemulgel shows anti-inflammatory activity, where 2% MEO nanoemulgel produces a better anti-inflammatory effect compared to 1% MEO because it has a greater reduction in edema volume and CRP levels. Independent T-test results show that there are no significant differences in all physical preparation parameters, before and after stability test.
Implication : MEO nanoemulgel has the potential to be developed into a topical anti-inflammatory preparation. Further phase 1 clinical trials are needed to determine its anti-inflammatory effectiveness in humans. This research can be useful in the fields of Pharmaceutical Technology and Pharmacology, especially in the development of natural ingredient-based pharmaceutical preparations.
