A combination supplement of bitter melon extract (Momordica charantia L.) with snakehead fish (Channa striata) powder has no effect as an anti-glycation agent in Type 2 diabetes mellitus: a randomized controlled trial Fahrun Nur Rosyid, Muhtadi, Andi Suhendi, Ahmad Fadhlur Rahman
Universitas Muhammadiyah Surakarta
Abstract
Diabetes mellitus (DM) is characterized by hyperglycemia. Chronic hyperglycemia can cause interactions between vascular and inflammatory cells, resulting in advanced glycation end products (AGEs).
This study aims to examine the combined supplement of bitter melon leaf extract with snakehead fish powder as an anti-glycation agent in Type 2 diabetes mellitus
This study used a randomized, double-blinded, placebo-controlled trial. Eighty patients with Type 2 diabetes mellitus (DMT2) who met the criteria were divided into 2 groups, namely: 40 patients as the treatment group was given supplements of a combination of bitter melon leaf extract and snakehead fish powder, and the control group 40 patients received a placebo. This intervention was carried out for 4 weeks. AGEs levels were measured at baseline and the end of treatment. Data analysis using paired t-test and independent t-test, with a significance limit of p <0.05.
Supplements combined with bitter gourd leaf extract and snakehead fish powder have no effect as anti-glycation in Type 2 diabetes mellitus.
This Supplements the combination of bitter gourd leaf extract and snakehead fish powder can used for further research in field of complementary therapy in diabetic treatment
