Obesity and ET-A Receptors expression on rat kidneys
M M Syuaib(1,2*) U A Miskad (1) H Cangara (1) I Idris (3) R Masadah(1) A Zainuddin(4) H Dahlan(1) and T Fujimura (5)

(1)Department of Pathology Anatomi, Faculty of Medicine, University of Hasanuddin, Makassar, Indonesia
(2)Department of Physiology, Faculty of Medicine and Health, Alauddin State Islamic University, Makassar, Indonesia
(3)Department of Physiology, Faculty of Medicine, University of Hasanuddin, Makassar, Indonesia
(4)Department of Public Health, Faculty of Medicine, University of Hasanuddin, Makassar, Indonesia
(5)Department of Dermatology, Kitasato University School of Medicine, Sagamihara, Kanagawa, Japan

Abstract

Endothelin system including Receptor Endothelin A (ET-A) is reported to play an important role in various diseases including obesity related chronic kidney disease (CKD). Several Journals have been studied about ET-A but assessment ET-A expression on tissue is less reported. ET-A predominate in vascular smooth muscle, their binding with ET-1 mediating many of the pathophysiological actions including vasoconstriction, reduction in renal blood flow and glomerulofiltration rate. We studied the differences of ET-A expressions in the various parts of cortex kidneys between case and control groups. The rats were divided into two groups based on the index Rohrer (IR). The case group (IR>30 gr/cm) was given a high-fat diet and the control (IR< 30 gr/cm) was assigned a standard diet. ET-A expressions was seen by Immunohistochemistry (IHC) from the paraffin-blocked kidneys. Result: In Cortex of Right Kidney, receptor ET-A of case group were more expressed than control group on various structures including glomerulus, distal tubule, artery, vena, and mesangial cell with p <0.05 but no differences were found between two group on proximal tubule structures.

Keywords: Endothelin-A, obesity

Topic: Veterinary Anatomy, Physiology, Pharmacology