THE EFFECT OF NITRIC OXIDE AND HbA1c ON MUSCLE MASS IN ELDERLY WITH DIABETES MELLITUS Desy Puspa Putri1), Nurhasan Agung Prabowo1), Fatichati Budiningsih2), Agung Susanto3)
1) Internal Medicine Department, Faculty of Medicine, Sebelas Maret University, Indonesia
2)Geriatric Division, Internal Medicine Department, Faculty of Medicine, Sebelas Maret University/ Dr. Moewardi Hospital Surakarta, Indonesia
3)Nephrology Division, Internal Medicine Department, Faculty of Medicine, Sebelas Maret University/ Dr. Moewardi Hospital Surakarta, Indonesia
Abstract
Background. Diabetes Mellitus (DM) in the elderly is followed by the incidence of sarcopenia, one of which is a decrease in muscle mass. Hyperglycemia and decreased Nitric Oxide (NO) levels in the elderly will affect the degradation and regeneration of skeletal muscle, thereby affecting muscle mass.
Aim. To determine the effect of NO and HbA1c levels on muscle mass in elderly with DM.
Methods. This is a cross-sectional study on 30 elderly with DM who visited the Geriatric Clinic. We take the serum for NO and HbA1c assays, and muscle mass measurement by DXA. We used SPSS 22 for statistical analysis using Shapiro Wilk test for data normality and correlation analysis and multiple linear regression with a significance value at p ≤- 0.05.
Results. We found the BMI of subjects varied, with low average handgrip strength and fairly normal TUG results. NO levels have a positive and significant effect on muscle mass with a significant degree of 5 percent (p = 0.003). HbA1c has a negative and significant effect on muscle mass (p = 0.04). The multiple correlation test results showed that NO and HbA1c together had a significant effect on muscle mass (p = 0.001)
Conclusion. NO levels were shown to have a positive and significant effect on muscle mass and HbA1c levels were shown to have a negative effect on muscle mass in elderly with DM. NO and HbA1c levels also simultaneously affect muscle mass and contribute as predictor factors for muscle mass in elderly with DM.
Keywords: NO, HbA1c, muscle mass, elderly, DM
Topic: Medical : basic science, clinical, translational research, medical education, and miscellaneous
