POTENTIAL ZOONOSES IN SARS-CoV 2
Sayu Putu Yuni Paryati

Universitas Jenderal Achmad Yani

Abstract

Zoonotic diseases are infections that are transmitted from animals to humans. The World Health Organization defines a zoonosis as any infection naturally transmissible from vertebrate animals to humans. COVID-19 caused by SARS-CoV-2 most likely originated in bats and transmitted to humans through a possible intermediate host, however, no animal reservoir has yet been found. Phylogenetic analysis of the &#946--coronavirus genera indicated that SARS-CoV-2 is similar to some viruses identified in bats in a group described as SARS/SARS-like CoV. Members of the virus species SARSrelated coronavirus that includes both SARS-CoV and SARS-CoV-2 as well as multiple genetically highly diversified bat-associated strains can infect different hosts belonging to four different mammalian orders, including bats, carnivores, pangolins and primates. In the tropics, direct contact between humans and bats potentially facilitating human infection is more frequent than in temperate climates. Human-to-animal transmission events during the COVID-19 pandemic have been documented in several countries. Case reports on cats Felis catus) living in the same household with COVID-19 patients, revealed that these animals can be infected with SARSCoV-2, showing either no or mild respiratory illness. Case report on two separate SARS-CoV-2-infected dogs (Canis lupus familiaris), whose owners were COVID-19 patients. Animal experimental infections can demonstrate the susceptibility of different animal species to SARS-CoV-2. A new structure-based approach has identified of potential intermediate hosts of SARS-CoV-2 by modeling the binding affinity between the SARS-CoV-2 Spike receptor-binding domain and the ACE2 protein of host animals. We conclusion that SARS-CoV-2 is a zoonotic disease.

Keywords: COVID-19- SARS-CoV-2- zoonotic diseases- zoonosis

Topic: Covid 19 in Emergency