Hepatoprotector Activity of Bligu Fruit Seed Extract (Benincasa hispida (thunb) cogn.) And Ants Plants Infusion (Myrmecodia pendans) in Rats (Rattus norvegicus) Induced by Paracetamol
Khaerani (a*), Hurria (b), Faridha Yenny Nonci (a), Nurshalati Tahar (a), Munifah Wahyuddin (a), Asrul Ismail (a), Fathana Arif (a), Nur Amirah Reski (a)

(a) Departement of Pharmacy, Medical and Health Sains Faculty, Universitas Islam Negeri Alauddin Makassar, Jalan Yasin Limpo 36 Gowa, South Sulawesi 90221, Indonesia
*khaerani.mukhtar[at]uin-alauddin.ac.id
(b) Department of Pharmacy, Faculty of Health Agriculture and Marine Science, Universitas Muhammadiyah Palopo, Jalan Jenderal Sudirman Km. 3 Kota Palopo, South Sulawesi 91921, Indonesia


Abstract

Hepatoprotectors from plants are preferred as alternative therapy because they are easier to obtain and safer. This study aims to determine the hepatoprotector activity of Bligu seeds extract (Benincasa hispida (Thunb) Cogn.) and ant plant infusion (Myrmecodia pendans) in rats (Rattus novergicus) induced by paracetamol using SGPT enzyme levels parameters. Bligu seeds were extracted using methanol while the ant plant made infusion, then tested on 15 rats wich were randomly divided into 5 tratment groups, that are the negative control group, the positive control group, the 100 mg/kg BW, 200 mg/kg BW and 400 mg/kg BW extract. And For Infusion, 100 g/kg BW, 200 g/kg BW and 300 g/kg BW. All groups induced using paracetamol 2,5 g/kgBW and given therapy for 7 days. SGPT levels were measured on the first day before treatment. After treatment continued with the induction of paracetamol wich waas given along follow up therapy. The results proved that the methanol extract of the seeds of Bligu (Benincasa hispida (Thunb) Cogn.) and the infusion of ant plant (Myrmecodia pendans) had a significance value > 0,05, which means that they have hepatoprotector activity where the extract dose is 400 mg/Kg BW for the Beligu seed extract and the dose 100 g/KgBW ant plant infusion were not signicantly different from the increase in SGPT levels on the effect of Curcuma suspension.

Keywords: Bligu Seed- Ant Plant- Hepatoprotector

Topic: Veterinary Anatomy, Physiology, Pharmacology

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