THE CORRELATION BETWEEN MDS UPDRS III WITH DEPRESSION, ANXIETY, AND FATIGUE SYMPTOMS IN PARKINSON DISEASE Ervina Arta Jayanti1, Suroto1, Diah Kurnia Mirawati1, Subandi1, Rivan Danuaji1, Pepi Budianto1, Yetty Hambarsari1, Baarid Luqman Hamidi1, Hanindia Riani P1, Ira Ristinawati1, Teddy Tejomukti1, Andi Ario Tedjo1, Ardisa Permata Putri2, Andry Nurwahyu Putra2
1Neurology Staff, Faculty of Medicine, Sebelas Maret University/RSUD dr. Moewardi Surakarta, Indonesia
2Resident of Neurology, Faculty of Medicine, Sebelas Maret University/RSUD dr. Moewardi Surakarta, Indonesia
Abstract
ABSTRACT
Parkinson is one of the most common neurodegenerative diseases among people aged 40-70. One of Parkinson non-motor symptoms is depression, anxiety, and fatigue. Those symptoms significantly worsen the quality of life of people with Parkinson. This study aims to determine and analyze the relationship between MDS UPDRS III on symptoms of depression, anxiety, and fatigue in Parkinson. This research is an observational analytic quantitative with a cross-sectional study approach. The subjects were all Parkinson patients assessed with MDS UPDRS III (motoric scale) in the Neurology department RSUD Dr Moewardi from July 2022-September 2022. The severity of depression, anxiety, fatigue was assessed using Hamilton Depression Scale, Hamilton Anxiety Scale, and Fatigue Severity Scale. The Spearman correlation test was conducted to determine the correlation between MDS UPDRS III scores and the severity of depression, fatigue and anxiety in Parkinson patients. A statistically significant result was obtained between MDS UPDRS III scores with depression scale (p<0.05- 0.000), anxiety scale (p<0.05- 0.000) and fatigue scale (p<0.05-0.380). From the result of correlation, there is a solid and positive relationship between the degree of UPDDRS III and depression, anxiety and fatigue symptoms. The higher the UPDRS III value, the more likely the patient is to experience depression, anxiety and fatigue.
Keywords: Parkinson, Depression, Anxiety, Fatigue, UPDRS III
Topic: Medical : basic science, clinical, translational research, medical education, and miscellaneous
