Safety Evaluation of Antiparasitic Combination Afoxolaner and Milbemycin Oxime in Dog Tri Isyani Tungga Dewi1, Upik Kesumawati2, Susi Soviana2, Risky Andrea1, Nurul Annisa1, Hamdika Yendri1 , Deni Noviana1,3
1 Veterinary Teaching Hospital, Faculty of Veterinary Medicine, IPB University
2Division of Parasitology and Medical Entomology, Department of Animal Infectious Diseases and Veterinary Public Health, Faculty of Veterinary Medicine, IPB University
3Division of Surgery and Radiology, Department of Clinic, Reproduction and Pathology, Faculty of Veterinary Medicine, IPB University
Abstract
Antiparasitic treatment through oral application for both ectoparasites and endoparasites has a good level of efficacy. This study aimed to determine the safety of the oral anti-parasitic drug combination afoxolaner which is effective on ticks and fleas, and milbemycin oxime which is effective on nematodes. A total of three Beagles weighing 10 kg were given a combination of afoxolaner and milbemycin oxime 3 times the recommended dose (Afoxolaner 150 mg and Milbemycin oxime 30 mg). Clinical observations of the respiratory system, circulatory system and digestive system were carried out at 1, 2, 3 and 24 hours after drug administration. Examination of blood samples was also performed to determine the hematological profile. Blood samples were collected 2 times, namely before administering the drug and 24 hours after administration. The results of the study showed that there were no any clinical symptoms of intoxication after treatment. There were no abnormalities in the frequency, rhythm and type of breathing. The intensity, frequency and rhythm of the heart were still normal. Body temperature, capillary refill time values ​-​-were in normal ranges category. Symptoms of abnormality in digestive system such as hypersalivation, vomiting and diarrhea were not found. Statistical analysis showed that there were no significant difference (p> 0.05) in the total number of erythrocytes, hemoglobin levels, hematocrit values, as well as erythrocyte index values. As conclusion, the combination of afoxolaner and milbemycin oxime as drug administration does not have any effect intoxication.
