Potential as Photoprotective, Antioxidant and Anti-inflammatory of Flavonoid Isolate from Okra Fruit (Abelmoschus esculentus L.)t
Christina Astutiningsih1*, Herni Setyawati2, Ali Rahmat3, Faidliyah Nilna Minah4

1 Semarang Pharmaceutical College, Semarang, 50192, Indonesia
2 Universitas Anwar Medika, Sidoarjo, 61253, Indonesia
3 Badan Riset dan Inovasi Nasional, Indonesia
4 Institute Teknologi Nasional, Malang, Indonesia

Abstract

Article Title : <Potential as Photoprotective, Antioxidant and Anti-inflammatory of Flavonoid Isolate from Okra Fruit (Abelmoschus esculentus L.)>

1. Authors
: <Christina Astutiningsih1*, Herni Setyawati2, Ali Rahmat3, Faidliyah Nilna Minah4>

2. Corresponding Email
: christinaastutiningsih@gmail.com

3. Affiliation
: <1 Semarang Pharmaceutical College, Semarang, 50192, Indonesia
2 Universitas Anwar Medika, Sidoarjo, 61253, Indonesia
3 Badan Riset dan Inovasi Nasional, Indonesia
4 Institute Teknologi Nasional, Malang, Indonesia >

4. Introduction
: < Long-term exposure to UV radiation can induce skin disorders, such as cancer and photo-allergic reactions. Natural products are being considered for their potential as non-irritating and effective sunscreen resources, owing to their UV absorption, antioxidant, and anti-inflammatory properties.>

5. Purpose
: < This study aimed to assess the level of quercetin and investigate the in vitro ultraviolet radiation protection, antioxidant activity, and anti-inflammatory potential of isolated flavonoids from Okra Fruit (Abelmoschus esculentus L.). >

6. Method
: <Isolation is carried out by TLC Preparative and recrystallization methods. UV Protection, antioxidant and anti-inflammatory test using spectrophotometer Shimadzu U-1700.>

7. Main Finding
: < In UV protection testing, at a concentration of 100 ppm, the SPF value was measured at 15.08. Furthermore, the antioxidant activity test of the okra fruit flavonoid isolate yielded an IC50 value of 25.67 ppm. The isolated compound inhibited protein denaturation at 50 ppm, with an inhibitory efficacy of 50.65%. >

8. Implication
: < Based on these findings, it can be concluded that the isolated compound possesses anti-inflammatory activity. There is a strong positive correlation between SPF effectiveness, antioxidant activity, anti-inflammatory effects, and and flavonoid content >

9. Keywords
: <Photoprotective, antioxidant, anti-inflammatory, flavonoid, okra fruit >

Keywords: Photoprotective, antioxidant, anti-inflammatory, flavonoid, okra fruit

Topic: Medicine & Health Sciences