Effect of Garcinia atroviridis and Kunci Pepet Extracts on the Recovery Time of Fatigue in Obese Rats
Min Rahminiwati (a), Panji Andhika Maharta (a), Pudji Achmadi (b), Sidik Muhamad Leluala (a), Aryani Sismin Satyaningtijas (b)

a).Divison of Pharmacology and Toxicology, Departement of Anatomy, Physiology and Pharmacology, Fakulty of veterinary Medicine IPB University (Bogor Agricultural university), Bogor Indondesia
b).Divison of Physiology , Departement of Anatomy, Physiology and Pharmacology, Fakulty of veterinary Medicine IPB University (Bogor Agricultural university), Bogor Indondesia


Abstract

The study was conducted to determine the effect of combined Garcinia atroviridis and Kunci Pepet (Kaempferia rotunda) on the stamina of obese rats (Rattus norvegicus) induced by a high fat diet. The amount 20 of obese Male Spragua dawley Rats were given combined extract of Garcinia and Kaempeferia dose 32 mg/200 g b.w. (DI), 96 mg/200 g b.w. (DII) and 288 mg/200g b.w. (DIII) respectively and aquadest as negative control. Forced swimming test was done to determine stamina by determining the duration of rat swimming time and blood lactate level. Blood lactate level was measured by Roche Accutrend Plus Meter Kit four times before and after the first forced swimming test (FST) and after getting rest immediately prior to and after the second FST. Combined Garcinia and Kunci Pepet was administered once a day for 30 consecutive days prior to and once a day after the first FST. The obtained data were analyzed statistically by one-way Analysis of Variance (ANOVA) method followed by the Duncan test. The results showed that the combined Garcinia atroviridis and Kunci pepet at a dose of 288 mg/200 g b.w. increase the duration of swimming time and blood lactate level in the first FST, as well as accelerate a decrease in blood lactate level after resting time. Booster stamina by readministration of combined Garcinia and Kunci Pepet before second FST to this group leads to the duration of second FST and blood lactate level insignificantly different from those of control. Combined Garcinia atroviridis and Kunci Pepet was capable to increase stamina in a continues period of activity but not in repeated activity separated by resting time. It was concluded that the combined Garcinia-kunci pepet increases stamina and accelerates the recovery of fatigue but does not boost the stamina in the presence of fatigue and fasting.

Keywords: Kunci Pepet, Garcinia atroviridis, stamina, blood lactate

Topic: Veterinary Anatomy, Physiology, Pharmacology

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