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Abstract ABS-391

The Role of Genetic Mutation on Schizophrenia: A Basic Review Prior to Pharmacogenomics Dhea Nur Hikmah1, Alfian Syarifuddin1, Setiyo Budi Santoso1, Ratna Wijayatri1, Imron Wahyu Hidayat1,a Corresponding Author: Dhea Nur Hikmah

Question from Ms. Zaleha Rumadi 2022.12.21 14:51:33 How is the mechanism of GWAS for approachment of drug development in Schizophrenia?

Reply from Ms. Dhea Nur Hikmah 2022.12.21 14:55:19 Specifically, GWAS meta-analysis in schizophrenia by the Psychiatric Genomics Consortium (PGC) schizophrenia group has identified 128 independent associations spanning that meet genome-wide significance in 108 genomic regions notably including the dopamine D2 receptor locus, but also many other neurotransmitter genes, especially those involved in central nervous system (CNS) calcium and glutamate signalling. Thank you for your question

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