FORMULATION AND ANTIBACTERIAL TESTS OF SERUM PREPARATION OF ETHANOL EXTRACT OF GUAVA LEAVES (Psidium guajava L) AS AN ANTI ACNE Neni Sri Gunarti a), Shintia, Farhamzah, Eko Sri Wahyuningsih, Putri Agustina
Department Pharmacy, Univesitas Buana Perjuangan Karawang
Author Emails
a) neni.gunarti[at]ubpkarawang.ac.id
Abstract
The guava leaf plant (Psidium guajava L) is a plant that can be found in almost every region in Indonesia. The part of the guava leaf that has been extensively researched and contains anti-acne properties is the leaf. In previous studies, it was known that guava leaves have antibacterial activity against Propionibacterium acnes, Staphylococcus aureus and Staphylococcus epidermis which are the causes of acne. to determine the antibacterial activity of serum preparations of guava leaf extract against Propionibacterium acnes. The extraction method used was maceration using 96% ethanol. Phytochemical screening was carried out to determine the content of secondary metabolites in the guava leaf extract. Furthermore, the ethanol extract from guava leaves was used as an active substance in the manufacture of serum with various concentrations of 3.75, 2.5, and 1.25%. Physical evaluation of serum preparations was carried out by organoleptic tests, homogeneity, pH tests, spreadability, and viscosity. The research results found that formula III had the best inhibition where the diameter of the resulting inhibition zone was 19.0 mm and included in the strong category.
