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The Effect Of Honey In Liver Histopatology View On Mice (Mus musculus) Induced By Monosodium Glutamate (MSG) Study Program of Veterinary Medicine, Faculty of Medicine, Hasanuddin University, Jl. Perintis Kemerdekaan Km.10, Makassar, 90245, Indonesia Abstract Monosodium glutamate (MSG) is a commonly used flavoring agent, but excessive consumption of MSG can damage the liver so the liver requires exogenous antioxidants such as honey. This study aims to determine the effect of honey on histopathology images of liver mice after MSG administration. Research method with descriptive experimental. This study was conducted on 24 male mice divided into 4 groups. The control group, P1, P2, P3 were given an oral MSG of 4 mg / g BB. After 60 min, P2 and P3 were given peroral honey with a concentration of 5% at P2 and a concentration of 6% on P3 for 14 consecutive days. On the 15th day all of the dinecrops and liver mice were taken for preparing preparations using the method of embedding blocking with paraffin and hematoxylin eosin (HE) staining and analyzed descriptively qualitatively. The results showed that the treatment group 1 (KP 1) given MSG alone suffered more severe damage than the treatment groups 2 and 3 were also given honey 5% and 6%. Hepatocyte cell damage in all groups was fat degeneration, hydrophic degenration and necrosis. Histopathologic picture in treatment group 1 (KP 1) ie one field of view found more than 75% degeneration and necrosis on the observed part (severe damage). In the treatment group 2 (KP 2), one field of vision was found to be 21-50% degeneration and necrosis in the observed area. In the treatment group 3 (KP 3), one field of vision was found to be 21-50% degeneration and necrosis in the observed area. 5% and 6% concentration of honey concentrations can inhibit the liver damage of mice induced MSG mice. Keywords: Histopathology, honey, liver, mice, monosodium glutamate. Topic: Animal Laboratories |
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