MORINGA OLEIFERA EXTRACT REDUCES DISEASE ACTIVITY IN RHEUMATOID ARTHRITIS PATIENTS
Nurhasan Agung Prabowo*, Arief Nurudhin, Yulyani Werdiningsih, Wachid Putranto, Tri Kusumo, Hartono, and Desy Puspa Putri

1 Doctoral Program of Medical Sciences, Faculty of Medicine, Universitas Sebelas Maret, Ir Sutami Street No 36A, Kentingan, Jebres, Surakarta, 57126
2 Department of Internal Medicine, Faculty of Medicine, Universitas Sebelas Maret, Ir Sutami Street No 36A, Kentingan, Jebres, Surakarta, 57126
3 Department of Internal Medicine, Universitas Sebelas Maret Hospital, Universitas Sebelas Maret, Ahmad Yani Street No 200, Makam Haji, Sukoharjo, Surakarta, 57161

Abstract

Rheumatoid arthritis (RA) is a systemic autoimmune disease targeting joints. Remission in Indonesia on RA treatment is 62.3%, with a record of the many side effects of RA therapy. Therefore, new drugs that are effective and safe for managing RA are needed. Moringa oleifera has been shown to have anti-inflammatory, anti-arthritis, and immunosuppressant effects for treating rheumatoid arthritis. This study aimed to prove the effect of moringa oliefera extract on the DAS28-hsCRP score of RA patients. This study was in the form of a Randomized Controlled Trial (RCT) with a sample of 33 people who were divided into two groups, namely the treatment group (n=15, Moringa oleifera extract 40.50 mg/kg BW/day) and the control group (n=18, placebo). This study lasted for 30 days. Disease activity levels (DAS28-CRP, DAS28-LED) were assessed before and before intervention. Analysis of the data used using paired t-test and independent t-test. The number of significance was p <0.05. The results showed the improvement of DAS28-hsCRP before and after administration of Moringa Leaf Extract (MO) in the treatment group (p=0.001). The Delta-DAS28-hsCRP difference was more significant in the treatment group than in the control group (p=0.013). Moringa leaf extract administration reduced DAS28-hsCRP scores in RA. Patients.

Keywords: DAS28-hsCRP, Disease Activity, Moringa oleifera, Rheumatoid Arthritis

Topic: Medical : basic science, clinical, translational research, medical education, and miscellaneous