Clinical Study Phase I of Antidiabetic Herbal Formulation: Assessment of Liver and Kidney Function
Andi Suhendi (a), Muhtadi (a*), Fahrun Nur Rasyid (b), EM. Sutrisna (c)

a) Faculty of Pharmacy, Universitas Muhammadiyah Surakarta
Jl. A. Yani Pabelan Kartasura Surakarta 57102 Indonesia
*Email : muhtadi[at]ums.ac.id
b) Faculty of Health Sciences, Universitas Muhammadiyah Surakarta
Jl. A. Yani Pabelan Kartasura Surakarta 57102 Indonesia
c) Faculty of Medicine, Universitas Muhammadiyah Surakarta
Jl. A. Yani Pabelan Kartasura Surakarta 57102 Indonesia

Abstract

Previous research of groups stated that combination of snakehead fish (Channa striata) and Bitter Melon (Momordica charantia) had the potential to develop as antihyperglycemic in the therapy of diabetes mellitus. In order to evaluate safety aspect with parameters liver and kidney function in community, this research was conducted in healthy respondents. Design of the research is quasi-experimental with pre and post-test design. Determination of fasting blood glucose levels, liver and kidney functions was performed at Private Hospital in Boyolali, Central Java. Sixty healthy volunteers were divided into two groups, namely the treatment groups and the control groups (placebo). Fasting blood sugar levels, liver and kidney function, before and after treatment were statistically analysed using paired t-test. The results showed no significant differences were obtained in the examination of blood sugar, liver and kidney function on healthy volunteers before and after treatment on days 0 and 30 (p> 0.05). This study concluded that the combination formula of snakehead fish powder and bitter melon extract did not showed toxicity in liver and kidney function.

Keywords: Clinical study phase I, snakehead fish powder, bitter melon extract, liver function, kidney function

Topic: Health, Medical, Pharmacy and Technology