CORRELATIONS OF EXPRESSION OF KLF5, FHIT, AND DLG2 WITH CERVICAL CANCER
Alvionita Kogoya (a), Monica Dwi Hartanti (a*, b, c)

a) Department of Biology, Faculty of Medicine, Universitas Trisakti
Jl. Kyai Tapa No.260, West Jakarta, Indonesia
*mdhartanti[at]trisakti.ac.id

b) Center for Artificial Intelligence and Advanced Technology, Universitas Trisakti
Jl. Kyai Tapa No.1, West Jakarta, Indonesia

c) Center for Biomedical Research, The Research Organization for Health, National Research and Innovation Agency
Jl. Raya Jakarta - Bogor KM 46, Cibinong, West Java, Indonesia

Abstract

Cervical cancer is the fourth most frequent cancer in women cause by Human Papilloma Viruses. Previous studies have shown that several genes including KLF5, FHIT and DLG2 can play a role in the process of cervical cancer progression. This study aims to analyze the correlation between the KLF5, FHIT, DLG2 genes in cervical cancer tissue. Cancer tissues were obtained using biopsy. The cDNA samples were collected through RNA isolation, nanophotometer and PCR. All samples were analyzed with qPCR. The genes expression of KLF5, FHIT and DLG2 were not significant to cervical cancer (p>0.05). Based on Spearman^s correlation test analysis, it showed that there was no significant correlation between genes expression of KLF5, FHIT, DLG2 on cervical cancer progression. This study can be a reference in biomedical science for delving deeper into genes associated with cervical cancer progression. By expanding the sample size, the FHIT, DLG2 and KLF5 genes can still be developed as cervical cancer biomarkers.

Keywords: KLF5- FHIT- DLG2- HPV- Cervical Cancer

Topic: Medicine & Health Sciences