ICVS 2020
Conference Management System
Main Site
Submission Guide
Register
Login
User List | Statistics
Abstract List | Statistics
Paper List
Presentation Video
Online Q&A Forum
Access Mode
Ifory System
:: Abstract ::

<< back

BISPHENOL A INCREASES MALONDIALDEHYDE AND APOPTOTIC INDEX IN THE LIVER OF MALE RATS
Risha Catra Pradhany (a*), I Nyoman Suarsana (b), I Gusti Ayu Agung Suartini (b), Ferbian Milas Siswanto (c)

a) Study Program of Veterinary Medicine, Hasanuddin University, Makassar 90245, Sulawesi Selatan, Indonesia
*rishacatra[at]yahoo.com
b) Department of Biochemistry, Faculty of Veterinary Medicine, Udayana University, Denpasar 80234, Bali, Indonesia
c) Department of Biotechnology, Dhyana Pura University, Badung 80361, Bali, Indonesia


Abstract

Bisphenol A is a well-known toxin whose effects on reproductive toxicities. However, recent years, it has also been known BPA causes oxidative stress. Oxidative stress is one of the factors causing organ damage, this study aims to prove the effect of oral bisphenol A administration on malondialdehyde levels and apoptotic index in rat liver. This study used a posttest only control group design. Subjects were 14 male Sprague Dawley rats, male, aged 8-10 weeks, body weight 180 grams, and healthy. The control group (P0), 7 rats, were given a placebo of 1 ml aquadest for 21 days- while the treatment group (P1), 7 rats, were given 400 mg/kgBW of BPA for 21 days. The results showed that the P1 group had higher hepatic MDA levels (3,33- 0,27 nmol/mg.prot) and significantly different (p<0,001) than the P0 group (2,67- 0,14 nmol/mg.prot). In addition, the P1 group had a higher apoptotic index (11,21- 2,26%) and significantly different (p<0,001) than the P0 group (2,19- 0,97%). Based on these results, it can be concluded that oral administration of bisphenol A increases malondialdehyde and apoptotic index in the liver of male Sprague dawley rats.

Keywords: Bisphenol A- Malondialdehyde- Apoptotic Index- Liver

Topic: Biology and Biomedical Science

Plain Format | Corresponding Author (Risha Catra Pradhany)

Share Link

Share your abstract link to your social media or profile page

ICVS 2020 - Conference Management System

Powered By Konfrenzi Premium 1.832L-Build7 © 2007-2025 All Rights Reserved