THE EFFECT OF RAMBUTAN HONEY ON DECREASE BLOOD GLUCOSE STREPTOZOTOCIN-INDUCED RAT COMPARED TO RUTIN Iis Inayati Rakhmat (a), Euis Reni Yuslianti (a), Welly Ratwita (b), Nurul Sofiana Mutiadewi (c*)
a) Biochemistry and Biological Molecular Department of Jenderal Achmad Yani University
b) Pharmacology Department of Jenderal Achmad Yani University
c) Medical Faculty of Jenderal Achmad Yani University
Terusan Jend. Sudirman Street No. 40533, Baros, Kec. Cimahi Tengah, Cimahi City, West Java 40525
*nurul.sofiana[at]gmail.com
Abstract
Diabetes mellitus (DM) is a chronic metabolic disease characterized by hyperglycemia due to insulin work disorders, insulin secretion disorders, or both. Rambutan honey as a natural ingredient has been studied to reduce oxidative stress, to protect pancreatic beta cells from damage, and to increase insulin secretion by pancreatic beta cells. Rutin as secondary antioxidants increase insulin secretion and reduce free radical formation. This study aims to determine the effect of rambutan honey on blood glucose levels in rats induced by streptozotocin compared to rutin. This research is a laboratory experimental study with a total sample of 24 experimental animals consisting of 4 groups, namely negative control (NC), positive control (PC), and 2 treatment groups (T1-T2). Glucose levels were measured using the GOD-PAP method and were analyzed statistically (T-dependent, Anova, Duncan p <0.05). The results showed that rambutan honey and rutin could significantly reduce blood glucose levels (p=0.008 and p=0.010). This study concludes that both rambutan honey and rutin can reduce blood glucose level because they are antioxidant agents which have antihyperglycemic effects and rambutan honey can decrease blood glucose better than rutin because of more diverse mechanisms.
