zinc supplementation reduces myeloperoxidase level in chronic suppurative otitis media without cholesteatoma Sudrajad HADI1*, Pratiwi DEWI1, Primadewi NOVI1, Nurhidayah1
Othorhinolaryngology Deparment, Sebelas Maret Universty Surakarta Indonesia
Abstract
Background: Chronic suppurative otitis media (CSOM) is a chronic infection and inflammation of the middle ear and mastoid cavities characterized by the presence of otorrhoea through perforation of the tympanic membrane. Myeloperoxidase (MPO) is an oxidative enzyme with antimicrobial activity, which utilizes H2O2 to produce hypochlorous acid and other toxic substances in neutrophil phagolysosomes. It has been reported that MPO plays an important role in chronic processes such as CSOM. Zinc is believed to provide benefits as a modulator effect in the inflammatory cascade that can reduce the hyperinflammatory response to infectious agents so that it is expected to reduce MPO levels. Objectives: To analyze the effect of Zinc on MPO in CSOM without cholesteatoma patient. Methods: This research was conducted at the ENT Clinic Dr. Moewardi Hospital Surakarta, Indonesia from July - Augustus 2022 with the pretest-posttest control group design. Results: The mean level of MPO was decrease significantly from 3.17 +- 1.47 ng/mL to 0.65+- 0.48 ng/mL (p=0.001) after intervention with zinc supplementation in the study group, compared to the control group fom 3.08+- 1.05 ng/mL to 2.45+- 0.78 ng/mL (p=0.082). There was also significant difference in MPO level changes in the study group compares to the control group (0.63 +- 1.13 ng/mL vs 2.51 +- 1.24 ng/mL) (p=0.001) Conclusion: Zinc has modulator effect in inflammation cascade that can decrease MOP levels in CSOM. Therefore, the zinc supplementation is recomended in patients with CSOM without cholesteatoma.
