I am so interested with your presentation Dr. Heni. And I want
to ask something about nanogel.
Based on the presentation, it was not explained how the
characteristics of the nanogels were produced. The
characteristics influence the effect of the drug. what
characteristics are used?
We have tested the characteristics of the preparation in the second year of the study,
namely the spreadability, protective power, viscosity and stability test of the
preparation, while in this third year the researchers focused on testing the
effectiveness of nanogels in labor.
although characteristic tests have been carried out in the previous year, it is
recommended that the characteristics of the best formula of nanoemulgel be
showed. How about nano characteristics? what are the responses? is there any
entrapment efficiency evaluation?
The nano gel formulation was initiated
by making nano emulsion by adding the extract to some
an emulsion ingredient, namely mixing the extract into olive oil, sorbitol, and tween
80. The mangrove leaf extract nano emulsion was carried out by preparing the water
phase and oil phase. The oil phase is carried out by mixing the mangrove leaf extract
to olive oil and then added with sorbitol. Water phase is carried out by dissolving
methyl paraben and propyl paraben in hot aquadest over the waterbath and waited
until it dissolves completely. After it dissolves completely, then cooled and after cold
then added tween 80. Making nano emulsion is done by adding the oil phase to the
water phase gradually a little then stirred and homogenized using a magnetic steerer
with speed 200-300 rpm for 2x24 hours, then measured the particle size of the
preparation. Test Particle size was carried out at the University^s Nano Preparation
Development Laboratory Islam Indonesia Jogjakarta and produced nano size emulsion
of mangrove leaf extract equal to 22.1 nm.
