Formulation and Kinetic Evaluation of Curcumin Nanogel Based on Alginate Dialdehyde Saviola, Fitrianti Darusman, Hilda Aprilia Wisnuwardhani, Hanifa Rahma, Arlina Prima Putri
Department of Pharmacy, Faculty of Mathematics and Natural Science, Universitas Islam Bandung, Ranggagading 8, Bandung, 40116, Indonesia
Abstract
Cancer is a potentially fatal disease caused by uncontrolled and abnormal cell growth. It is characterized by unregulated cell proliferation at a high rate, leading to continuous cell division . Breast cancer is among the primary factors underlying women mortality. Conventional chemotherapy is frequently associated with high systemic toxicity and limited bioavailability, thereby highlighting the necessity for more effective and less harmful therapeutic options. Biological therapy, also known as biologically based practice, is an alternative cancer treatment that utilizes natural compounds to directly or indirectly destroy cancer cells by triggering an immune response. One promising natural compound for cancer therapy is curcumin, also known as diferuloylmethane (C21H20O6), the orange-yellow pigment found in Curcuma longa. This study developed a curcumin-based nanogel using dialdehyde alginate via the inverse microemulsion method to enhance curcumin stability and delivery. Characterization included organoleptic tests, homogeneity, pH, viscosity, particle size, polydispersity index (PDI), zeta potential, entrapment efficiency, and drug release kinetics. The optimal formulation, F4, showed a particle size of 144,63 nm, PDI 0.536, and zeta potential -32.67 mV, indicating good stability. Release kinetics study shows that it followed the Higuchi model, suggesting controlled release. This nanogel formulation demonstrates alginate as a potential matrix for as curcumin encapsulation, contributing to the development of nanotechnology-based pharmaceuticals.
