Effect of Sweet Orange and Pomegranate Peel Extract Combination on in Vivo Antidiabetic and Wound Healing Activity Evi Soviaa*, Rini Sundari Harjonob, R.J Nurjatinc, Wisna Dirgahasari Asmarad, Aktiva Syifaaur Rohmahd
aLaboratory of Pharmacology, Faculty of Medicine, Universitas Jenderal Achmad Yani, Cimahi, Indonesia
bLaboratory of Clinical Pathology, Faculty of Medicine, Universitas Jenderal Achmad Yani, Cimahi, Indonesia
cLaboratory of Physiology, Faculty of Medicine, Universitas Jenderal Achmad Yani, Cimahi, Indonesia
dFaculty of Medicine, Universitas Jenderal Achmad Yani, Cimahi, Indonesia
Abstract
Sweet orange (Citrus sinensis) and pomegranate (Punica granatum) peel known have an antihyperglycemic effect. This study investigated the effect of the combination of both plants on blood glucose level and wound healing in alloxan induced diabetes rats. Rats were divided into 4 groups. One normal group and 3 treatments groups that induced by intraperitoneal injection of a single dose of alloxan 125 mg/kg and given a combination of sweet orange and pomegranate extracts. The treatment was given for 12 days. Blood glucose levels and the rate of wound closure were measured on the 13th day. The combination of sweet orange and pomegranate peel extracts showed significant (p ≤- 0.05) reduction in blood glucose and wound closure time compared with diabetes control. Based on these results, a combination of sweet orange and pomegranate have a potential effect as an antidiabetic agent and treatment of chronic wounds in diabetes.
